Mercury and selenium concentrations in the internal organs of toothed whales and dolphins marketed for human consumption in Japan

Endo, Tokiko; Haraguchi, Koichi; Sakata, Masakatsu

doi:10.1016/s0048-9697(02)00137-7

Cited by 70 publications

(42 citation statements)

References 17 publications

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“…Where Tamoxifen decreased the levels of liver GSH through its strong affinity for the (-SH) group (binds exclusively to the -SH group of GSH). Previously, the present data showed that high MDA, PCC, and low GSH in the Tamoxifen group, indicating heavy oxidative damage and low antioxidant levels 31,66 .…”

Section: Discussionsupporting

confidence: 46%

Untitled

2016

IJPSR

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Aim: The present study has been undertaken to investigate the therapeutic effect of GSE (Grape seed extracts) against Tamoxifen (TAM), induced hepatotoxicity in rat. Methods: The rats were divided into four groups • Group 1: rats were injected intraperitoneally (i.p.) with saline for seven days.• Group 2: Rats were treated with TAM in a dose of 45 mg/kg b·w/day, i.p., for seven successive days.• Group 3: Rats were administrated orally GSE (100 mg/kg b·w/day) for three weeks. Group 4: rats were injected (i.p.) (45 mg/kg b·w/day) of Tamoxifen for seven days, then treated daily with a single dose of GSE (100 mg/kg b·w/day) for three weeks respectively. Results: GSE reduced necrosis in the TAM-treated rat. And significantly increased (p<0.05) the levels of MDA and PCC, while the level of GSH was significantly (P<0.05) decreased. Treatment with GSE significantly (P<0.05) reduced. Tamoxifen significantly decreased (P<0.05) the level of NO. GSE significantly increases (P<0.05, Table 2) NO level. Flowcytometric analysis in liver cells, significant increases in apoptotic cells treated by TAM and decreases in the group exposed to TAM and treated with GSE. Conclusion: This study suggests that GSE possesses anti-oxidant effects against TAM toxicity.

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Section: Discussionsupporting

confidence: 46%

Untitled

2016

IJPSR

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“…However, the major part of mercury accumulated in the internal organs especially in the liver, exist as inorganic mercury, suggesting that demethylation of methylmercury is possible (Kehrig et al [6], Holsbeek et al [7]). The literature has proposed that the liver of the aquatic animals may act as an organ for mercury demethylation and/or the sequestration of both organic and inorganic forms of this element from the body (Endo et al [8]). …”

Section: Introductionmentioning

confidence: 99%

Total mercury and methylmercury in fish from a tropical estuary

Baêta¹,

Kehrig²,

Malm³

et al. 2006

WIT Transactions on Biomedicine and Health, Vol 10

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Mercury content, as methylmercury, in aquatic biota varies greatly among species from the same location. Many parameters may affect its accumulation and concentration in fish tissues. The study assessed total mercury (T-Hg) and methylmercury (MeHg) in the muscle, liver and gonad of Micropogonias furnieri -carnivorous fish, Bagre spp. -omnivorous fish and Mugil lizailiophagous fish from a polluted eutrophic estuary in the Brazilian Southeast coast, Guanabara Bay. Fish were collected during the years 1990, 1999 and 2003. T-Hg was determined by CV-AAS with sodium borohydride as a reducing agent. MeHg was identified and quantified in the toluene layer by GC-ECD. In all cases, the liver appears to be the preferential organ for mercury accumulation. T-Hg in muscle was higher and more variable in carnivorous than in omnivorous and iliophagous fishes. Carnivorous and omnivorous fishes presented a similar percentage of MeHg (99% and 97%) in the muscle. Iliophagous fish, which is at the lower level of this food chain, presented the lowest % MeHg in the muscle and liver, 52% and 9% respectively. However, the percentage of MeHg to T-Hg was around 25% in the liver of carnivorous and omnivorous fishes. In all cases, the gonad presented the lowest T-Hg, and the ratio of MeHg to T-Hg was around 1. In the year 1999, the samples of carnivorous and iliophagous fishes presented the highest T-Hg in the muscle. In this year, the fish specimens of both species showed sexual maturity and the highest total length. The sex of the specimens did not show any influence in the accumulation of mercury by the fish. The total length of the fish specimens presented a significant relationship with T-Hg in the muscle. The different feeding habits of the studied species are important for the accumulation of mercury and methylmercury by the organisms. Mercury, as methylmercury, is biomagnified through this food chain.

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“…Low elimination rates lead to increasing concentrations in web chains and storage in higher food-chain organisms (Pinho et al 2002). Dolphins are apex predators (André et al 1990, Endo et al 2002, MengHsien Chen et al 2002 and specimens stranded along the coast are an important source of chemical/ toxicological information in many geographical areas (Augier et al 1993, Holsbeek et al 1998, Cardellichio et al 2000, Frodello et al 2000, Zhou et al 2001, Cardellichio et al 2002, Meng-Hsien Chen et al 2002. The high tolerance of Relación entre las concentraciones de mercurio total y orgánico en tejidos de delfines comunes (Delphinus delphis) y su longitud a lo largo de la costa portuguesa…”

Section: Introductionmentioning

confidence: 99%

Relationships between total and organic mercury concentrations in tissues and length of common dolphins (Delphinus delphis) from the Portuguese coast

Cecilio¹

2006

CiencMar

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Mercury and selenium concentrations in the internal organs of toothed whales and dolphins marketed for human consumption in Japan

Cited by 70 publications

References 17 publications

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Untitled

Total mercury and methylmercury in fish from a tropical estuary

Relationships between total and organic mercury concentrations in tissues and length of common dolphins (Delphinus delphis) from the Portuguese coast

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