Mental health disorders among ovarian cancer survivors in a population‐based cohort

Hu, Siqi; Baraghoshi, David; Chang, Chun‐Pin; Rowe, Kerry; Snyder, John; Deshmukh, Vikrant; Newman, Michael G.; Fraser, Alison; Smith, Ken R.; Peoples, Anita R.; Gaffney, David K.; Hashibe, Mia

doi:10.1002/cam4.4976

Cited by 11 publications

(7 citation statements)

References 36 publications

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Section: Discussionmentioning

confidence: 99%

“…OC patients experience depression, anxiety, and reduced quality of life due to fear of recurrence, persistent fatigue, sexual inactivity, and repetitive treatment cycles [ 15 , 45 ]. The incidence of anxiety disorders among OC patients/survivors is approximately 3.5 times higher in the first 2 years following diagnosis [ 45 ]. Although the anxiety levels of the OC survivors in our study were significantly higher than the healthy controls, HADS-A scores were lower than the previously reported cut-off scores (a cut-off score > 9 is used to identify higher anxiety for cancer patients) [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

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The comparison of functional status and health-related parameters in ovarian cancer survivors with healthy controls

Gultekin,

Cakir,

Guc

et al. 2024

Support Care Cancer

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Purpose The primary purpose of this study was to evaluate functional status and health-related parameters in ovarian cancer (OC) survivors and to compare these parameters with healthy controls. The secondary purpose of this study was to compare these parameters in early and advanced OC survivors. Methods Thirty-two OC survivors (n = 15 early stage; n = 17 advanced stage) with no evidence/suspicion of cancer recurrence after completing adjuvant local and systemic treatments for at least 12 months and 32 healthy controls were recruited for functional- and health-related assessments. Participants were assessed using the following methods of measuring the following: 6-min walk test (6MWT) for functional exercise capacity, 30-s chair stand test (30 s-CST) for functional fitness and muscle endurance, a handheld dynamometer for peripheral muscle strength, and a handheld dynamometer for lower extremity strength, Medical Micro RPM for respiratory muscle strength, International Physical Activity Questionnaire-Short Form (IPAQ-SF) for physical activity level, and Eastern Cooperative Oncology Group Performance Scale (ECOG-PS) for performance status, Checklist Individual Strength (CIS) for fatigue, Treatment/Gynecological Oncology-Neurotoxicity (FACT/GOG-NTX) for neuropathy, the Hospital Anxiety and Depression Scale (HADS) for anxiety and depression level, and the World Health Organization-Five Well-Being Index (WHO-5) for generic quality of life. Results All OC survivors underwent surgery and chemotherapy, and only 9.4% received radiotherapy in addition to chemotherapy. The median recurrence-free period post-completion of adjuvant treatments was 24.00 (12.00–75.00) months. OC survivors had lower 6MWT (m) (p < 0.001, r = 1.50), peripheral muscle strength (p = 0.005, r = 0.72), knee extension (p < 0.001, r = 1.54), and respiratory muscle strength (maximal inspiratory pressure) (p < 0.001, r = 1.90) (maximal expiratory pressure) (p < 0.001, r = 1.68) compared to healthy controls. HADS-A (p = 0.005, r = 0.75) and CIS scores (p = 0.025, r = 0.59) were also higher in the OC survivors. Early-stage OC survivors had better 6MWT (m) than advanced-stage OC survivors (p = 0.005, r = 1.83). Peripheral muscle strength was lower in advanced-stage OC survivors (p = 0.013, r = 0.92). FACT/GOG-NTX scores were higher in early-stage OC survivors (p < 0.001, r = 1.42). No significant differences were observed between early- and advanced-stage OC survivors in other measures (p < 0.05). Conclusion The findings suggest functional status, and health-related parameters are negatively affected in OC survivors. Additionally, higher levels of fatigue, neuropathy anxiety, and depression were reported in advanced OC survivors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The comparison of functional status and health-related parameters in ovarian cancer survivors with healthy controls

