We have measured the electron-loss cross section for collisions between protons and highly excited hydrogen atoms having principal quantum numbers in the nominal n band 44%n% 50. The cm. collision energy range was 0.4 eV^ pp^ 61 eV. Theoretical ionization-cross-section results are compared with the data and are then used to unfold from the data the approximate electron-transfer cross section. Classical scaling calculations are found to be in reasonable agreement with the unfolded data while quantal predictions are not.The comparison of experiment and theory for H*-H(n) collisions leading to electron loss, the sum of electron transfer and ionization, has been limited to the one restricted case of principal quantum number n = l. 1 Although theory exists, the n dependence of the electron-loss cross section has never been measured in any collision energy range, either in this most fundamental ionatom system or in any other.The electron-transfer and ionization cross sections for low-energy (eV energy range) H + -H(high n) collisions are among those required for evaluation of the important role that electron-capture and -loss collisions involving excited states may have in affecting the transport properties of plasmas. 2 Astrophysically these collisions are believed to be important in the ionized-hydrogen (H II) regions in interstellar space. 3 It is the purpose of this Letter to report results of the first experimental study of H + -H(high n) collisions. The merged-beam electron-loss cross-section data cover the center-of-mass collision-energy range 0.4 eV< W^ 61 eV; the H(high n) target atoms had quantum numbers n in the nominal n band 44 % n % 50.The transition from "low"-to "high"-energy behavior of electron-transfer and ionization cross sections in ion-atom collisions occurs when the velocity v r of relative motion of the nuclei is comparable with the orbital velocity v" of the electron taking part in the collision. For H + -H(n) collisions, v r~v n when W^ 1.3x 10 4 n~2 eV. For n = l, this occurs at W^ 13 keV; forn = 47, at W ^6 eV. The cross-section data reported in this Letter cover both the low-and high-energy regions.The measurements were performed with a new, single-ion-source, merged-beam apparatus incorporating significant technological advances. The method is based on that introduced by Belyaev, Brezhnev, and Erastov. 4 Part of the apparatus is shown in Fig. 1. A pure H + beam with energy E B near 11 keV and energy spread measured to be % ± 20 eV around E B was generated with an rf ion source, accelerator, and mass analyzer system not shown in Fig.