Mercury and Atherosclerosis: Cell Biology, Pathophysiology, and Epidemiological Studies

Farkhondeh, Tahereh; Afshari, Reza; Samarghandian, Saeed

doi:10.1007/s12011-019-01899-w

Cited by 19 publications

(12 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidative stress is a major factor that contributes to cell dysfunction and is linked to various diseases, including dyslipidemia [27]. Hg exposure induces the overproduction of reactive oxygen species following cell damage and the oxidation of low-density lipoprotein cholesterol [28]. Thus, it is speculated that pathogenesis is linked to abnormal lipid metabolism, which can develop into dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Association between Dyslipidemia and Mercury Exposure in Adults

Kang

Shin

Kim

2021

IJERPH

View full text Add to dashboard Cite

Background—Dyslipidemia is one of the prominent risk factors for cardiovascular disease, which is the leading cause of death worldwide. Dyslipidemia has various causes, including metabolic capacity, genetic problems, physical inactivity, and dietary habits. This study aimed to determine the association between dyslipidemia and exposure to heavy metals in adults. Methods—Using data from the seventh Korean National Health and Nutrition Examination Survey (2016–2017), 5345 participants aged ≥20 years who were tested for heavy metal levels were analyzed in this study. Multiple logistic regression was conducted to assess the factors affecting the prevalence of dyslipidemia. Results—The risks of dyslipidemia among all and male participants with mercury (Hg) levels of ≥2.75 μg/L (corresponding to the Korean average level) were 1.273 and 1.699 times higher than in those with levels of <2.75 μg/L, respectively. The factors that significantly affected the dyslipidemia risk were age, household income, body mass index, and subjective health status in both males and females. Conclusions—In adult males, exposure to Hg at higher-than-average levels was positively associated with dyslipidemia. These results provide a basis for targeted prevention strategies for dyslipidemia using lifestyle guidelines for reducing Hg exposure and healthy behavioral interventions.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between Dyslipidemia and Mercury Exposure in Adults

Kang

Shin

Kim

2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Many works claimed that the mercury has no known physiological role in human metabolism and its high concentration is strongly related with hypertension, coronary heart disease, myocardial infarction, cardiac arrhythmias, carotid artery obstruction and cerebrovascular accident [58,59]. Moreover it represents a risk factor in the atherosclerosis progression [60]. Selenium, and magnesium also appear to play an important role in the development of cardiovascular disease, but in this case the effect appears to be reversed.…”

Section: Discussionmentioning

confidence: 99%

Random Forests Highlight the Combined Effect of Environmental Heavy Metals Exposure and Genetic Damages for Cardiovascular Diseases

et al. 2021

View full text Add to dashboard Cite

Heavy metals are a dangerous source of pollution due to their toxicity, permanence in the environment and chemical nature. It is well known that long-term exposure to heavy metals is related to several chronic degenerative diseases (cardiovascular diseases, neoplasms, neurodegenerative syndromes, etc.). In this work, we propose a machine learning framework to evaluate the severity of cardiovascular diseases (CVD) from Human scalp hair analysis (HSHA) tests and genetic analysis and identify a small group of these clinical features mostly associated with the CVD risk. Using a private dataset provided by the DD Clinic foundation in Caserta, Italy, we cross-validated the classification performance of a Random Forests model with 90 subjects affected by CVD. The proposed model reached an AUC of 0.78 ± 0.01 on a three class classification problem. The robustness of the predictions was assessed by comparison with different cross-validation schemes and two state-of-the-art classifiers, such as Artificial Neural Network and General Linear Model. Thus, is the first work that studies, through a machine learning approach, the tight link between CVD severity, heavy metal concentrations and SNPs. Then, the selected features appear highly correlated with the CVD phenotype, and they could represent targets for future CVD therapies.

show abstract

“…Mercury also has been reported to be a risk factor in atherosclerosis progression. Most recently, it was reported that mercury can induce atherosclerosis indirectly since it can increase total cholesterol, triglycerides, and LDL levels, and, meanwhile, decrease the HDL level [107]. Therefore, exposure to different chemicals or biological agents may have a direct or inflammatory effect by affecting some molecular mechanism of cardiovascular diseases.…”

Section: Environment Factors In Atherosclerosismentioning

confidence: 99%

The Contribution of Endothelial-Mesenchymal Transition to Atherosclerosis

Zhang

Ogbu

Musich

et al. 2021

IJTM

View full text Add to dashboard Cite

Atherosclerosis is a chronic progressive condition in which the wall of the artery develops abnormalities and causes thickening of the blood vessels. The development of atherosclerosis is a complex process characterized by vascular inflammation and the growth of atherosclerotic plaques that eventually lead to compromised blood flow. The endothelial to mesenchymal transition (EndMT) is a phenomenon whereby endothelial cells lose their endothelial properties and acquire a mesenchymal phenotype similar to myofibroblast and smooth muscle cells. This process is considered a key contributor to the development and, importantly, the progression of atherosclerosis. Thus, therapeutically targeting the EndMT will provide a broad strategy to attenuate the development of atherosclerosis. Here, we review our current knowledge of EndMT in atherosclerosis including several key pathways such as hypoxia, TGF-β signaling, inflammation, and environmental factors during the development of atherosclerosis. In addition, we discuss several transgenic mouse models for studying atherosclerosis. Taken together, rapidly accelerating knowledge and continued studies promise further progress in preventing this common chronic disease.

show abstract

Mercury and Atherosclerosis: Cell Biology, Pathophysiology, and Epidemiological Studies

Cited by 19 publications

References 68 publications

Association between Dyslipidemia and Mercury Exposure in Adults

Association between Dyslipidemia and Mercury Exposure in Adults

Random Forests Highlight the Combined Effect of Environmental Heavy Metals Exposure and Genetic Damages for Cardiovascular Diseases

The Contribution of Endothelial-Mesenchymal Transition to Atherosclerosis

Contact Info

Product

Resources

About