S martphone users can now download apps that claim to help them improve their health by assisting them in modifying self-defeating behaviors. This is a positive step toward self-empowerment, but in order for these apps to realize their full potential, they must be not only well designed and diligently social media marketed, but also proven effective and cost-effective through evidence-based research. Only then will they become mainstream adjuncts to clinical practice.A recent review of mental health apps concluded that ''the majority of apps that are currently available lack scientific evidence about their efficacy,'' citing sleep disturbance, anxiety disorders, and smoking cessation as areas particularly lacking in evidence-based research support. 1 Another review of self-management apps found only one randomized clinical trial (RCT) among 2,969 abstracts. 2 A broader review of health apps revealed that although the apps were informed by behavioral theories or strategies, the applicability of any effectiveness study results was limited by small sample sizes. 3 As an example, although depression is the leading cause of disability worldwide, 4 no large-scale studies have been published that show the efficacy of apps designed to work adjunctively to therapy to treat this common condition. A recent review found 1,054 depression apps-primarily focused on treatment but also on education-available in the online stores for the five most common smartphone platforms. 5 Yet, only one pilot RCT has been conducted with a depression app. It found that both the smartphone/tablet and computer groups were associated with statistically significantly benefits in the PHQ-9 (Patient Health Questionnaire, 9 questions) at post-test and at 3 month follow-up. 6 The authors suggested a larger sample size and the addition of a control group. Researchers in the Netherlands have since created such a study design and protocol, but to date study results have not been published. 7 Behavioral health apps are promising enough to warrant incorporation into standard treatment, according to some of our colleagues. 8 However, there is a need to train clinicians on how to incorporate these apps into our practices. 9 Other colleagues believe that both clinical trials and citizen science will prove the efficacy of these apps. 10 Some researchers have proposed a methodologic framework, Continuous Evaluation of Evolving Behavioral Intervention Technologies, to help bridge the gap between the rapid changes in technology and attendant consumer expectations versus the longer timeline required for efficacy studies. 11As clinical research professionals, we know how timeconsuming it is to write research protocols and grant applications, get them approved and funded, recruit study participants, analyze data, and write up results and have them accepted for presentation and publication. However, a recent presentation outlined ways in which RCTs may actually be beneficial, allowing us to complete trials more rapidly and more cost effectively. Reasons for this incl...