Mental stress affects the occurrence and development of psoriasis through neuroendocrine-immune regulation: a narrative review

Li, Fēi; Zhang, Yin-Lian; Chen, Xi; Zhang, Jingyu; Li, Fu; Chai, Bin; Chen, Hong-Xiang

doi:10.1097/jd9.0000000000000317

Cited by 2 publications

(3 citation statements)

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“…This study indicated FOS was the shared biomarkers between psoriasis and IBD, and further constructed a screening model with excellent diagnostic capabilities based on individual biomarkers. The discovery of the shared susceptibility genes, biomarkers, immune mechanisms, and the construction of the screening model may 1 provide a foundation for further exploration on the shared pathogenesis of psoriasis and IBD and the development of precise drug targets with dual effects 2 . prompt the occurrence of comorbidities for populations with the screening gene models, predict the direction of disease development, and provide a basis for personalized diagnosis and treatment plans for specific populations 3 .…”

Section: Discussionmentioning

confidence: 99%

“…We used “psoriasis”, “ulcerative colitis”, and “Crohn's disease” as the searching words in the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/), and selected eligible datasets according to the following criteria 1 : The species source of these datasets is human (Homo sapiens), 2 Samples for sequencing are tissues.…”

Section: Methodsmentioning

confidence: 99%

“…Psoriasis is a chronic autoimmune disorder with a complicated genetic background, 1,2 as the concordance rates in monozygotic and dizygotic twins were approximately 70% and 20%, respectively 3 . At the time when plasma cell like dendritic cells are activated by genetic and/or environmental factors, it will produce a large number of pro‐inflammatory cytokines, including tumor necrosis factor (TNF)‐α, interferon‐γ, interleukin (IL)‐17/22/23/1β, psoriasis occurs 4 …”

Section: Introductionmentioning

confidence: 99%

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Exploration of the biomarkers of comorbidity of psoriasis with inflammatory bowel disease and their association with immune infiltration

Ding,

Zheng,

2023

Skin Research and Technology

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BackgroundThere was evidence that significant bidirectional associations between psoriasis and inflammatory bowel diseases (IBDs), which influences management strategy of the patients, so the investigation on the mechanisms by which these two diseases co‐occur is important.MethodsThe Gene Expression Omnibus (GEO) database was used to download gene expression profiles of psoriasis and IBD. The differentially expressed genes (DEGs) between disease and health control groups for each data set were calculated, and Venn diagram was used to obtain for intersection. We performed Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis on the intersection, followed by developing a protein–protein interaction network and module construction, and identified hub genes by cytoHubba. Thereafter, least absolute shrinkage and selection operator algorithms was used to identify the co‐biomarkers of psoriasis and IBD from the top 50 hub genes. The biomarkers were used to construct a screening model, the discriminatory capacity of which was verified by receiver operating characteristic (ROC) curves. CIBERSORT algorithm was utilized to estimate the compositional patterns of immune cell infiltration in biomarkers of psoriasis and IBD. Spearman rank correlation analysis was used to further evaluate the correlation between the identified biomarkers and immune cells.ResultsA total of 271 shared DEGs were screened. The GO and KEGG enrichment analysis indicated that the shared DEGs were mainly enriched in response to lipopolysaccharide, secretory granule lumen, cytokine activity, and interleukin (IL)‐17 signaling pathway. Fifty genes such as IL1B, IL6, were identified as hub genes, based on which, FOS, IFI44, MMP9, MNDA, PTGS2, S100A9, and STAT1 were identified as biomarkers of psoriasis. CCL20, CD274, CTGF, CXCL1, CXCL10, CXCL2, CXCL9, FCGR3B, FOS, GBP1, GZMB, IFI27, IFI6, IL1RN, ISG15, ISG20, LCN2, LILRB2, MMP12, MMP7, S100A8, TLR8, and TNFSF13B were identified as biomarkers of IBD. FOS was the common biomarker of psoriasis and IBD. Screening models were validated in the validation data set (Psoriasis: area under the curve (AUC) = 1.000, IBD: AUC = 0.870). Immunocyte infiltration analysis showed the macrophages cells, mast cells resting, and T cells CD4 memory activated have the common characteristics in psoriasis and IBD.ConclusionsFOS may play a key role in the occurrence and development of psoriasis complicated with IBD and macrophages cells may be an entrance for treating this comorbidity.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%