Mental health and quality of life of patients with osteoarthritis pain: The sixth Korea National Health and Nutrition Examination Survey (2013–2015)

Abstract

Objectives This study aims to investigate the association between mental health and quality of life of osteoarthritis (OA) patients according to the site of pain. Design Retrospective cross-sectional study Participants Data of 22,948 participants of the sixth Korea National Health and Nutrition Examination Survey conducted from 2013–2015 were used. Outcome measures Participants were asked if they had OA pain in the hip joint, knee joint, and lower back (yes/no) and whether they experienced anxiety or depression. The EQ-5D questionnaire was used to determine the quality of life of patients with hip, knee, and lower back OA. Multiple logistic regression analysis was performed after adjusting. Results A total of 5,401 patients reported pain in the hip joint, knee joint, or lower back. The analysis showed significant relations between pain sites, mental health, and quality of life. First, more female patients with OA experienced stress and depression than males. Second, for males with OA, stress was reported in the order of: lower back > hip > knee, while pain and depression was reported in the order of: lower back > knee > hip (p < 0.05). For females with OA, stress was reported in the order of: knee > lower back > hip, while depression was reported in the order of: knee > lower back > hip. Third, considering quality of life, for males, hip joint pain had the greatest impact on quality of life and for females, knee joint pain had the largest impact (p < 0.001). Conclusions For patients with OA, the effect on the mental health and quality of life differed according to sex and sites of pain. Therefore, this study confirms that pain sites, sex, mental health, and quality of life are independent risk factors when determining OA pain.

Health-related quality of life of Malaysian patients with chronic non-malignant pain and its associated factors: a cross-sectional study

“…Apart from ethnicity, this study also revealed that individuals who experienced pain involving back to lower limb region have a poorer HRQoL. This is consistent with the previous studies which suggest that HRQoL among patients with low back and knee pain is generally poorer [ 38 – 40 ]. Pain in the back and lower limbs commonly limits one’s physical function and mobility [ 41 , 42 ], and affects one’s capacity to work [ 43 ].…”

The impact of pain on quality of life in patients with osteoarthritis: a cross-sectional study from Palestine

“…Pain is the symptom that forces patients to seek medical advice and contributes the most to functional limitations and reduced quality of life [ 3 ]. Specifically, the impact of OA on the quality of life was found to be significantly associated with the sites of pain and sex [ 4 ].…”

Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes

“…Metformin was found to effectively alleviate cartilage degradation and chondrocyte senescence by enhancing the polarization of AMPK and inhibiting mTORC1 [143]. miR-140 was shown to inhibit the expression of SA-β-Gal, p16 INK [4] a , and p21, effectively retarding chondrocyte senescence and attenuating the progression of OA [144]. Therefore, we speculate that OA chondrocytes are not senescent cells in the formal definition as they can proliferate in vitro.…”

“…It has been estimated that the medical costs of OA account for about 1% to 2.5% of the US national gross domestic product and this number is expected to rise further with an aging population and the obesity epidemic [ 3 ]. In addition to physical impedance, OA also causes psychological stress, which may ultimately lead to social isolation and mental stress [ 4 ]. To date, there are no disease-modifying OA drugs (DMOADs) available to delay or reverse OA progression.…”