Mercury and neuromotor function among children in a rural town in Chile

Ohlander, Johan; Huber, Stella Maria; Schomaker, Michael; Heumann, Christian; Schierl, Rudolf; Michalke, Bernhard; Jenni, Oskar G.; Caflisch, Jon; Muñoz, Daniel Moraga; Ehrenstein, Ondine S. von; Radon, Katja

doi:10.1080/10773525.2015.1125585

Cited by 7 publications

(4 citation statements)

References 25 publications

(32 reference statements)

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“…Children are also at risk of exposure to toxic levels of Hg due to participation in amalgam burning or by being in the proximity of the amalgam burning sites. Some of these children have been shown to exhibit long-term neurological deficits (Ohlander et al 2016), suggesting that they have been exposed to toxic levels of Hg.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms involved in the transport of mercuric ions in target tissues

2016

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Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are taken up by and accumulate in numerous organs, including brain, intestine, kidney, liver, and placenta. In order to understand the toxicological effects of exposure to mercury, a thorough understanding of the mechanisms that facilitate entry of mercuric ions into target cells must first be obtained. A number of mechanisms for the transport of mercuric ions into target cells and organs have been proposed in recent years. However, the ability of these mechanisms to transport mercuric ions and the regulatory features of these carriers have not been characterized completely. The purpose of this review is to summarize the current findings related to the mechanisms that may be involved in the transport of inorganic and organic forms of mercury in target tissues and organs. This review will describe mechanisms known to be involved in the transport of mercury and will also propose additional mechanisms that may potentially be involved in the transport of mercuric ions into target cells.

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Section: Introductionmentioning

confidence: 99%

Mechanisms involved in the transport of mercuric ions in target tissues

2016

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“…The importance of using these biomarkers is due to the fact that they are considered highly accurate for measuring exposure to heavy metals (Park and Zheng, 2012). Hair and blood are often used as the best markers to measure neurotoxic and/or neurofunctional impact in populations exposed to these metals (Marques et al, 2013;Ohlander et al, 2016).…”

Section: Sampling For Exposure Biomarkersmentioning

confidence: 99%

Neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the Mojana region, Colombia

Ossa

Ramírez-Giraldo

Arroyo-Alvis

et al. 2023

Environmental Research

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“…In the 1960s, Pb was emerging as a major public health problem that might cause permanent brain damage [ 15 ]. Furthermore, several studies have reported that heavy metals can transfer across the placenta to the fetus, and may cross the blood–brain barrier (BBB) to directly affect the central nervous system, which may subsequently contribute to adverse neurodevelopmental outcomes involving cognition and sensorimotor functions [ 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Endocrine-Disrupting Chemicals and Subsequent Brain Structure Changes Revealed by Voxel-Based Morphometry and Generalized Q-Sampling MRI

Shen

Weng

Tsai

et al. 2021

IJERPH

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Previous studies have indicated that prenatal exposure to endocrine-disrupting chemicals (EDCs) can cause adverse neuropsychiatric disorders in children and adolescents. This study aimed to determine the association between the concentrations of prenatal EDCs and brain structure changes in teenagers by using MRI. We recruited 49 mother–child pairs during the third trimester of pregnancy, and collected and examined the concentration of EDCs—including phthalate esters, perfluorochemicals (PFCs), and heavy metals (lead, arsenic, cadmium, and mercury)—in maternal urine and/or serum. MRI voxel-based morphometry (VBM) and generalized q-sampling imaging (GQI) mapping—including generalized fractional anisotropy (GFA), normalized quantitative anisotropy (NQA), and the isotropic value of the orientation distribution function (ISO)—were obtained in teenagers 13–16 years of age in order to find the association between maternal EDC concentrations and possible brain structure alterations in the teenagers’ brains. We found that there are several specific vulnerable brain areas/structures associated with prenatal exposure to EDCs, including decreased focal brain volume, primarily in the frontal lobe; high frontoparietal lobe, temporooccipital lobe and cerebellum; and white matter structural alterations, which showed a negative association with GFA/NQA and a positive association with ISO, primarily in the corpus callosum, external and internal capsules, corona radiata, superior fronto-occipital fasciculus, and superior longitudinal fasciculus. Prenatal exposure to EDCs may be associated with specific brain structure alterations in teenagers.

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Mercury and neuromotor function among children in a rural town in Chile

Abstract: Elemental Hg exposure in the household might have adverse long-term effects on children's pure motor skills.

Cited by 7 publications

References 25 publications

Mechanisms involved in the transport of mercuric ions in target tissues

Mechanisms involved in the transport of mercuric ions in target tissues

Neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the Mojana region, Colombia

Prenatal Exposure to Endocrine-Disrupting Chemicals and Subsequent Brain Structure Changes Revealed by Voxel-Based Morphometry and Generalized Q-Sampling MRI

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