Mercuric acetate-mediated annulation of homopropargylic alcohols having thioether substituent. A general route for the synthesis of tetrasubstituted furans from propargylic dithioacetals

Asymmetric Propargylation of Ketones Using Allenylboronates Catalyzed by Chiral Biphenols

“…Homopropargyl alcohols are versatile building blocks for use in synthesis 1 possessing divergent options for synthetic transformations in comparison to the analogous homoallylic alcohol reagents. 2 However, few methods exist to prepare them in enantioenriched form.…”

Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles

“…In addition, one-pot “3 + 2” syntheses of furans featuring the generation of a key 2,3-dien-1-ol intermediate 2 - 537 , followed by its Hg(II)-mediated cyclization/elimination cascades to produce furan 2 - 538 , were reported by Tso and Tsay (Scheme ) and were later used by Luh and co-workers …”

A Metal-Free Tandem C–C/C–O Bond Formation Approach to Diversely Functionalized Tetrasubstituted Furans

“…Consequently, substantial consideration has been paid on the advance of effective methods to synthesize these heterocyclic compounds after the discovery of traditional condensation of 1,4-dicarbonyl compound reactions (Paal–Knorr synthesis) . During the past decade, numerous alternative approaches have been developed, and predominantly these reactions are either alkyne- or allene-assisted cyclizations. − Among the alkyne-based strategies to polysubstituted furans, cyclizations of enynones are particularly attractive (Scheme ). For instance, enynedione compounds were successfully utilized to prepare trisubstituted furans (path A) through the intramolecular cyclization .…”