Mental health and psychosocial adjustment in pediatric chronic kidney disease derived from the KNOW-Ped CKD study

Kang, Na Ri; Ahn, Yo Han; Park, Eujin; Choi, Hyun Jin; Kim, Seong Heon; Cho, Heeyeon; Cho, Min Hyun; Smıth, Lee; Lee, Joo Hoon; Park, Young-Seo; Cheong, Hae Il; Kang, Hee Gyung; Ha, Il Soo; Kwack, Young Sook; Han, Kyoung Hee

doi:10.1007/s00467-019-04292-w

Cited by 26 publications

(17 citation statements)

References 45 publications

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“…In addition, patients with CAKUT often have extrarenal manifestations as well, such as hearing loss, neurocognitive disorders, and cardiac anomalies, which affect growth and development. Therefore, many children with CKD resulting from CAKUT experience extrarenal manifestations besides the long-standing CKD, which may also lead to complications such as impairments in physical and psychosocial development [3][4][5] as well as high morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Targeted Exome Sequencing Provided Comprehensive Genetic Diagnosis of Congenital Anomalies of the Kidney and Urinary Tract

Ahn

Lee

Kim

et al. 2020

JCM

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Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease in children. The search for genetic causes of CAKUT has led to genetic diagnosis in approximately 5–20 % of CAKUT patients from Western countries. In this study, genetic causes of CAKUT in Korean children were sought using targeted exome sequencing (TES) of 60 genes reported to cause CAKUT in human or murine models. We identified genetic causes in 13.8% of the 94 recruited patients. Pathogenic single nucleotide variants of five known disease-causing genes, HNF1B, PAX2, EYA1, UPK3A, and FRAS1 were found in 7 cases. Pathogenic copy number variations of 6 patients were found in HNF1B, EYA1, and CHD1L. Genetic abnormality types did not significantly differ according to CAKUT phenotypes. Patients with pathogenic variants of targeted genes had syndromic features more frequently than those without (p < 0.001). This is the first genetic analysis study of Korean patients with CAKUT. Only one-seventh of patients were found to have pathogenic mutations in known CAKUT-related genes, indicating that there are more CAKUT-causing genes or environmental factors to discover.

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Section: Introductionmentioning

confidence: 99%

Targeted Exome Sequencing Provided Comprehensive Genetic Diagnosis of Congenital Anomalies of the Kidney and Urinary Tract

Ahn

Lee

Kim

et al. 2020

JCM

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“…Many young people with chronic and/or life-threatening conditions (eg, cystic fibrosis, end stage renal failure and congenital cardiac conditions) now survive into adulthood. Failure to recognise and manage the mental health needs of this population can impact on clinical care, engagement with medical teams and quality of life 7–10. Conversely, early identification of children and young adults who present with mental health issues in the hospital setting would allow prompt assessment and management of emerging issues.…”

Section: Objectivementioning

confidence: 99%

Feasibility of single question mental health surveillance in chronic disease

et al. 2022

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ObjectiveTo determine the (1) feasibility and acceptability of administering single question mental health surveillance to carers of children with chronic disease in the inpatient setting and (2) sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of this question to detect ‘at risk’ children compared with the Strengths and Difficulties Questionnaire (SDQ).DesignCross-sectional pilotSettingDay Medical Unit of a tertiary paediatric hospital, 1 April 2021–31 July 2021.PatientsCarers of children aged 2–17 years with chronic medical conditions.InterventionsCaregivers were asked to respond to ‘Thinking about your child’s mental health over the past 4 weeks, are they thriving/coping/struggling/always overwhelmed?’ during the admission process. All carers and children 11–17 years were invited to complete the SDQ.Main outcome measuresFeasibility and acceptability were determined by nursing feedback. Sensitivity, specificity, PPV and NPV were determined by comparing question responses with clinical cut-points on the SDQ.Results213 carers responded to the question. Nurses reported that the question was easy (12/14) or moderately easy (2/14) to use and was ‘easily understood’ (6/14) or ‘understood after some explanation’ (8/14) for most carers. The question demonstrated a high specificity (0.98)/PPV (0.87) but low sensitivity (0.2) when thriving/coping were considered together whereas when thriving was compared with all other responses the sensitivity increased to 0.7.ConclusionsSingle question mental health surveillance appears acceptable to carers and nursing staff and has a high level of specificity for children who are ‘struggling’ or ‘always overwhelmed’ versus the SDQ screening measure.

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“…In a recent analysis from the Kids with CKD study, among 375 children from Australia and New Zealand with CKD, on dialysis and after kidney transplantation (KT), quality of life scores were significantly lower among dialysis patients, and short stature was associated with poorer quality of life [14]. Children with short stature more often have emotional and behavioral problems, including anxiety, low self-esteem, social immaturity, learning disabilities, and poor academic achievement [15,16]. One-third of adult patients with childhood onset CKD 5 were dissatisfied with their body height [17], and a Dutch cohort study found that patients starting KRT < 15 years of age who attained a short adult height were less likely to have children after 30 years on KRT [18].…”

Section: Association Of Growth Retardation With Outcomesmentioning

confidence: 99%

Growth in children on kidney replacement therapy: a review of data from patient registries

et al. 2021

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Growth retardation is a major complication in children with chronic kidney disease (CKD) and on kidney replacement therapy (KRT). Conversely, better growth in childhood CKD is associated with an improvement in several hard morbidity–mortality endpoints. Data from pediatric international registries has demonstrated that improvements in the overall conservative management of CKD, the search for optimal dialysis, and advances in immunosuppression and kidney transplant techniques have led to a significant improvement of final height over time. Infancy still remains a critical period for adequate linear growth, and the loss of stature during the first years of life influences final height. Preliminary new original data from the European Society for Paediatric Nephrology/European Renal Association-European Dialysis and Transplant Association (ESPN/ERA-EDTA) Registry confirm an association between the final height and the height attained at 2 years in children on KRT.

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Mental health and psychosocial adjustment in pediatric chronic kidney disease derived from the KNOW-Ped CKD study

Cited by 26 publications

References 45 publications

Targeted Exome Sequencing Provided Comprehensive Genetic Diagnosis of Congenital Anomalies of the Kidney and Urinary Tract

Targeted Exome Sequencing Provided Comprehensive Genetic Diagnosis of Congenital Anomalies of the Kidney and Urinary Tract

Feasibility of single question mental health surveillance in chronic disease

Growth in children on kidney replacement therapy: a review of data from patient registries

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