Mental–physical comorbidity in an ethnically diverse population

Scott, Kate M.; McGee, Magnus A.; Schaaf, David; Baxter, Joanne

doi:10.1016/j.socscimed.2007.11.022

Cited by 21 publications

(15 citation statements)

References 23 publications

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“…This pro-inflammatory cytokine is mainly produced by NK cells and CD4+ T cells, but macrophages have also been reported to secrete IFN-γ; the cellular source of this cytokine in our study remains to be elucidated. The finding of lower levels of serum anti-inflammatory cytokines IL-4 and IL-10 in GAD is similar to findings in patients with chronic pain where low IL-4 and IL-10 were found to be associated with increased pain perception (63), which may indicate a possible mechanism underlying the high association between pain and anxiety (64,65).…”

Section: Discussionsupporting

confidence: 82%

Peripheral inflammatory cytokines and immune balance in Generalised Anxiety Disorder: Case-controlled study

Hou

Garner

Holmes

et al. 2017

Brain, Behavior, and Immunity

148

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Introduction-Previous investigations have demonstrated that major depression is associated with particular patterns of cytokine signalling. The primary aim of this study was to examine peripheral pro-inflammatory and anti-inflammatory cytokines and immune balance in generalised anxiety disorder (GAD).Methods-A case-controlled cross-sectional study design was employed: 54 patients with GAD and 64 healthy controls were recruited. Participants completed self-report measures of anxiety and depression. Two pro-inflammatory and two anti-inflammatory cytokines were measured using multiplex technology.Results-Case-control logistic regression analyses revealed significant differences in serum levels of IL-10, TNF-α, and IFN-γ between GAD and control groups after adjusting for age, gender, body mass index, smoking and alcohol consumption: these group differences were independent of the presence or degree of depression. Comparison of pro-inflammatory to antiinflammatory cytokine ratios indicated that there were significantly higher ratios of TNF-α /IL10, TNF-α /IL4, IFN-γ /IL10, and IFN-γ /IL4 in the GAD group compared to the control group.Conclusions-This study is the first to investigate both pro-and anti-inflammatory cytokines and their balance in patients with GAD in comparison to healthy controls. The findings indicate a relatively increased pro-inflammatory response and decreased anti-inflammatory response and Europe PMC Funders Group Europe PMC Funders Author ManuscriptsEurope PMC Funders Author Manuscripts provide the first demonstration of an altered cytokine balance in GAD. Serum cytokine levels in GAD were independent of the presence of depression.

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Section: Discussionsupporting

confidence: 82%

Peripheral inflammatory cytokines and immune balance in Generalised Anxiety Disorder: Case-controlled study

Hou

Garner

Holmes

et al. 2017

Brain, Behavior, and Immunity

148

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“…The overall number of papers reviewed was 16; this was a tricky thing to count, however, as some of the papers were research reviews as opposed to actual studies (for example, Nelson, 2006), there were cases of multiple papers on one study (Fennell, 2005;Magnusson & Fennell, 2006, and there were four papers that mentioned pain only briefl y (which have not been included here). Quantitative research covered topics from: acute pain (Azariah, 1984;Mahmoud & Hill, 2006); pain associated with childbirth (Nelson, 2006); dental pain in children (Jamieson & Koopu, 2006); and prescription rates for analgesia (Crengle, Lay-Yee, Davis, & Pearson, 2005); to chronic pain (Dominick et al, 2011;Grace & Zondervan, 2004;Ministry of Health, 2008;Scott, McGee, Schaaf, & Baxter, 2008), fi bromyalgia (Klemp, Williams, & Stansfi eld, 2002), and musculoskeletal pain associated with rheumatic diseases (Taylor, Smeets, Hall, & McPherson, 2004). Qualitative research covered the topics of palliative pain (Penney, Fieldhouse, & Kerr, 2009), pain in physiotherapy patients (Bassett & Tango, 2002), and Mäori views on the experience of pain (Fennell, 2005;Magnusson & Fennell, 2006.…”

Section: Mäori and Pain: The Reviewmentioning

confidence: 99%

Māori and pain

McGavock

Barnes

McCreanor

2012

AlterNative: An International Journal of Indigenous Peoples

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Pain is subjective and is therefore a complex and diffi cult health issue to address. In-depth understanding is required for improvements to be made in how it is managed. Research suggests that culture plays a role in pain experiences, but very little such research has been conducted in Aotearoa (New Zealand). Signifi cant health disparities exist between Mäori (the indigenous people) and Päkehä (New Zealanders of European descent), and could also exist in pain experience. We reviewed the sparse, diverse literature on Mäori and pain and found patchy, inconsistent coverage, arising perhaps from the range of methodologies used and types of pain covered, with a distinct gap around chronic pain. Although pain is a signifi cant area of Mäori health, none of the research explored the lived experience of pain from a Mäori perspective. The need for indepth research using a Kaupapa Mäori (Mäori theory) approach to address this under-researched issue is discussed.

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“…Patients with mental disorders display a high comorbidity of physical conditions such as respiratory, metabolic, cardio-vascular and neurologic diseases [17,18]. Many of the conditions named above are linked to overweight, smoking, and unhealthy lifestyle [19]; therefore lifestyle interventions based on nutrition and EX are promising approaches for reducing physical comorbidity [20].…”

Section: Introductionmentioning

confidence: 99%

Exercise and Physical Activity in Mental Disorders: Clinical and Experimental Evidence

Zschucke

Gaudlitz

Ströhle

2013

J Prev Med Public Health

209

115

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Several epidemiological studies have shown that exercise (EX) and physical activity (PA) can prevent or delay the onset of different mental disorders, and have therapeutic benefits when used as sole or adjunct treatment in mental disorders. This review summarizes studies that used EX interventions in patients with anxiety, affective, eating, and substance use disorders, as well as schizophrenia and dementia/mild cognitive impairment. Despite several decades of clinical evidence with EX interventions, controlled studies are sparse in most disorder groups. Preliminary evidence suggests that PA/EX can induce improvements in physical, subjective and disorder-specific clinical outcomes. Potential mechanisms of action are discussed, as well as implications for psychiatric research and practice.

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Mental–physical comorbidity in an ethnically diverse population

Cited by 21 publications

References 23 publications

Peripheral inflammatory cytokines and immune balance in Generalised Anxiety Disorder: Case-controlled study

Peripheral inflammatory cytokines and immune balance in Generalised Anxiety Disorder: Case-controlled study

Māori and pain

Exercise and Physical Activity in Mental Disorders: Clinical and Experimental Evidence

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