Mental health services? maintaining strategic direction

Farrington,

doi:10.1046/j.1365-2834.1998.00083.x

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…Erythromycin, a macrolide antibiotic, has been an effective bactericidal agent for over 50 years [25][26][27][28] and is often used as an alternative to penicillin. 28 In an effort to strengthen the chemical stability and pharmacokinetic properties of the compound, analogues to erythromycin are being developed to promote stability, improved ADME (Absorption, Distribution, Metabolism, and Excretion) properties, and elude bacterial resistance mechanisms. 25,26,28,29 The high dissociation MS/MS data for erythromycin is shown in Fig.…”

Section: Erythromycin Dissociationmentioning

confidence: 99%

“…28 In an effort to strengthen the chemical stability and pharmacokinetic properties of the compound, analogues to erythromycin are being developed to promote stability, improved ADME (Absorption, Distribution, Metabolism, and Excretion) properties, and elude bacterial resistance mechanisms. 25,26,28,29 The high dissociation MS/MS data for erythromycin is shown in Fig. 4.…”

Section: Erythromycin Dissociationmentioning

confidence: 99%

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The STEP method (statistical test of equivalent pathways): application to pharmaceuticals

Bandu

Desaire

2006

Analyst

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The STEP method (Statistical Test of Equivalent Pathways), recently developed to determine primary and secondary fragmentation in the MS/MS of peptides and carbohydrates, is applied in the current study to common pharmaceutical antibiotics. The classification of product ions as primary or secondary is then utilized to construct genealogy diagrams that aid in the structural characterization of the product ions. Four compounds were subjected to the MS/MS conditions used for the STEP method, and the method was used to correctly identify primary and secondary ions in three of the four pharmaceuticals. Calculated STEP values for erythromycin did not match previously characterized fragmentation assignments. This provided an opportunity to explore potential limitations of STEP analysis. It was determined that inaccurate STEP assignments could result, if the starting compound is classified as "fragile", because fragile ions, such as erythromycin can produce abnormally low STEP ratios. While this finding represents a limitation of using the STEP method to determine whether product ions are due to primary or secondary fragmentation for fragile ions, it suggests the possibility of identifying the presence of "fragile ions" by STEP analysis.

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Section: Erythromycin Dissociationmentioning

confidence: 99%

Section: Erythromycin Dissociationmentioning

confidence: 99%

The STEP method (statistical test of equivalent pathways): application to pharmaceuticals

Bandu

Desaire

2006

Analyst

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A comparison of the work and values of community mental health nurses in two mental health NHS Trusts

Nolan

Haque

Bourke

et al. 2004

Psychiatric Ment Health Nurs

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With the reconfiguration of health services in both the primary and secondary sectors, the role of community mental health nurses (CMHNs) has become a highly contested one within mental health care. There would be great variability in the skills that CMHNs possess, the contexts in which they work and the nature of the work they do. This study sought to explore aspects of the work of those nurses who provide services at the interface between policy and practice. Two groups of CMHNs were compared, one working in an urban setting (Trust A) and the other in a rural (Trust B), focusing particularly on caseloads and client mix, the values held by CMHNs, the models of care they utilize and what they consider would improve care in the future. A specially designed 39-item questionnaire was employed, with a mix of open and closed questions, and statements to which participants were asked to respond on a three-point Likert scale. The findings raised interesting issues around collaborative working, whether CMHNs are happy to take on clients previously on their caseload, bureaucratization, autonomy, role definition within a culture of working with primary care, lack of specific models utilized by CMHNs, and the demand for greater training and educational support. The implications of the study are discussed with the aim of assisting mental health nurses determine their future roles.

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Knowledge is power: using nursing information management and leadership interventions to improve services to patients, clients and users

Phillips

2005

J Nurs Manag

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The conclusion is that sustained quality information could be embedded in nursing practice at Yelday Lodge or elsewhere by evaluating and discussing the different information management approaches within the practice area through the use of structured management and leadership interventions. The use of the CLINLAP model is recommended for use as a model for managing information, knowledge and communication for results within nursing and health care services.

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Mental health services? maintaining strategic direction

Cited by 3 publications

References 3 publications

The STEP method (statistical test of equivalent pathways): application to pharmaceuticals

The STEP method (statistical test of equivalent pathways): application to pharmaceuticals

A comparison of the work and values of community mental health nurses in two mental health NHS Trusts

Knowledge is power: using nursing information management and leadership interventions to improve services to patients, clients and users

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