Mercury's neurotoxicity is characterized by its disruption of selenium biochemistry

Ralston, Nicholas V.C.; Raymond, Laura J.

doi:10.1016/j.bbagen.2018.05.009

Cited by 140 publications

(77 citation statements)

References 140 publications

(139 reference statements)

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“…One area of interest is the relative concentration of selenium to mercury in fish samples because of the relationship between mercury and selenoenzymes ( Ralston and Raymond, 2018 ). It is well documented that selenium is an antagonist to Hg in a variety of species ( Khan and Wang, 2009 ).…”

Section: Discussionmentioning

confidence: 99%

High-density element concentrations in fish from subtidal to hadal zones of the Pacific Ocean

Welty

Sousa

Dunnivant

et al. 2018

Heliyon

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Anthropogenic use of high density, toxic elements results in marine pollution which is bio-accumulating throughout marine food webs. While there have been several studies in various locations analyzing such elements in fish, few have investigated patterns in these elements and their isotopes in terms of ocean depth, and none have studied the greatest depth zones. We used a flame atomic absorption spectrophotometer-hydride system and an inductively coupled plasma-mass spectrometer to determine concentrations of the high-density elements arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), lead (Pb), mercury (Hg), nickel (Ni), selenium (Se), plus the light-metal barium (Ba), in fish ranging from bathyal (1000 m in Monterey Bay) to upper hadal zones (6500–7626 m in the Kermadec and Mariana Trenches) in the Pacific Ocean. Five species of fish—including the Mariana Trench snailfish, the world's deepest known fish newly discovered—were analyzed for patterns in total element concentration, depth of occurrence, Se:Hg ratio, plus mercury isotopes in the deepest species. Co and As levels decreased with depth. In the Mariana Trench, Pb, Hg, Cd, and Cu were higher than in all other samples, and higher in those plus Ba than in the Kermadec Trench. The latter samples had far higher Ni and Cr levels than all others. Mercury relative isotope analysis showed no depth trends in the deepest species. Se:Hg showed a large molar excess of Se in bathyal flatfish species. These patterns indicate that exposures to pollutants differ greatly between habitats including trenches of similar depths.

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Section: Discussionmentioning

confidence: 99%

High-density element concentrations in fish from subtidal to hadal zones of the Pacific Ocean

Welty

Sousa

Dunnivant

et al. 2018

Heliyon

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“…Similarly to As, Hg, Cd, Ag and Pb, also the Se in the environment is a seeker of sulfur, while is antagonistic to Hg [35]. Selenium at very low doses (ca.…”

Section: Nomentioning

confidence: 99%

Mineral constituents of conserved white button mushrooms: similarities and differences

Pankavec¹,

Hańć²,

Barałkiewicz³

et al. 2019

Rocz Panstw Zakl Hig

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Background. Mushrooms are a food that is often considered as an important source of minerals and other nutrients for consumers. There is little data on the minerals in mushrooms processed culinary and on the impact of processing. Objective. The research was aimed at understanding the similarities and differences in the mineral composition (Hg, Li, Mg, Al, Co, Ni, Cu, As, Se, Rb, Sr, Ag, Cd, Cs, Sb, Tl, Pb, U, Ba, Cr, Zn, Mn and V) of white button mushrooms (Agaricus bisporus) processed in industrial conditions. Material and methods. Fungal materials came from six producers. The elements were determined by ICP-MS DRC and CV-AAS using validated methods and QA/QC protocol. The interdependencies of 18 elements and 10 batches of mushrooms examined were tested with the help of principal component analysis. Results. Some significant differences were found in the content and composition of minerals in marinated white button mushrooms depending on producer. Conserved white button mushrooms are poorer in major essential elements but also in toxic Hg, As, Ag, Cd, Sb, Tl or Pb which has been reported for unprocessed mushrooms. Conclusions. The relatively higher levels of Ag in some batches seem to be largely explained by the quality of the substrate used for mushrooms cultivation, while of Li, Rb, Cs, Cr, Al, U, V, As and Mn (in part also of Ba and Sr) largely by the quality of the marinade.

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“…The natural antagonists of Hg are selenium (Se) and sulfur (S), with Se being a specific antagonist for MeHg (Ralston and Raymond 2018 ). Neither Se and S were determined in this study, although they can play a role in the protection of a consumer from the excess Hg (and MeHg) contained in wild mushrooms, e.g., in mushrooms of some genera from the family Boletaceae rich in Se (Falandysz 2013 ; Kavčič et al 2019 ; Nasr et al 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Mercury in traditionally foraged species of fungi (macromycetes) from the karst area across Yunnan province in China

Falandysz

Mędyk

Saba

et al. 2020

Appl Microbiol Biotechnol

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The objective of this study is to better quantify the occurrence, intake, and potential risk from Hg in fungi traditionally foraged in SW China. The concentrations and intakes of Hg were measured from 42 species including a “hard” flesh type polypore fungi and a” soft” flesh type edible species that are used in traditional herbal medicine, collected during the period 2011–2017. Three profiles of forest topsoil from the Zhenyuan site in 2015 and Changning and Dulong sites in 2016 were also investigated. The concentrations of Hg in composite samples of polypore fungi were usually below 0.1 mg kg−1 dry weight (dw) but higher levels, 0.11 ± 0.01 and 0.24 ± 0.00 mg kg−1 dw, were noted in Ganoderma applanatum and Amauroderma niger respectively, both from the Nujiang site near the town of Lanping in NW Yunnan. Hg concentrations in Boletaceae species were usually well above 1.0 mg kg−1 dw and as high as 10 mg kg−1 dw. The quality of the mushrooms in this study in view of contamination with Hg showed a complex picture. The “worst case” estimations showed probable intake of Hg from 0.006 μg kg−1 body mass (bm) (“hard” type flesh) to 0.25 μg kg−1 bm (“soft” flesh) on a daily basis for capsulated products, from 17 to 83 μg kg−1 bm (“soft” flesh) in a meal (“hard” type flesh mushrooms are not cooked while used in traditional herbal medicine after processing), and from 0.042 to 1.7 and 120 to 580 μg kg−1 bm on a weekly basis, respectively. Graphical abstract Key points • Polypore species were slightly contaminated with Hg. • Hg maximal content in the polypore was < 0.25 mg kg−1dry weight. • Many species from Boletaceae family in Yunnan showed elevated Hg. • Locals who often eat Boletus may take Hg at a dose above the daily reference dose.

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Mercury's neurotoxicity is characterized by its disruption of selenium biochemistry

Cited by 140 publications

References 140 publications

High-density element concentrations in fish from subtidal to hadal zones of the Pacific Ocean

High-density element concentrations in fish from subtidal to hadal zones of the Pacific Ocean

Mineral constituents of conserved white button mushrooms: similarities and differences

Mercury in traditionally foraged species of fungi (macromycetes) from the karst area across Yunnan province in China

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