The thesis consists of three scientific papers. The content of the thesis is primarily intended for epidemiologists and clinicians.The PhD thesis would not have been possible without the support and guidance from people I would like to acknowledge here. First and foremost, I would like to thank my main supervisor, Tarec El-Galaly, for the opportunity to work as a PhD student at the Department of Hematology. Your encouragement, guidance, and faith in me throughout the years as well as pushing me beyond limits have made sure, that I advanced my skills as a researcher. You have always found time to help and guide me day or night and sharing your network with me, for which I'm grateful.My thanks also go to Marianne Severinsen, who have acted as both assistant and main supervisor during my time as a PhD-student, and as main supervisor during my master thesis in 2015. I'm grateful for your guidance throughout the years, and for always making sure that I took the time to take a breath when taking on too many assignments.
4understanding throughout the years and for listening to my enthusiastic talks on recent results. Last but not least, a heartfelt thanks to my beloved Michelle. Without your love, support, and understanding throughout the years this would not have been possible.