Menthone supplementation ameliorates systemic allergic inflammation in asthmatic mice via regulating Th2-skewed immune balance

Su, Yi-Hsuan; Lin, Jin‐Yuarn

doi:10.1016/j.phyplu.2022.100322

Cited by 6 publications

(4 citation statements)

References 45 publications

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“…The anti-inflammatory activity of M. × piperita on TNF-α is reported both in the ethanol extract [30] and in the EO [31]. Major compounds, menthol [32] and menthone [33], have been related as modulators of the inflammatory response. Although V. curassavica did not significantly decrease the concentration of TNF-α, according to the literature, the anti-inflammatory activity of EO comes from the joint action of α-Humulene and its isomers [34].…”

Section: Resultsmentioning

confidence: 99%

Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control

Cassola,

Ramírez,

Ribeiro

et al. 2023

Planta Med

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Seborrheic dermatitis is a chronic inflammatory disease caused by Malassezia yeast species that affects the regions of the body where the sebaceous glands are present. The combined use of different essential oils (EOs) can increase their spectrum of action. Thus, the present study aimed to evaluate the action of EOs alone and in combination with each other on M. furfur, in planktonic and biofilm form, and their anti-inflammatory and mutagenic potential, in addition to the effects on the viability of cells lines. Of the 40 evaluated EOs, 22 showed activity against M. furfur at 0.5 – 2.0 mg/mL concentrations. Among the most active species, a blend of essential oils (BEOs) composed of Cymbopogon martini (Roxb.) Will. Watson (MIC = 0.5 mg/mL) and Mentha × piperita L. (MIC = 1.0 mg/mL) was selected, which showed a synergistic effect against yeast when evaluated through the checkerboard assay. The fungicidal activity was maintained by the addition of anti-inflammatory oil from Varronia curassavica Jacq. to BEOs. The BEOs also showed activity in the inhibition of biofilm formation and in the eradication of the biofilm formed by M. furfur, being superior to the action of fluconazole. Furthermore, it did not show mutagenic potential and did not interfere with the cell viability of both evaluated cell lines (HaCaT and BMDMs). TNF-α levels were reduced only by C. martini; however, this property was maintained when evaluating BEOs. BEOs had no effect on IL-8 levels. Thus, the BEOs may be indicated for alternative treatments against seborrheic dermatitis.

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Section: Resultsmentioning

confidence: 99%

Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control

Cassola,

Ramírez,

Ribeiro

et al. 2023

Planta Med

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“…Pulegone is an economical and widely used flavoring agent, aromatherapeutic, and pharmaceutical [25,26]. In addition, it is a peppermint essential oil that has anti-inflammatory effects [27,28]. Therefore, the cultivation of island A. rugosa, which contains higher amounts of pulegone, is more effective than that of inland A. rugosa in terms of harvesting medicinal materials.…”

Section: Discussionmentioning

confidence: 99%

Comparative Morphology of Island and Inland Agastache rugosa and Their Gastroprotective Effects in EtOH/HCl-Induced Gastric Mucosal Gastritis

Song,

Nam,

Park

et al. 2023

Planta Med

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Agastache rugosa Kuntze (Lamiaceae; Labiatae), a medicinal and functional herb used to treat gastrointestinal diseases, grows well both on islands and inland areas in South Korea. Thus, we aimed to reveal the morphological and micromorphological differences between A. rugosa grown on island and inland areas and their pharmacological effects on gastritis in an animal model by combining morphological and mass spectrophotometric analyses. Morphological analysis showed that island A. rugosa had slightly smaller plants and leaves than inland plants; however, the density of all types of trichomes on the leaves, petioles, and stems of island A. rugosa was significantly higher than that of inland plants. The essential oil component analysis revealed that pulegone levels were substantially higher in island A. rugosa than in inland A. rugosa. Despite the differences between island and inland A. rugosa, treatment with both island and inland A. rugosa reduced gastric damages by more than 40% compared to the gastritis induction group. In addition, expression of inflammatory protein was reduced by about 30% by treatment of island and inland A. rugosa. The present study demonstrates quantitative differences in morphology and volatile components between island and inland plants; significant differences were not observed between the gastritis-inhibitory effects of island and inland A. rugosa, and the efficacy of island A. rugosa was found to be similar to that of A. rugosa grown in inland areas.

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“…[10,11] For this reason, this compound has received growing interest from medicinal chemists due to their wide range of biological activities. [10,12] This compound is of great importance in several areas, proving to be efficient for depressive disorders, antinflamimatory potential, DNA damage in sperm cells and type 1 allergic reaction. [12] It can also be conveniently prepared by oxidation of L-menthol, which is the major component of peppermint essential oil.…”

Section: Introductionmentioning

confidence: 99%

“…[10,12] This compound is of great importance in several areas, proving to be efficient for depressive disorders, antinflamimatory potential, DNA damage in sperm cells and type 1 allergic reaction. [12] It can also be conveniently prepared by oxidation of L-menthol, which is the major component of peppermint essential oil. For this reason, this compound has received growing interest from medicinal chemists due…”

Section: Introductionmentioning

confidence: 99%

Menthol Oxidation to Menthone: An Important Chemical Transformation

2023

General Chemistry

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Oxidation is a key transformation in chemistry being involved in a wide range of processes. In natural products, this reaction plays a critical role in the biosynthesis of several classes from different sources. In this context, the oxidation of menthol to menthone is an important reaction with a variety of applications in several fields, such as natural products, organic synthesis, and medicinal chemistry. Considering this, the present article aims to review different methodologies and oxidation reagents capable of performing this transformation, including the green chemistry process.

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Menthone supplementation ameliorates systemic allergic inflammation in asthmatic mice via regulating Th2-skewed immune balance

Cited by 6 publications

References 45 publications

Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control

Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control

Comparative Morphology of Island and Inland Agastache rugosa and Their Gastroprotective Effects in EtOH/HCl-Induced Gastric Mucosal Gastritis

Menthol Oxidation to Menthone: An Important Chemical Transformation

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