Mental disorders as risk factors for suicidal behavior in young people: A meta-analysis and systematic review of longitudinal studies

Gili, Margalida; Castellví, Pere; Vives, Margalida; Torre‐Luque, Alejandro de la; Almenara, José; Blasco, María Jesús; Cebrià, Ana Isabel; Gabilondo, Andrea; Pérez-Ara, Ma. Ángeles; Miranda-Mendizábal, Andrea; Lagares‐Franco, Carolina; Parés‐Badell, Oleguer; Rodríguez, José Antonio Piqueras; Rodríguez-Jiménez, Tiscar; Marín, Jesús Rodríguez; Soto‐Sanz, Victoria; Alonso, Jordi; Roca, Miquel

doi:10.1016/j.jad.2018.10.115

Cited by 206 publications

(115 citation statements)

References 86 publications

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“…The results obtained in this meta‐analysis are consistent with those of Gili et al. 's meta‐analysis . Gili et al.…”

Section: Discussionsupporting

confidence: 91%

“…In Gili et al. 's meta‐analysis, the OR value (6.04; 95% CI) in studies involving affective disorders is similar to the value that we obtained in studies involving depression symptoms (OR = 6.58; 95% CI). In addition, the same meta‐analysis also found an association between having a disruptive disorder and performing a suicidal act (OR = 3.14; 95%CI), and our results show a similar OR (3.36; 95%CI) in the overall outcome of the studies that included having had some legal problem.…”

Section: Discussionsupporting

confidence: 85%

“…Gili et al. 's meta‐analysis results from the same wide‐ranging review as that in this study; however, the inclusion criteria differ, as studies evaluating mental disorders were included and those evaluating symptomatology without mental disorders were excluded. It is interesting that, in our case, although mental disorder was not studied and only symptoms were included, the results proved similar.…”

Section: Discussionmentioning

confidence: 99%

“…Mental disorders have been highlighted as some of the strongest predictors of suicidal behaviour among adolescents and youth. A recent meta‐analysis indicated having an affective disorder (OR = 6.04; 95% CI = 2.7–13.49) as the best predictor of suicide attempts, followed by anxiety disorders (OR = 3.5; 95% CI = 2.49–4.94), although in the latter case, statistical significance was not reached. Regarding behavioural disorders, this study indicates that disruptive disorders (OR = 3.14, 95% CI = 1.69–5.83) were significantly associated with suicidal acts.…”

Section: Introductionmentioning

confidence: 99%

“…There is abundant literature on risk factors associated with suicidal behaviour. These include prior presence of suicidal behaviour ; exposure to traumatic stressful events, such as abuse or victimization; the existence of some legal factors ; certain psychological factors, such as hopelessness, impulsiveness, or low self‐esteem ; the presence of somatic or disabling problems ; or previous history of mental disorders, especially emotional (depression and anxiety) and behavioural disorders .…”

Section: Introductionmentioning

confidence: 99%

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Internalizing and externalizing symptoms and suicidal behaviour in young people: a systematic review and meta‐analysis of longitudinal studies

Soto‐Sanz

Castellví

Rodríguez

et al. 2019

Acta Psychiatr Scand

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Internalizing and externalizing symptoms and suicidal behaviour in young people: a systematic review and meta-analysis of longitudinal studies.Objective: To assess internalizing and externalizing symptoms as risk factors for suicidal behaviour and suicide among adolescents and young adults. Method: We conducted a systematic review of articles published until January 2017. We identified 26 883 potential papers; 1701 full-text articles were assessed for eligibility, of which 1479 were excluded because of methodological reasons. Diverse meta-analyses were performed for each group of symptoms. Odds ratios (ORs) and 95% confidence intervals (95% CI) or beta coefficients for categorical variables, and effect size (ES) were calculated for continuous variables. Results: Finally, 41 studies were included, involving participants aged 12-26 years for a systematic review, and 24 articles were included for meta-analysis. The meta-analysis showed that youths with any internalizing (ES = 0.93) or externalizing symptoms (ES = 0.76 and OR = 2.59) were more likely to attempt suicide in future. This effect was also seen in depression symptoms (OR = 6.58 and ES = 1.00), legal problems (OR = 3.36), and anxiety (ES = 0.65). Conclusion: Reported internalizing and externalizing symptoms are predictors of suicide behaviour in young people; therefore, the detection and management of these symptoms in young populations could be a crucial strategy for preventing suicidality in this group.

