Mental Health Problems of Army Personnel Seen in Medical Outpatient Clinics in Greece

Argyropoulos, Ioannis Th.; Samakouri, Maria; Balascas, Dimitrios K.; Dalapascha, Melpomeni; Pallas, Dimitrios P.; Livaditis, Miltos

doi:10.2190/b6xn-w4ct-ypv0-6jfe

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…Depending on the severity of symptoms, 60%–90% of patients with a major depressive episode present with disturbed sleep (Argyropoulos et al, 2005). Notwithstanding, acute sleep deprivation ‐ or “wake therapy” ‐ improves depressive symptoms in ~60% of all patients (Wirz‐Justice & Van den Hoofdakker, 1999).…”

Section: Possible Novel Approaches Targeting the Adenosinergic System...mentioning

confidence: 99%

Adenosine, caffeine, and sleep–wake regulation: state of the science and perspectives

Reichert

Deboer

Landolt

2022

Journal of Sleep Research

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Summary For hundreds of years, mankind has been influencing its sleep and waking state through the adenosinergic system. For ~100 years now, systematic research has been performed, first started by testing the effects of different dosages of caffeine on sleep and waking behaviour. About 70 years ago, adenosine itself entered the picture as a possible ligand of the receptors where caffeine hooks on as an antagonist to reduce sleepiness. Since the scientific demonstration that this is indeed the case, progress has been fast. Today, adenosine is widely accepted as an endogenous sleep‐regulatory substance. In this review, we discuss the current state of the science in model organisms and humans on the working mechanisms of adenosine and caffeine on sleep. We critically investigate the evidence for a direct involvement in sleep homeostatic mechanisms and whether the effects of caffeine on sleep differ between acute intake and chronic consumption. In addition, we review the more recent evidence that adenosine levels may also influence the functioning of the circadian clock and address the question of whether sleep homeostasis and the circadian clock may interact through adenosinergic signalling. In the final section, we discuss the perspectives of possible clinical applications of the accumulated knowledge over the last century that may improve sleep‐related disorders. We conclude our review by highlighting some open questions that need to be answered, to better understand how adenosine and caffeine exactly regulate and influence sleep.

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Section: Possible Novel Approaches Targeting the Adenosinergic System...mentioning

confidence: 99%

Adenosine, caffeine, and sleep–wake regulation: state of the science and perspectives

Reichert

Deboer

Landolt

2022

Journal of Sleep Research

View full text Add to dashboard Cite

show abstract

Parent and Adolescent Positive and Negative Disability-Related Events and Their Relation to Adjustment

Mazur

2010

Risk and Resilience in U.S. Military Families

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Men, depression and masculinities: A review and recommendations

Oliffe¹,

Phillips²

2008

Journal of Men's Health

207

176

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Mental Health Problems of Army Personnel Seen in Medical Outpatient Clinics in Greece

Abstract: A large number of military personnel present undiagnosed psychological problems despite attempts in the last few years by army services to develop mechanisms of timely diagnosis and treatment of psychiatric cases. Measures for the improvement of this situation are discussed.

Cited by 4 publications

References 41 publications

Adenosine, caffeine, and sleep–wake regulation: state of the science and perspectives

Adenosine, caffeine, and sleep–wake regulation: state of the science and perspectives

Parent and Adolescent Positive and Negative Disability-Related Events and Their Relation to Adjustment

Men, depression and masculinities: A review and recommendations

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