Mercaptopropionylglycine: A Progress in Cystine Stone Therapy

Abstract

During a 4-year period 9 cases of severe recurrent cystine stones and cystinuria were treated with mercaptopropionylglycine. The oral long-term administration revealed the high effectiveness of the drug and resulted in no further stone formation. Mercaptopropionylglycine is free of side effects and more effective than D-penicillamine.

Cystinuria in Children

“…The side effects of MPG therapy reported up to a short time ago were minimal [16,18,[20][21][22], Also the data regarding experimental animals after prolonged high doses did not show important alterations in the principal organs [31].…”

Drug Therapy of Urinary Calculi and Prevention of Recurrence

“…First reports of effective reduction in cystine excretion by MPG medication came from KING (1969). Numerous other reports followed, initially in the japanese literature (SONODA et al 1970;KINOSHITA et al 1972;NISHIMURA et al 1972) and subsequently in America and Europe (THOMAS et al 1970;TACCINOLI et al 1973;REMIEEN et al 1975;TERHORST and STUHL-SATZ 1975;ZECHNER et al 1976;HAUTMANN et al 1977;MIANO et al 1979), all testifying to the excellent clinical efficacy of this agent.…”

Clinical Features and Management of Cystine Nephrolithiasis

“…This substance, with cystine, forms a cysteine-MPG disulphur complex, both in the plasma and in the urine, which is far more soluble than cystine. This drug, which is non toxic and has a higher oxide-reducing capacity than d-penicillamine, seems to be more efficient as a therapeutic agent (5,6,7,8,12,15,17). For preventive purposes in adults 1 g/day MPG (Thiola R) was given in 2 doses before meals, whilst for stone dissolution 1.5 g/day was given in 3 doses; in children the dosage was 30-40 mg/kg/day.…”