Mercury accumulation in the Squirrel monkey eye after mercury vapour exposure

Warfvinge, Karin; Bruun, Anitha

doi:10.1016/0300-483x(95)03257-g

Cited by 41 publications

(38 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data are in line with our previous electroretinogram results showing impairment in retina function of these patients in full field and multifocal ERG measurements [148]. They also agree with morphological and image studies showing the mercury deposits in primates in retina [164,165] and in the human visual cortex [152,[166][167][168].…”

Section: Mercury Vapor Intoxicationsupporting

confidence: 81%

The Visual (dis)Function in Neurological Diseases

Fern

Costa²

2013

J Neurol Neurophysiol

View full text Add to dashboard Cite

Section: Mercury Vapor Intoxicationsupporting

confidence: 81%

The Visual (dis)Function in Neurological Diseases

Fern

Costa²

2013

J Neurol Neurophysiol

View full text Add to dashboard Cite

“…In addition to essential nutrients and ions, the RPE may also deliver toxic compounds and metals such as lead, cadmium, and mercury to the photoreceptors. Indeed, following exposure to Hg 0 , mercuric ions have been detected in the RPE and photoreceptor cells (Warfvinge and Bruun, 1996). This accumulation can have significant detrimental effects on the RPE and the adjacent photoreceptors (Erie et al, 2005;Fox and Sillman, 1979;Tessier-Lavigne et al, 1985;Bruun, 1996,2000).…”

Section: Introductionmentioning

confidence: 99%

“…The visual system has been shown to be susceptible to the toxicological effects of mercuric ions. In vivo studies in laboratory animals have shown that vision loss can result after exposure to Hg 0 , CH 3 Hg + or Hg 2+, (ATSDR, 2003;Evans and Garman, 1980;Finocchio et al, 1980;Fox and Sillman, 1979;Shaw et al, 1980;Tessier-Lavigne et al, 1985;Warfvinge and Bruun, 1996). Indeed, one of the earliest signs of mercury poisoning is an impairment of scotopic (night) vision (Evans and Garman, 1980).…”

Section: Introductionmentioning

confidence: 99%

Transport of thiol-conjugates of inorganic mercury in human retinal pigment epithelial cells

Bridges¹,

Battle²,

Zalups³

2007

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

Inorganic mercury (Hg 2+ ) is a prevalent environmental contaminant to which exposure to can damage rod photoreceptor cells and compromise scotopic vision. The retinal pigment epithelium (RPE) likely plays a role in the ocular toxicity associated with Hg 2+ exposure in that it mediates transport of substances to the photoreceptor cells. In order for Hg 2+ to access photoreceptor cells, it must be first be taken up by the RPE, possibly by mechanisms involving transporters of essential nutrients. In other epithelia, Hg 2+ , when conjugated to cysteine (Cys) or homocysteine (Hcy), gains access to the intracellular compartment of the target cells via amino acid and organic anion transporters. Accordingly, the purpose of the current study was to test the hypothesis that Cys and Hcy S-conjugates of Hg 2+ utilize amino acid transporters to gain access into RPE cells. Time-and temperaturedependence, saturation kinetics, and substrate-specificity of the transport of Hg 2+ , was assessed in ARPE-19 cells exposed to the following S-conjugates of Hg 2+ : Cys (Cys-S-Hg-S-Cys), Hcy (Hcy- S-Hg-S-Hcy), N-acetylcysteine (NAC-S-Hg-S-NAC) or glutathione (GSH-S-Hg-S-GSH).We discovered that only Cys-S-Hg-S-Cys and Hcy-S-Hg-S-Hcy were taken up by these cells. This transport was Na + -dependent and was inhibited by neutral and cationic amino acids. RT-PCR analyses identified systems B 0,+ and ASC in ARPE-19 cells. Overall, our data suggest that Cys-SHg-S-Cys and Hcy-S-Hg-S-Hcy are taken up into ARPE-19 cells by Na-dependent amino acid transporters, possibly systems B 0,+ and ASC. These amino acid transporters may play a role in the retinal toxicity observed following exposure to mercury.

show abstract

“…A detailed topographic analysis showed Hg deposits in the central and midperipheral parts of the retina but not in the peripheral retina. 42,43 Furthermore, retinal damage has been found in methylmercury intoxication as a reduction of the density in amacrine and bipolar cells, and alterations of the horizontal cells by electrophysiological measurements. 44,45 In humans exposed to Hg vapor, electrophysiological evidence for impairment of the peripheral retina has been found in full-field electroretinogram responses, and in the central retina by multifocal electroretinogram responses.…”

Section: Discussionmentioning

confidence: 99%