Mental Stress and Its Effects on Vascular Health

Sara, Jaskanwal D.; Toya, Takumi; Ahmad, Ali; Clark, Matthew M.; Gilliam, Wesley P; Lerman, Lliach O.; Lerman, Amir

doi:10.1016/j.mayocp.2022.02.004

Cited by 52 publications

(50 citation statements)

References 227 publications

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“…Consistently, withdrawal of the PNS activity contributes to physiological stress reactions (e.g. reduced heart rate variability) and adversely affects the immune system 19 .…”

Section: Stress Measurement In Human and Animal Studiesmentioning

confidence: 96%

“…Conversely, activation of the SNS-mediated release of norepinephrine tends to increase the secretion of those molecules. Thus, stressful conditions associated with sustained SNS activity or withdrawal of the PNS may elevate the levels of these proinflammatory proteins contributing to chronic inflammation 19 . There is also a bidirectional communication between the immune systems and stress neuroendocrine axes, as certain cytokines can trigger the activation of the HPA axis and the SNS.…”

Section: Pns Activation Leads To Release Of Neurotransmitter Acetylch...mentioning

confidence: 99%

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The multiple roles of life stress in metabolic disorders

2022

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The stress response is evolutionarily conserved across vertebrates to maintain homeostasis, but in excess can be damaging for body functions. We review the most recent research from basic sciences and epidemiology linking stress to the development and progression of metabolic disorders across the life course. Findings from rodents demonstrate that stress can affect features of metabolic dysfunction, such as insulin resistance, glucose and lipid homeostasis, as well as fundamental ageing processes such as cellular senescence and telomere length shortening. In human studies, stressors in the home, workplace and neighbourhood are associated with accelerated biological ageing and metabolic and immune alterations, both directly as well as indirectly via behavioural risks, including low physical activity, sleep disturbances, and alcohol abuse. The likelihood of developing clinical conditions, such as diabetes and fatty liver disease is increased in individuals with adverse childhood experiences or long-term stress at work or in private life -often as part of disease trajectories associated with other stress-related disorders, such as mental health problems, cardiovascular disease and increased susceptibility to infections. Among people with a metabolic disorder, stress may worsen disease prognosis. As favourable modifications in stressors are associated with reductions in incidence of metabolic disorders, the therapeutic value of targeting stress in personalised medicine merits further investigation.

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“…Consistently, withdrawal of the PNS activity contributes to physiological stress reactions (e.g. reduced heart rate variability) and adversely affects the immune system 19 .…”

Section: Stress Measurement In Human and Animal Studiesmentioning

confidence: 96%

Section: Pns Activation Leads To Release Of Neurotransmitter Acetylch...mentioning

confidence: 99%

The multiple roles of life stress in metabolic disorders

2022

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“…Prolonged psychological stress is now seen as an important risk factor for the entire vascular system. 1 However, there have been relatively few studies on the effects of psychological stress on the microcirculation. Psychological stress is associated with increased levels of norepinephrine in the circulation, which can cause microvascular vasoconstriction.…”

mentioning

confidence: 99%

Effect of Psychological Stress on Microcirculation Oscillations: Diagnostic Aspects

Gębicki¹,

Katarzyńska²,

Marcinek³

2023

VHRM

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“…Chronic psychosocial stress, as well as anxiety and depression, can exacerbate coronary artery atherosclerosis and transient endothelial dysfunction through excessive sympathetic nervous system activation 8,9 . Hyperresponsivity of the sympathetic nervous system, manifested by exaggerated heart rate and blood pressure responses to psychological stimuli, is considered an intrinsic characteristic in some individuals 8,9 . There is evidence that sympathetic nervous system hyperresponsivity accelerates the development of carotid atherosclerosis.…”

mentioning

confidence: 99%

Psychological factors and atherosclerotic cardiovascular disease development in women: A narrative review

Vlachopoulou¹,

Vassou²,

Panagiotakos³

2022

JAPT

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Cardiovascular disease (CVD) is the leading cause of mortality, with rising evidence of differences between women and men, worldwide. Data from the literature indicate the presence of gender-specific differences both in biological responses and in lifestyle behaviors to psychological stress. There is evidence suggesting that women experience higher levels of psychological problems, such as anxiety and depression. The connection between psychological factors and CVD can be explained by behavioral and biological risk factors, as well as underlying mechanisms, such as the sympathetic nervous system overactivity and the hypothalamic-pituitary-adrenal function impairment. Moreover, some psychosocial factors may place women at particular risk of CVDs. Given these hypotheses, the present review summarizes the existing knowledge about psychological factors and CVD connection in women, highlighting the sex differences.

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Mental Stress and Its Effects on Vascular Health

Cited by 52 publications

References 227 publications

The multiple roles of life stress in metabolic disorders

The multiple roles of life stress in metabolic disorders

Effect of Psychological Stress on Microcirculation Oscillations: Diagnostic Aspects

Psychological factors and atherosclerotic cardiovascular disease development in women: A narrative review

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