Mental State of Inpatients With COVID-19: A Computational Psychiatry Approach

Sorokin, Mikhail Yu.; Kibitov, Andrey A.; Kasyanov, E. D.; Khobeysh, Maria A.; Zubova, E Yu

doi:10.3389/fpsyt.2022.801135

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…The severity of cognitive impairment, as a rule, correlates with the severity of COVID-19 [11,26], which is similar to the results of the present study.…”

Section: Resultssupporting

confidence: 91%

“…These rates significantly exceed the levels of depression, anxiety, and insomnia before the pandemic among both hospital patients and the general population. Studies also report that mental disorders tend to be more common among hospitalised patients with COVID-19 [11], and clinically significant cognitive decline is especially frequent among elderly people who have been infected with this virus [12].…”

Section: Introductionmentioning

confidence: 99%

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Association of Anxiety and Depression with Objective and Subjective Cognitive Decline in Outpatient Healthcare Consumers with COVID-19: А Cross-Sectional Study

Gomzyakova

Тумова

Kasyanov

et al. 2022

Consortium Psychiatricum

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BACKGROUND: In addition to the neurological complications affecting people infected with COVID-19, cognitive impairment symptoms and symptoms of anxiety and depression remain a frequent cause of complaints. The specificity of cognitive impairment in patients with COVID-19 is still poorly understood. AIM: An exploratory study of factors that may be associated with cognitive decline during the COVID-19 pandemic. METHODS: The cross-sectional multicentre observational study was conducted in a polyclinic unit in Saint Petersburg and in the regions of the North-Western Federal Region. During the study, socio-demographic parameters and information about the somatic condition of patients who applied for primary health care was collected. Emotional and cognitive state were investigated using the Hospital Anxiety and Depression Scale (HADS) and Montreal Cognitive Assessment (MoCA). Mathematical and statistical data processing was carried out using SPSS and RStudio statistical programs. RESULTS: The study included 515 participants, 60% (n=310) of which were women. The sample was divided into those who did (28.5%, n=147) and did not (71.4%, n=368) complain of cognitive decline. Patients with complaints of cognitive decline were significantly older, had lower levels of education and higher levels of depression and anxiety according to HADS (p 0.05). Patients with complaints of cognitive decline underwent the MoCA test (24.3%, n=125). The median MoCA test scores were within the normal range (Median=27, Q1=25, Q3=28), and cognitive decline (MoCA less than 26 points) was detected in 40% (n=50) of patients with complaints of cognitive decline. No significant correlations were found between the MoCA scores and the levels of anxiety and depression according to the HADS (p 0.05). Patients with mild severity of the COVID-19 course were more successful with MoCA subtests than patients with moderate and severe courses. CONCLUSION: We found no linear association between objective cognitive deficit and the affective state of respondents. Patients subjective complaints about cognitive dysfunction were mostly caused by their emotional state than an objective decrease of their cognitive functions. Therefore, in case of subjective complaints on cognitive decline, it is necessary to assess not only the cognitive but also the affective state of the patient. The severity of the COVID-19 course affects the functions of the cognitive sphere, including attention, regulatory functions and speech fluency. Mild and moderate severity of the COVID-19 correlates with clinically determined depression. The absence of this relationship with the severe course of the disease is probably explained by the significant somatic decompensation of patients.

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“…The severity of cognitive impairment, as a rule, correlates with the severity of COVID-19 [11,26], which is similar to the results of the present study.…”

Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Association of Anxiety and Depression with Objective and Subjective Cognitive Decline in Outpatient Healthcare Consumers with COVID-19: А Cross-Sectional Study

Gomzyakova

Тумова

Kasyanov

et al. 2022

Consortium Psychiatricum

Self Cite

View full text Add to dashboard Cite

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Mental Health and Psychological Well-Being of the Elderly During the COVID-19 Pandemic in Russia

Vasileva

Syunyakov

Sorokin

et al. 2023

Handbook on COVID-19 Pandemic and Older Persons

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Risk assessment of psychiatric complications in infectious diseases: CALCulation of prognostic indices on example of COVID-19

Sorokin,

Markin,

Trufanov

et al. 2024

Front. Psychiatry

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IntroductionFactors such as coronavirus neurotropism, which is associated with a massive increase in pro-inflammatory molecules and neuroglial reactivity, along with experiences of intensive therapy wards, fears of pandemic, and social restrictions, are pointed out to contribute to the occurrence of neuropsychiatric conditions.AimThe aim of this study is to evaluate the role of COVID-19 inflammation-related indices as potential markers predicting psychiatric complications in COVID-19.MethodsA total of 177 individuals were examined, with 117 patients from a temporary infectious disease ward hospitalized due to COVID-19 forming the experimental group and 60 patients from the outpatient department showing signs of acute respiratory viral infection comprising the validation group. The PLR index (platelet-to-lymphocyte ratio) and the CALC index (comorbidity + age + lymphocyte + C-reactive protein) were calculated. Present State Examination 10, Hospital Anxiety and Depression Scale, and Montreal Cognitive Assessment were used to assess psychopathology in the sample. Regression and Receiver operating characteristic (ROC) analysis, establishment of cutoff values for the COVID-19 prognosis indices, contingency tables, and comparison of means were used.ResultsThe presence of multiple concurrent groups of psychopathological symptoms in the experimental group was associated (R² = 0.28, F = 5.63, p < 0.001) with a decrease in the PLR index and a simultaneous increase in CALC. The Area Under Curve (AUC) for the cutoff value of PLR was 0.384 (unsatisfactory). For CALC, the cutoff value associated with an increased risk of more psychopathological domains was seven points (sensitivity = 79.0%, specificity = 69.4%, AUC = 0.719). Those with CALC > 7 were more likely to have disturbances in orientation (χ² = 13.6; p < 0.001), thinking (χ² = 7.07; p = 0.008), planning ability (χ² = 3.91; p = 0.048). In the validation group, an association (R²McF = 0.0775; p = 0.041) between CALC values exceeding seven points and the concurrent presence of pronounced anxiety, depression, and cognitive impairments was demonstrated (OR = 1.52; p = 0.038; AUC = 0.66).DiscussionIn patients with COVID-19, the CALC index may be used for the risk assessment of primary developed mental disturbances in the context of the underlying disease with a diagnostic threshold of seven points.

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Mental State of Inpatients With COVID-19: A Computational Psychiatry Approach

Cited by 3 publications

References 31 publications

Association of Anxiety and Depression with Objective and Subjective Cognitive Decline in Outpatient Healthcare Consumers with COVID-19: А Cross-Sectional Study

Association of Anxiety and Depression with Objective and Subjective Cognitive Decline in Outpatient Healthcare Consumers with COVID-19: А Cross-Sectional Study

Mental Health and Psychological Well-Being of the Elderly During the COVID-19 Pandemic in Russia

Risk assessment of psychiatric complications in infectious diseases: CALCulation of prognostic indices on example of COVID-19

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