Gultekin,

Cakir,

Guc

et al. 2024

Support Care Cancer

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“…1 Factors that may contribute to developing anxiety or depression include the diagnosis experience, tumour prognosis and curability, treatment-related side effects, fear of cancer recurrence, and the financial toxicity associated with cancer and its treatment. 2 In particular, anxiety and depression are common among women with ovarian cancer, 3,4 who face a poorer prognosis and a higher risk of disease recurrence compared to other cancer types. 5,6 Furthermore, poor nutritional status has been associated with anxiety and depression among cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Mental health and diet quality after primary treatment for ovarian cancer

Johnston,

Veenhuizen,

Ibiebele

et al. 2024

Nutrition & Dietetics

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AimsTo investigate anxiety and depression after primary treatment for ovarian cancer in relation to diet quality and intake.MethodsIn a cohort of women with ovarian cancer in Australia, levels of anxiety and depression (normal, subclinical, and clinical) were assessed using the Hospital Anxiety and Depression Scale at 9 months post‐diagnosis. Dietary intake was assessed using a validated food frequency questionnaire at 12 months post‐diagnosis and scored using the Healthy Eating Index 2015. Multinomial logistic regression and bivariate analyses were used to investigate relationships between levels of anxiety and depression and subsequent diet quality and intake of food groups.ResultsOf 595 women, anxiety and depression were identified among 128 (21%) and 80 (13%) women, respectively. Compared to women without anxiety or depression, women with subclinical anxiety (odds ratio = 0.49, 95% confidence interval: 0.25–0.98) and those with clinical depression (odds ratio = 0.25, 95% confidence interval: 0.07–0.93) were less likely to score in the highest quartile for diet quality. Separate adjustment for age, education, employment, disease stage, body mass index, and smoking status did not attenuate these associations. In bivariate analyses, women with subclinical anxiety were more likely to report higher intakes of sweet foods. Those with clinical depression were more likely to report lower intakes of orange vegetables and wholegrains, higher intakes of sweetened beverages, and not consume alcohol or soya foods.ConclusionsAnxiety or depression after primary treatment for ovarian cancer may be associated with poorer diet quality. Efforts to improve diet quality post‐treatment should consider support for mental health.

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“…[1][2][3][4] Reports of childhood and adult trauma (emotional, physical, and sexual) with associated post traumatic stress disorder vary, however, are common in people with persistent pelvic pain. [5][6][7][8] In addition, persons with polycystic ovarian syndrome, urinary incontinence, and prolapse experience higher rates of depression and diminished health-quality life [9][10][11] Furthermore, persons with ovarian cancer experience higher rates of depression 12 and women with cancer often report diminished sexual health (eg, decreased desire, vaginal dryness, dyspareunia, and anorgasmia). 13 Although patients coping with these biopsychosocial challenges would benefit from behavioral health screening, treatment, and prevention inventions, access to mental health care and sex therapy is difficult in general and, especially, in any number of marginalized, rural, and frontier communities.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, persons with polycystic ovarian syndrome, urinary incontinence, and prolapse experience higher rates of depression and diminished health-quality life 9–11 Furthermore, persons with ovarian cancer experience higher rates of depression 12 and women with cancer often report diminished sexual health (eg, decreased desire, vaginal dryness, dyspareunia, and anorgasmia) 13 …”

Section: Introductionmentioning

confidence: 99%

Integrated Care for Persons With Persistent Gynecologic Conditions

Witzeman,

Lieberman,

Beckman

et al. 2023

Clinical Obstetrics &Amp; Gynecology

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Persons with persistent gynecologic conditions frequently cope with complex biopsychosocial challenges and benefit from integrated behavioral health evaluation and treatment within gynecologic practices. Integrated care refers to the provision of behavioral health services within a health care setting which contributes to improved patient, provider, and practice outcomes, however, has not been commonly provided in traditional gynecologic practices. Several models of integrated behavioral health are reviewed. Each model holds specific applications in primary and specialty gynecology settings and may enhance the gynecologic patient experience. This article reviews current research supporting integrated care and describes implementation, funding, and evaluation to improve patient outcomes.

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Mental health disorders among ovarian cancer survivors in a population‐based cohort

Cited by 11 publications

References 36 publications

The comparison of functional status and health-related parameters in ovarian cancer survivors with healthy controls

The comparison of functional status and health-related parameters in ovarian cancer survivors with healthy controls

Mental health and diet quality after primary treatment for ovarian cancer

Integrated Care for Persons With Persistent Gynecologic Conditions

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