Mercury binding to proteins disclosed by ESI MS experiments: The case of three organomercurials

Geri, Andrea; Zineddu, Stefano; Massai, Lara; Ronga, Luisa; Lobinski, Ryszard; Gailer, Jürgen; Messori, Luigi

doi:10.1016/j.jinorgbio.2024.112479

Cited by 1 publication

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“…While the two most important binding proteins for Cd 2+ in plasma are α 2 macroglobulin and human serum albumin (HSA) [ 77 ], there is considerable evidence for an additional plasma protein, namely apo-transferrin and another eight plasma proteins for which there is some evidence for Cd-binding [ 78 ]. With regard to CH 3 Hg + , there is direct evidence for its binding to the Cys-34 of HSA [ 79 ], which is therefore also the binding site on rabbit serum albumin (RSA) at near-physiological conditions [ 80 ]. In contrast, there is little direct experimental evidence for the binding of Hg 2+ to Cys-34 in HSA [ 77 , 81 ].…”

Section: Advances In the Toxicological Chemistry Of Metal(loid)s In B...mentioning

confidence: 99%

Toward a Mechanism-Driven Integrated Framework to Link Human Exposure to Multiple Toxic Metal(loid) Species with Environmental Diseases

Gailer

2024

IJMS

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The ongoing anthropogenic pollution of the biosphere with As, Cd, Hg and Pb will inevitably result in an increased influx of their corresponding toxic metal(loid) species into the bloodstream of human populations, including children and pregnant women. To delineate whether the measurable concentrations of these inorganic pollutants in the bloodstream are tolerable or implicated in the onset of environmental diseases urgently requires new insight into their dynamic bioinorganic chemistry in the bloodstream–organ system. Owing to the human exposure to multiple toxic metal(loid) species, the mechanism of chronic toxicity of each of these needs to be integrated into a framework to better define the underlying exposure–disease relationship. Accordingly, this review highlights some recent advances into the bioinorganic chemistry of the Cd2+, Hg2+ and CH3Hg+ in blood plasma, red blood cells and target organs and provides a first glimpse of their emerging mechanisms of chronic toxicity. Although many important knowledge gaps remain, it is essential to design experiments with the intent of refining these mechanisms to eventually establish a framework that may allow us to causally link the cumulative exposure of human populations to multiple toxic metal(loid) species with environmental diseases of unknown etiology that do not appear to have a genetic origin. Thus, researchers from a variety of scientific disciplines need to contribute to this interdisciplinary effort to rationally address this public health threat which may require the implementation of stronger regulatory requirements to improve planetary and human health, which are fundamentally intertwined.

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Section: Advances In the Toxicological Chemistry Of Metal(loid)s In B...mentioning

confidence: 99%

Toward a Mechanism-Driven Integrated Framework to Link Human Exposure to Multiple Toxic Metal(loid) Species with Environmental Diseases

Gailer

2024

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

Mercury binding to proteins disclosed by ESI MS experiments: The case of three organomercurials

Cited by 1 publication

References 35 publications

Toward a Mechanism-Driven Integrated Framework to Link Human Exposure to Multiple Toxic Metal(loid) Species with Environmental Diseases

Toward a Mechanism-Driven Integrated Framework to Link Human Exposure to Multiple Toxic Metal(loid) Species with Environmental Diseases

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