Mercury concentrations in human placenta, umbilical cord, cord blood and amniotic fluid and their relations with body parameters of newborns

Kozikowska, Iwona; Binkowski, Łukasz J.; Szczepańska, Katarzyna; Sławska, Helena; Miszczuk, Katarzyna; Śliwińska, Magdalena; Łaciak, T.; Stawarz, Robert

doi:10.1016/j.envpol.2013.07.030

Cited by 46 publications

(14 citation statements)

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“…Other investigators reported increased odds for high blood Cd among Saudi mothers with smaller crown-rump length deliveries (Al-Saleh et al, 2014), and higher cord blood Cd was associated with shorter BL among infants in a highly contaminated area of China, although there was no association for maternal blood Cd or for PD or BW (Zhang et al, 2004). Likewise, no associations were noted for GA or BL in a recent Polish study of maternal and cord blood Hg (Kozikowska et al, 2013). Whereas urine Cd was inversely associated with BW and urine Sn with HC among Japanese mothers, no associations were detected for BL or for levels of Sb, As, Be, Cu, Pb, Mo, Se, and Zn similar to ours (Shirai et al, 2010).…”

Section: Discussionmentioning

confidence: 87%

“…Even at term, adult mortality is associated with earlier delivery (Crump et al, 2011). Investigators have described associations between background exposures to toxic and essential elements in pregnant women and birth outcomes (Al-Saleh et al, 2014; Gundacker et al., 2010; Kippler et al, 2012a; Kippler et al, 2012b; Kozikowska et al, 2013; Lee et al, 2010; Lin et al, 2011; Menai et al, 2012; Shirai et al, 2010; Tian et al, 2009; van Wijngaarden et al, 2014; Zhang et al, 2004). However, there are few data to assess the impact of preconception exposures; measurements made during pregnancy are subject to within-woman variability concurrent to gestation-related physiologic adaptations (Selevan et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Birth outcomes and background exposures to select elements, the Longitudinal Investigation of Fertility and the Environment (LIFE)

Bloom

Louis

Sundaram

et al. 2015

Environmental Research

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Evidence suggests that trace exposures to select elements may increase the risk for adverse birth outcomes. To investigate further, we used multiple regression to assess associations between preconception parental exposures to Pb, Cd, and total Hg in blood, and 21 elements in urine, with n=235 singleton birth outcomes, adjusted for confounders and partner’s exposure. Earlier gestational age at delivery (GA) was associated with higher tertiles of urine maternal W (−1.22 days) and paternal U (−1.07 days), but GA was later for higher tertiles of maternal (+1.11 days) and paternal (+1.30 days) blood Hg. Additional analysis indicated shorter GA associated with higher paternal urine Ba, W, and U, and with higher maternal blood Pb for boys, but GA was longer in association with higher maternal urine Cr. Birth weight (BW) was lower for higher tertiles of paternal urine Cs (−237.85 g), U (−187.34 g), and Zn (−209.08 g), and for higher continuous Cr (P=0.021). In contrast, BW was higher for higher tertiles of paternal urine As (+194.71 g) and counterintuitively for maternal blood Cd (+178.52 g). Birth length (BL) was shorter for higher tertiles of urine maternal W (−1.22 cm) and paternal U (−1.10 cm). Yet, higher tertiles of maternal (+1.11 cm) and paternal (+1.30) blood Hg were associated with longer BL. Head circumference at delivery was lower for higher tertiles of paternal urine U (−0.83 cm), and for higher continuous Mo in boys (−0.57 cm). Overall, associations were most consistently indicated for GA and measures of birth size with urine W and U, and paternal exposures were more frequently associated than maternal. Though limited by several factors, ours is the largest multi-element investigation of prospective couple-level trace exposures and birth outcomes to date; the novel observations for W and U merit further investigation.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Birth outcomes and background exposures to select elements, the Longitudinal Investigation of Fertility and the Environment (LIFE)

Bloom

Louis

Sundaram

et al. 2015

Environmental Research

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“…In mature adults, at the deepest level, gametes are protected by membranous barriers such as the blood testis barrier (BTB) in the male [173], [174] and by a difficult to penetrate membranous barrier in the oocyte of mammalian females [175]. After impregnation the placental barrier helps to guard the developing prenate from damaging metals, viruses, and nanoparticles [176]- [181] and the DNA of the developing individual is encased inside a difficult to penetrate nuclear envelope that must first be disassembled and then reconstructed as two new envelopes are constructed in cell mitosis [182].…”

