Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic: a preliminary report based upon interviews with the relatives

Kety, Seymour S.; Rosenthal, David; Wender, Paul H.; Schulsinger, Fini; Jacobsen, B.

doi:10.1016/0022-3956(74)90042-9

Cited by 74 publications

(90 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Schizotypal personality disorder (SPD) is characterized by oddities in appearance, perception and behavior that appear to represent a milder variant of schizophrenia (Kety et al, 1975). We previously studied a wide range of cognitive functions in a small group of men who met full diagnostic criteria for SPD, and found significant deficits on measures of verbal learning and abstraction (Voglmaier et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorder

Voglmaier

Seidman

Niznikiewicz

et al. 2005

Schizophrenia Research

View full text Add to dashboard Cite

The purpose of this study was to compare the cognitive profiles of men and women with clinically defined schizotypal personality disorder (SPD). We examined the neuropsychological profile of SPD in 26 right-handed females and 31 right-handed males who met DSM-IV criteria for SPD, and matched comparison subjects. Cognitive performance was assessed on measures of abstraction, verbal and spatial intelligence, learning and memory, language, attention, and motor skills. Neuropsychological profiles were constructed by standardizing test scores based on the means and standard deviations of comparison groups matched for sex, age, handedness, ethnicity and parental SES. Overall, SPD subjects showed mild, general decrements in performance in most cognitive domains. However, unlike male SPD subjects, female SPDs did not show relative deficits in verbal learning and abstraction. The results suggest a less severe pattern of cognitive deficits in women with SPD compared to men, consistent with hypotheses of gender differences in cognitive function in schizophrenia.

show abstract

Section: Introductionmentioning

confidence: 99%

A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorder

Voglmaier

Seidman

Niznikiewicz

et al. 2005

Schizophrenia Research

View full text Add to dashboard Cite

show abstract

“…Until the Danish Adoption studies of Kety, Rosenthal, and Wender (Kety, Rosenthal, Wender, & Schulsinger, 1968;Kety, Rosenthal, Wender, Schulsinger, & Jacobsen, 1975;Kety, 1983Kety, , 1985Kety, , 1987Rosenthal, Wender, Kety, Welner, & Schulsinger, 1971;Kendler, Gruenberg, & Strauss, 1981;Kendler & Gruenberg, 1984), no spectrum category had a compelling empirical foundation. The Danish studies provided evidence for the range of phenotypic expression of a putative genotype, subsequently called schizotypal personality disorder (STPD) in DSM-III (1980) and DSM-III-R (1987).…”

Section: Introductionmentioning

confidence: 99%

DSM-III-R schizotypal personality traits in offspring of schizophrenic disorder, affective disorder, and normal control parents

Squires-Wheeler¹,

Skodol²,

Bassett³

et al. 1989

Journal of Psychiatric Research

View full text Add to dashboard Cite

SummaryThe aggregation of disorder in families identified by a schizophrenic disorder proband (index case) has provided indirect clues to the question of diagnostic boundaries of schizophrenic spectrum categories. The Danish Adoption Studies provided quasi-experimental evidence for the range of expression of a putative schizophrenic spectrum disorder which was subsequently denoted schizotypal personality disorder (STPD) in DSM-III-R. It has been hypothesized that such schizophrenic spectrum categories bear a genetic relationship to schizophrenic disorder and thus are continuous with schizophrenia in terms of etiology and pathogenesis. For meaningful use of such spectrum categories in genetic analyses, e.g., linkage analysis, it is important that rates of spectrum traits and disorder in normal control and in psychiatric control populations are known. The rate of DSM-III-R schizotypal traits and disorder was assessed in three offspring groups (ages 18-29) defined by parental diagnoses, including schizophrenic disorder (N = 90), affective disorder (N = 79), and no parental disorder (N = 161). The assessment was conducted by trained social workers and psychologists by means of a direct interview (Personality Disorder Examination). The interviewers were blind to the parental status and to previous psychiatric assessments of these offspring. The rates of three, four and five schizotypal features were elevated in the offspring with parental psychiatric disorder in contrast to the offspring with no parental psychiatric disorder. However, the rates between the offspring of the schizophrenic disorder parental group and the offspring of the affective disorder parental group did not differ significantly, thus failing to support the assumption of diagnostic specificity.

show abstract

“…Ainsi, les étu-des d'adoption menées conjointement par les Amé-ricains et les Danois (Kety, Rosenthal et Wender 1975) ont montré que les enfants de parents schizophrènes adoptés par des parents normaux sont plus souvent atteints de schizophrénie que : 1. les enfants de parents biologiques normaux et adoptés par des parents normaux ; 2. les enfants de parents biologiques normaux et adoptés par des parents qui ont manifesté ultérieurement des symptômes de schizophrénie. On a remarqué, dans le deuxième cas, que les enfants qui n'ont pas de bagage génétique de schizophrénie ne semblent pas subir l'influence des troubles schizophréniformes de leurs parents adoptifs.…”

Section: éTudes Génétiquesunclassified

La famille du schizophrène : interférente ou alliée?

Boucher¹,

Lalonde²

2006

smq

View full text Add to dashboard Cite

Résumé Nous avons fait un tour d'horizon des différentes études qui, dans la seconde moitié de notre siècle, ont été faites sur la famille du schizophrène. Les premières études, plus descriptives, cherchaient à établir l'étiologie de la schizophrénie ; elles identifiaient la famille comme étant une des principales causes de la maladie. Par la suite, le raffinement de la méthodologie et l'apport des études génétiques ont amené les chercheurs à considérer la famille d'un point de vue différent. La famille apparaît désormais comme un facteur important mais elle est liée aux facteurs environnementaux subtils et complexes qui restent encore à déterminer. Les chercheurs tendent maintenant à privilégier une approche qui permette à la famille de jouer un rôle actif face à l'évolution de la maladie. On perçoit de plus en plus la famille comme une alliée potentielle du malade et on s'efforce de l'associer au traitement. C'est du moins le but poursuivi par les tenants de l'approche psychoéducative, et les résultats thérapeutiques semblent, à l'heure actuelle, des plus encourageants.

show abstract

Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic: a preliminary report based upon interviews with the relatives

Cited by 74 publications

References 0 publications

A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorder

A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorder

DSM-III-R schizotypal personality traits in offspring of schizophrenic disorder, affective disorder, and normal control parents

La famille du schizophrène : interférente ou alliée?

Contact Info

Product

Resources

About