Changing economics gave rise to the development of Multi-Hospital Information Systems (MHISs) serving systems of three or more hospitals and their associated services. Functional and technical capabilities, including translational databases, were developed to support the exchange and integration of multiple forms of information within and among facilities. Early examples in the private sector included MHISs at The Sisters of the Third Order of St. Francis (1960s) and Intermountain Health Care (1970s), and in mental health hospitals (1960s-1970s). In the federal sector, the U.S. Public Health Service and Indian Health Services began to develop MHISs in the 1970s. Efforts to use automation to support services started in the 1960s at the Department of Defense, which used a top down approach, and Veterans Administration, which worked bottom up; the complicated histories of these developments spanned decades. Also in the MHIS marketplace were com-