Merging anterior–posterior and dorsal–ventral markers to trace neuronal lineages in the mouse brainstem

Abstract

jected after the onset of neural development, to assess the role Sip1 during cranial neural crest development. With this approach we can determine whether Sip1 functions similarly in cancer cells and neural crest EMT and if it has any additional functions during embryonic development. Our results show that loss of Sip1 has no effect on cranial crest specification, but it prevents or delays migration of the crest out of the dorsal neural tube. Future studies will identify the mechanism by which Sip1 regulates the onset of migration in these cells.Program/Abstract #455 Interaction between Cdx transcription factors and the Retinoic Acid pathway in patterning the posterior neural plate