Mercury induced haematological and biochemical anomalies in Ophiocephalus (Channa) punctatus

Sastry, K.V.; Sharma, Kamana

doi:10.1016/0378-4274(80)90067-3

Cited by 34 publications

(23 citation statements)

References 10 publications

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“…On the other hand, in non-chicken model also (teleost fish), Sastry and Sharma (1980) reported that SOD activity decreased in acute exposure to HgCl 2 and increased in chronic exposure to HgCl 2 , however, there was elevation of both AST and ALT either in acute or chronic exposure to HgCl 2 . Thus, ALT activity in serum, could serve as a marker enzyme to evaluate functional status of liver as suggested by Sobutskii et al (2007).…”

Section: Discussionmentioning

confidence: 99%

Estimation of some heavy metals in polluted well water and mercury accumulation in broiler organs

Hussein

Abu-Zinadah

EL-Rabey

et al. 2013

Braz. arch. biol. technol.

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Section: Discussionmentioning

confidence: 99%

Estimation of some heavy metals in polluted well water and mercury accumulation in broiler organs

Hussein

Abu-Zinadah

EL-Rabey

et al. 2013

Braz. arch. biol. technol.

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“…Our results do not permit a clear explanation for this controversy but some results in the literature may help to explain it. Previous reports showed that the effects of Hg 2+ on enzyme activities may differ according to the enzyme affected (34,35) and even within the different organs in the same animal (36).…”

Section: Effects Of Hg 2+ On Cholinergic Activitymentioning

confidence: 99%

Effects of mercury on the arterial blood pressure of anesthetized rats

Rossoni

Amaral

Vassallo

et al. 1999

Braz J Med Biol Res

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The available data suggests that hypotension caused by Hg 2+ administration may be produced by a reduction of cardiac contractility or by cholinergic mechanisms. The hemodynamic effects of an intravenous injection of HgCl 2 (5 mg/kg) were studied in anesthetized rats (N = 12) by monitoring left and right ventricular (LV and RV) systolic and diastolic pressures for 120 min. After HgCl 2 administration the LV systolic pressure decreased only after 40 min (99 ± 3.3 to 85 ± 8.8 mmHg at 80 min). However, RV systolic pressure increased, initially slowly but faster after 30 min (25 ± 1.8 to 42 ± 1.6 mmHg at 80 min). Both right and left diastolic pressures increased after HgCl 2 treatment, suggesting the development of diastolic ventricular dysfunction. Since HgCl 2 could be increasing pulmonary vascular resistance, isolated lungs (N = 10) were perfused for 80 min with Krebs solution (continuous flow of 10 ml/min) containing or not 5 µM HgCl 2 . A continuous increase in pulmonary vascular resistance was observed, suggesting the direct effect of Hg 2+ on the pulmonary vessels (12 ± 0.4 to 29 ± 3.2 mmHg at 30 min). To examine the interactions of Hg 2+ and changes in cholinergic activity we analyzed the effects of acetylcholine (Ach) on mean arterial blood pressure (ABP) in anesthetized rats (N = 9) before and after Hg 2+ treatment (5 mg/kg). Using the same amount and route used to study the hemodynamic effects we also examined the effects of Hg 2+ administration on heart and plasma cholinesterase activity (N = 10). The in vivo hypotensive response to Ach (0.035 to 10.5 µg) was reduced after Hg 2+ treatment. Cholinesterase activity (µM h -1 mg protein -1 ) increased in heart and plasma (32 and 65%, respectively) after Hg 2+ treatment. In conclusion, the reduction in ABP produced by Hg 2+ is not dependent on a putative increase in cholinergic activity. HgCl 2 mainly affects cardiac function. The increased pulmonary vascular resistance and cardiac failure due to diastolic dysfunction of both ventricles are factors that might contribute to the reduction of cardiac output and the fall in arterial pressure. Correspondence

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“…According to Nussey et al (1995), the study of the hematological picture is frequently utilized for the detection of physiopathological changes in different stress conditions such as exposure to heavy metals. Changes in the hematological profile of the fish exposed to mercury have been observed in Hoplias malabaricus (Oliveira-Ribeiro et al, 2006), Tilapia mossambica (Menezes and Quasim, 1984), Oreochromis aureus (Allen, 1994), Acipenser baeri (Mikryakov and Lapirova, 1996), Ctenopharyngodon idella (Shakoori et al, 1994), Pleuronectes platessa (Fletcher and White, 1986), Channa punctatus (Juneja & Mahajan, 1983;Sastry and Sharma, 1980), Aphanius dispar (Hilmy et al, 1980). Tilapia (Oreochromis sp.)…”

Section: Introductionmentioning

confidence: 99%

Hematological parameters in Nile Tilápia, Oreochromis niloticus exposed to sub-letal concentrations of mercury

Ishikawa

Ranzani-Paiva

Lombardi

et al. 2007

Braz. arch. biol. technol.

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Mercury induced haematological and biochemical anomalies in Ophiocephalus (Channa) punctatus

Cited by 34 publications

References 10 publications

Estimation of some heavy metals in polluted well water and mercury accumulation in broiler organs

Estimation of some heavy metals in polluted well water and mercury accumulation in broiler organs

Effects of mercury on the arterial blood pressure of anesthetized rats

Hematological parameters in Nile Tilápia, Oreochromis niloticus exposed to sub-letal concentrations of mercury

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