Mental State Inferences Abilities Contribution to Verbal Irony Comprehension in Older Adults with Mild Cognitive Impairment

Gaudreau, Geneviève; Monetta, Laura; Macoir, Joël; Poulin, Stéphane; Laforce, Robert; Hudon, Carol

doi:10.1155/2015/685613

Cited by 20 publications

(23 citation statements)

References 44 publications

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“…Seventeen studies involving 513 (55.6% females) individuals with MCI and 693 (60.5% females) healthy controls were included (Table 1). 11–12,14,19–20,21 –32 Fourteen of these studies used Petersen criteria and other 3 used IWG criteria to define MCI. Thirteen of 17 studies included only aMCI and other 2 studies reported task performances of separate aMCI and naMCI groups.…”

Section: Resultsmentioning

confidence: 99%

“…However, in 2 studies that distinguished first- and second-order false belief tasks, MCI was associated with impairment only in second-order tasks. 21,23 Most individuals with MCI might fail only in cognitively more demanding ToM tasks due to deficits in nonsocial cognitive abilities such as executive dysfunction. In accordance with this notion, mild prefrontal neurodegeneration is evident in many patients with aMCI.…”

Section: Discussionmentioning

confidence: 99%

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Meta-Analysis of Social Cognition in Mild Cognitive Impairment

Bora

Yener

2017

J Geriatr Psychiatry Neurol

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Social cognitive abilities are impaired in Alzheimer disease and other dementias. Recent studies suggested that social cognitive abilities might be also impaired in mild cognitive impairment (MCI). Current meta-analysis aimed to summarize available evidence for deficits in theory of mind (ToM) and emotion recognition in MCI. In this meta-analysis of 17 studies, facial emotion recognition and ToM performances of 513 individuals with MCI and 693 healthy controls were compared. Mild cognitive impairment was associated with significant impairments falling in the medium effect sizes range in ToM ( d = 0.63) and facial emotion recognition ( d = 0.58). Among individual emotions, recognition of fear and sadness were particularly impaired. There were no significant between-group differences in recognition of disgust, happiness, and surprise. Social cognitive deficits were more severe in multidomain MCI. There is a need for longitudinal studies investigating the potential role of social cognitive impairment in predicting conversion to dementia.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of Social Cognition in Mild Cognitive Impairment

Bora

Yener

2017

J Geriatr Psychiatry Neurol

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“…The ability to draw inference was also impaired in our aMCI group and the performance was similar to that of the AD group. In a recent study, Gaudreau [49] showed that aMCI individuals were impaired in their mental inference capacity when compared to Controls. The aMCI group presented more difficulties to identify ironic or sincere stories.…”

Section: Discussionmentioning

confidence: 99%

Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer’s disease spectrum

Drummond

Coutinho

Monteiro

et al. 2019

Aging

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Background: Narrative discourse (ND) refers to one’s ability to verbally reproduce a sequence of temporally and logically-linked events. Impairments in ND may occur in subjects with Amnestic Mild Cognitive Impairment (aMCI) and Alzheimer’s Disease (AD), but correlates across this function, neuroimaging and cerebrospinal fluid (CSF) AD biomarkers remain understudied.Objectives: We sought to measure correlates among ND, Diffusion Tensor Imaging (DTI) indexes and AD CSF biomarkers in patients within the AD spectrum.Results: Groups differed in narrative production (NProd) and comprehension. aMCI and AD presented poorer inference abilities than controls. AD subjects were more impaired than controls and aMCI regarding WB (p<0.01). ROIs DTI assessment distinguished the three groups. Mean Diffusivity (MD) in the uncinate, bilateral parahippocampal cingulate and left inferior occipitofrontal fasciculi negatively correlated with NProd. Changes in specific tracts correlated with T-tau/Aβ1-42 ratio in CSF.Conclusions: AD and aMCI patients presented more ND impairments than controls. Those findings were associated with changes in ventral language-associated and in the inferior parahippocampal pathways. The latest were correlated with biomarkers’ levels in the CSF.Methods: AD (N=14), aMCI (N=31) and Control (N=39) groups were compared for whole brain (WB) and regions of interest (ROI) DTI parameters, ND and AD CSF biomarkers.

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“…This decline in cognitive functioning was first detected through participants’ complaints, which in turn were confirmed by a close relative. To confirm the presence of MCI, procedures similar to those adopted by Gaudreau et al (2015) were followed. Briefly, the MCI was confirmed based on a battery of clinical and neuropsychological tests that was administered.…”

Section: Methodsmentioning

confidence: 99%

Older Adults with Mild Cognitive Impairments Show Less Driving Errors after a Multiple Sessions Simulator Training Program but Do Not Exhibit Long Term Retention

Teasdale

Simoneau

Hudon

et al. 2016

Front. Hum. Neurosci.

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The driving performance of individuals with mild cognitive impairment (MCI) is suboptimal when compared to healthy older adults. It is expected that the driving will worsen with the progression of the cognitive decline and thus, whether or not these individuals should continue to drive is a matter of debate. The aim of the study was to provide support to the claim that individuals with MCI can benefit from a training program and improve their overall driving performance in a driving simulator. Fifteen older drivers with MCI participated in five training sessions in a simulator (over a 21-day period) and in a 6-month recall session. During training, they received automated auditory feedback on their performance when an error was noted about various maneuvers known to be suboptimal in MCI individuals (for instance, weaving, omitting to indicate a lane change, to verify a blind spot, or to engage in a visual search before crossing an intersection). The number of errors was compiled for eight different maneuvers for all sessions. For the initial five sessions, a gradual and significant decrease in the number of errors was observed, indicating learning and safer driving. The level of performance, however, was not maintained at the 6-month recall session. Nevertheless, the initial learning observed opens up possibilities to undertake more regular interventions to maintain driving skills and safe driving in MCI individuals.

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Mental State Inferences Abilities Contribution to Verbal Irony Comprehension in Older Adults with Mild Cognitive Impairment

Cited by 20 publications

References 44 publications

Meta-Analysis of Social Cognition in Mild Cognitive Impairment

Meta-Analysis of Social Cognition in Mild Cognitive Impairment

Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer’s disease spectrum

Older Adults with Mild Cognitive Impairments Show Less Driving Errors after a Multiple Sessions Simulator Training Program but Do Not Exhibit Long Term Retention

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