Section: From the Vantage Point Of Tnr Theory It Appears Asmentioning

confidence: 99%

From Superficial Damage to Invasion of the Nucleosome: Ranking of Morbidities by the Biosemiotic Depth Hypothesis

Oller¹,

Shaw²

2019

ijSciences

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At their most abstract level, according to a certain generalized paradigm in biosemiotic philosophy grounded in well-established mathematical proofs, valid communications from molecules upward must be formally isomorphic to the dynamic true narrative representations (TNRs) of natural language systems that vest those meaningful signs with their functional (pragmatic) content. TNRs, in DNA, RNA, proteins, and higher constructions, therefore, are requisite to health in the individual, in interactions with the larger environment, and with other organisms. In homo sapiens, the generalized biosemiotic paradigm proves that morbidities in general must always, in some manner, involve degradation of internal and external communications through TNRs in DNA, RNA, protein language, organelles, cells, tissues, and organ systems. The mathematically grounded paradigm shows that any given TNR can be superveniently degenerated, by very coarse or very fine degrees, to many distinct fictions, errors, lies, and nonsense strings out to the absolute limit of a complete erasure. The depth hypothesis asserts that if the timing and breadth of any degenerative disruption can be held equal, in fact or in principle, the depth of penetration of any disruptive factor into biosignaling representations must in theory be pathognomonic of severity in the supervened morbidities. From meiosis through conception to maturity, ceteris paribus, corruptions deeper in the developmental hierarchy must be more harmful in the morbidities they supervene. The depth hypothesis suggests a differentiation of autoimmune disorders as deeper than allergies, but less so than prion diseases, tumorigenesis, and metastatic cancers in that order. It suggests, therefore, a potentially useful generalized ranking of morbidities.

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“…Heavy metal pollution has always been a serious environmental concern across the world for decades, being widely distributed in air, water, food and soil. In particular, mercury is a toxic heavy metal, and it can cause permanent damage to the human body even at a very low concentration [ 1 – 2 ]. People are put on high alert to avoid the occurrence of shocking pollution events.…”

Section: Introductionmentioning

confidence: 99%

Ratiometric fluorescent test paper based on silicon nanocrystals and carbon dots for sensitive determination of mercuric ions

Guo

Liu

et al. 2018

R. Soc. open sci.

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Classical dye absorption-based pH test papers are widely used to measure the degree of acidity of media for quantification or semi-quantification by the observation of the naked eye on the variation of colour. However, it remains a challenging task to extend portable and cheap methods to a wide range of analytes for accurate quantification. Here, we report a dosage-sensitive test paper for the assay of mercury ions (Hg2+) with wide colour evolution. The ratiometric fluorescent probe was prepared by mixing blue-emission silicon nanocrystals (Si NCs) and red-emission carbon dots (r-CDs). The Si NCs serve as the reaction site and the r-CDs as the internal reference. Upon the addition of Hg2+, the blue fluorescence of the Si NCs was quenched, while the red fluorescence of the r-CDs remained constant, resulting in the consecutive fluorescence colour changes from blue to orange red. The probe demonstrates high selectivity and sensitivity of the visualization assay of Hg2+ with a detection limit of 7.63 nM. Moreover, we printed the ratiometric fluorescence probe result onto a piece of filter paper to prepare a test paper, which represents an on-site, sensitive, rapid and cost-effective method for the visual determination of Hg2+ by the naked eye.

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Mercury concentrations in human placenta, umbilical cord, cord blood and amniotic fluid and their relations with body parameters of newborns

Cited by 46 publications

References 44 publications

Birth outcomes and background exposures to select elements, the Longitudinal Investigation of Fertility and the Environment (LIFE)

Birth outcomes and background exposures to select elements, the Longitudinal Investigation of Fertility and the Environment (LIFE)

From Superficial Damage to Invasion of the Nucleosome: Ranking of Morbidities by the Biosemiotic Depth Hypothesis

Ratiometric fluorescent test paper based on silicon nanocrystals and carbon dots for sensitive determination of mercuric ions

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