Abstract:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory tract, but sometimes also other organs, including the central nervous system (CNS). It is not well understood how the virus affects the CNS and how frequently it happens. Our review provides insight into the occurrence of mental disorders in Corona Virus Disease 2019 (COVID-19) patients. We also collected information about the biological basis of the susceptibility of brain cells to SARS-CoV-2 and its implication… Show more
“…In addition to these studies, all the others found in this review analyzed heterogenic populations of patients with COVID-19, from mild to severe. In this context, a recent editorial and a systematic review provided a detailed overview into the spectrum of mental disorders that can occur during the intermediate and long-term phases of COVID-19 in mild-to-critical patients (114,115). The most frequent neurological long-term symptoms in these patients were myalgia, arthralgia, sleeping troubles, and headache (46,50,61,116).…”
Section: Persistent Neurological Symptoms and Olfactory Dysfunctionsmentioning
Whilst the entire world is battling the second wave of COVID-19, a substantial proportion of patients who have suffered from the condition in the past months are reporting symptoms that last for months after recovery, i. e., long-term COVID-19 symptoms. We aimed to assess the current evidence on the long-term symptoms in COVID-19 patients. We did a systematic review on PubMed, Web of Science, EMBASE, and Google Scholar from database inception to February 15, 2021, for studies on long-term COVID-19 symptoms. We included all type of papers that reported at least one long-term COVID-19 symptom. We screened studies using a standardized data collection form and pooled data from published studies. Cohort cross-sectional, case-report, cases-series, case-control studies, and review were graded using specific quality assessment tools. Of 11,361 publications found following our initial search we assessed 218 full-text articles, of which 145 met all selection criteria. We found that 20.70% of reports on long-term COVID-19 symptoms were on abnormal lung functions, 24.13% on neurologic complaints and olfactory dysfunctions, and 55.17% on specific widespread symptoms, mainly chronic fatigue, and pain. Despite the relatively high heterogeneity of the reviewed studies, our findings highlighted that a noteworthy proportion of patients who have suffered from SARS-CoV-2 infection present a “post-COVID syndrome.” The multifaceted understanding of all aspects of the COVID-19 pandemic, including these long-term symptoms, will allow us to respond to all the global health challenges, thus paving the way to a stronger public health.
“…In addition to these studies, all the others found in this review analyzed heterogenic populations of patients with COVID-19, from mild to severe. In this context, a recent editorial and a systematic review provided a detailed overview into the spectrum of mental disorders that can occur during the intermediate and long-term phases of COVID-19 in mild-to-critical patients (114,115). The most frequent neurological long-term symptoms in these patients were myalgia, arthralgia, sleeping troubles, and headache (46,50,61,116).…”
Section: Persistent Neurological Symptoms and Olfactory Dysfunctionsmentioning
Whilst the entire world is battling the second wave of COVID-19, a substantial proportion of patients who have suffered from the condition in the past months are reporting symptoms that last for months after recovery, i. e., long-term COVID-19 symptoms. We aimed to assess the current evidence on the long-term symptoms in COVID-19 patients. We did a systematic review on PubMed, Web of Science, EMBASE, and Google Scholar from database inception to February 15, 2021, for studies on long-term COVID-19 symptoms. We included all type of papers that reported at least one long-term COVID-19 symptom. We screened studies using a standardized data collection form and pooled data from published studies. Cohort cross-sectional, case-report, cases-series, case-control studies, and review were graded using specific quality assessment tools. Of 11,361 publications found following our initial search we assessed 218 full-text articles, of which 145 met all selection criteria. We found that 20.70% of reports on long-term COVID-19 symptoms were on abnormal lung functions, 24.13% on neurologic complaints and olfactory dysfunctions, and 55.17% on specific widespread symptoms, mainly chronic fatigue, and pain. Despite the relatively high heterogeneity of the reviewed studies, our findings highlighted that a noteworthy proportion of patients who have suffered from SARS-CoV-2 infection present a “post-COVID syndrome.” The multifaceted understanding of all aspects of the COVID-19 pandemic, including these long-term symptoms, will allow us to respond to all the global health challenges, thus paving the way to a stronger public health.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.