Purpose The aim of this study is to assess the seasonal variation in major ion distribution patterns and identify the origin and geochemical behavior of some trace metals of streamwaters bathing the mineralized Lom Basin. Methods Eighty-one water samples were collected during the dry and wet seasons and analyzed for major ions using AAS and 12 trace metals (Fe, Mn, V, Cr, Co, Ni, Cu, Zn, As, Cd, Pb, Hg) by ICP-MS. Results All physicochemical parameters besides pH and Cl -varied narrowly between both seasons. No seasonal variability was observed for Cl -given its conservative nature, while NO 3 -levels decreased in the wet period due to the dilution effect. Similarly, SO 4 2-concentrations were low for both seasons reflecting the dissolution of low sulphide minerals associated with gold deposits. In contrast, the concentration of Ca 2? , Mg 2? , Na ? , K ? and HCO 3 -slightly increased during the wet season as they are flushed from the soil layers by rain. Water samples had very low concentrations (\ 1 lg/l) of V, Cr, Co, Cu, Zn, Cd, Pb and significant concentrations of Fe and Mn.Conclusions The seasonal regime of streamwater chemistry is controlled by groundwater supply of major cations and HCO 3 -from chemical weathering, leaching of ions from surface soil layers during precipitation and dilution of nitrate by surface runoff during the wet season. In this tropical basin, low acidity and trace metal loadings revealed lateritic weathering of sulphides, entrapment of trace metals in Fe and Mn oxides and leaching into deep groundwater. Although the streams have not been impacted, these findings may guide policymakers for water chemistry evaluation in Cameroon.