Mercury is a toxic heavy metal released into the environment from both natural and anthropogenic sources. It is of great interest to consumers as to whether it can cause neurological effects at low dose levels. The effects of organic mercury exposure at high levels have been demonstrated in several large-scale poisonings, particularly those in Japan and Iraq in the 1950s, '60s and '70s. These epidemics showed that organic mercury, in sufficient concentrations, is a potent neurotoxin that is especially harmful to the developing nervous system. Since the most common form of human exposure to organic mercury is through fish consumption, several epidemiological studies have examined the relationship between maternal fish intake and health effects in humans, especially the fetus.Levels of mercury in fish vary depending on factors such as: trophic level in the food chain, size, and habitat location. For this reason, it is important to gather information on mercury levels in different types of fish in various parts of the world. Results of recent studies have caused the Food and Drug Administration (FDA) and the Environmental Protection Agency (EPA) to issue new advisories on the fish consumption Rosalee S. Rasmussen is associated with the Oregon State University Seafood Laboratory, 2001 Marine Drive, Room 253, Astoria, OR 97103.for pregnant women and young children. However, there is concern that other individuals will significantly reduce their fish consumption also, thereby decreasing the potential health benefits of seafood. This review is meant to promote understanding of current issues regarding mercury in seafood and provides a compilation of up to date information on the following topics: background information on mercury; large scale mercury poisonings; epidemiology studies and risk assessment; and studies on mercury in tuna in different geographical locations.