2000
DOI: 10.1016/s0048-9697(00)00592-1
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Mercury species in the liver of ringed seals

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Cited by 87 publications
(76 citation statements)
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References 37 publications
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“…Conversely, selenium (Se) is recognized as an essential micronutrient for animals, active in the activities of enzymes. It has been reported that the liver of aquatic organisms may act as an organ for demethylation and/or sequestration of both organic and inorganic forms of mercury (Wagemann et al 2000), and that selenium is involved in both of these mechanisms (Ikemoto et al 2004). Literature reports that selenium presented in selenoproteins is involved in both demethylation and immobilization of mercury in aquatic organisms, especially in mammals, suggesting mercury selenide (HgSe) formation (Nigro and Leonzio 1996).…”
mentioning
confidence: 99%
“…Conversely, selenium (Se) is recognized as an essential micronutrient for animals, active in the activities of enzymes. It has been reported that the liver of aquatic organisms may act as an organ for demethylation and/or sequestration of both organic and inorganic forms of mercury (Wagemann et al 2000), and that selenium is involved in both of these mechanisms (Ikemoto et al 2004). Literature reports that selenium presented in selenoproteins is involved in both demethylation and immobilization of mercury in aquatic organisms, especially in mammals, suggesting mercury selenide (HgSe) formation (Nigro and Leonzio 1996).…”
mentioning
confidence: 99%
“…After centrifugating at 3500 rpm for 20 min, 3 ml toluene of the supernatant was transferred into a 10 ml centrifuge glass tube. 1 ml 10 mM Na 2 S 2 O 3 for back extraction was added 19 and then shaken for 1 h. After centrifugation for 20 min at 3500 rpm, 0.6 ml Na 2 S 2 O 3 phase was transferred into a 2 ml PE micro-centrifuge tube. Finally, the water phase was centrifuged at 12 000 rpm for 30 min, and stored in a refrigerator before injecting directly into the HPLC.…”
Section: Sample Extractionmentioning
confidence: 99%
“…Somente os estudos a nível celular vêm indicando que o selênio pode interagir com os elementos traço, mesmo em baixas doses, porém a sua forma química e o seu estado de oxidação são importantes e cruciais (Feroci et al 1997). Alguns estudos que mostraram a interação, função protetora, do selênio com o mercúrio: em algas, camarões, caranguejos, ostras, peixes (Eisler 1985) e mamíferos (Dietz et al 2000, Wagemann et al 2000, Cardellicchio et al 2002, Chen et al 2002, Endo et al 2002. Esse efeito é devido à existência de uma interação entre o mercúrio e as selenoproteínas, que influi tanto no metabolismo quanto no efeito tóxico do metilmercúrio nos organismos marinhos (Schultz et al 1994), demetilando o metilmercúrio e formando os grânulos inertes de HgSe, que se depositam principalmente no fígado e rins dos mamíferos (Endo et al 2002).…”
Section: Deficiência E Efeito Protetorunclassified
“…Somente para o mercúrio (Hg) esta interação parece já estar um pouco esclarecida. Estudos realizados com mamíferos marinhos (Wagemann et al 1998(Wagemann et al , 2000 mostraram, através de um mecanismo hipotético, que o selênio através das selenoproteínas proporciona a demetilação do metilmercúrio (MeHg) por meio da formação de grânulos inertes de seleneto mercúrico (HgSe) no fí-gado desses organismos. A seguir serão apresentados alguns pontos relevantes a respeito deste elemento de grande importância fisiológica e ecotoxicológica.…”
Section: Introductionunclassified