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“…The results obtained in this meta‐analysis are consistent with those of Gili et al. 's meta‐analysis . Gili et al.…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Internalizing and externalizing symptoms and suicidal behaviour in young people: a systematic review and meta‐analysis of longitudinal studies

Soto‐Sanz

Castellví

Rodríguez

et al. 2019

Acta Psychiatr Scand

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Predictors, Moderators, and Mediators Associated With Treatment Outcome in Randomized Clinical Trials Among Adolescents With Depression

et al. 2022

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IMPORTANCEThe application of precision medicine principles for the treatment of depressive disorders in adolescents requires an examination of the variables associated with depression outcomes in randomized clinical trials (RCTs). OBJECTIVE To describe predictors, moderators, and mediators associated with outcomes in RCTs for the treatment of depressive disorders in adolescents. EVIDENCE REVIEWA scoping review of RCTs for the treatment of depression in adolescents was conducted. Databases searched included MEDLINE, Embase, APA PsycInfo, and CINAHL. Included publications tested predictors, moderators, and/or mediators associated with depression symptom outcomes (eg, symptom reduction, response, remission) in RCTs pertaining to the treatment of adolescents, ages 13 to 17 years. Predictors were defined as variables that were associated with depression outcomes, independent of treatment group. Moderators were defined as baseline variables that were associated with differential outcomes between treatment groups. Mediators were defined by a formal mediation analysis. In duplicate, variables were extracted and coded with respect to analysis type (univariable or multivariable), statistical significance, direction of effect size, reporting of a priori hypotheses, and adjustment for multiple comparisons. Aggregated results were summarized by variable domain and RCT sample.FINDINGS Eighty-one articles reporting on variables associated with outcomes across 33 RCTs were identified, including studies of biological (10 RCTs), psychosocial (18 RCTs), and combined (4 RCTs) treatments as well as a service delivery model (1 RCT). Fifty-three variable domains were tested as baseline predictors of depression outcome, 41 as moderators, 19 as postbaseline predictors, and 5 as mediators. Variable domains that were reported as significant in at least 3 RCTs included age, sex/gender, baseline depression severity, early response to treatment, sleep changes, parent-child conflict, overall psychopathology, suicidal ideation, hopelessness, functional impairment, attendance at therapy sessions, and history of trauma. Two publications reported a priori hypotheses and adjustment for multiple comparisons, both finding that baseline depression severity and family conflict were associated with poorer outcomes. CONCLUSIONS AND RELEVANCEThis review identified commonly researched variables requiring more scrutiny as well as underresearched variables to inform future study designs. Further efforts to discover predictors, moderators, and mediators associated with treatment response have great potential to optimize care for adolescents with depression.

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Familial Aggregation and Coaggregation of Suicide Attempts and Comorbid Mental Disorders in Adults

et al. 2019

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IMPORTANCE Clarification of the joint influence of familial patterns of suicide attempts and comorbid mental disorders can enhance the understanding and prevention of suicide attempts. OBJECTIVE To investigate the familial patterns of suicide attempts and comorbid mental disorders and their associations in a 2-site family study of mood and anxiety disorders. DESIGN, SETTING, AND PARTICIPANTS Data were obtained from 2 parallel community-based family studies conducted in the United States (National Institute of Mental Health [NIMH] study) and in Lausanne, Switzerland (PsyCoLaus study), on the comorbidity of mood and anxiety disorders. The study sample comprised 1119 adult probands and 5355 first-degree relatives. Data were collected and analyzed from October 2004 to December 2016. MAIN OUTCOMES AND MEASURES Lifetime suicide attempt and mental disorders in first-degree relatives, obtained through direct interviews or family history reports. RESULTS The study included 1119 adult probands (675 female [60.3%] and a mean [SD] age of 50 [12.0] years) and 5355 first-degree relatives (2752 female [51.4%] and a mean [SD] age of 52 [1.5] years). Of these participants, 90 (8.0%) of 1119 probands and 199 (3.7%) of 5355 relatives had a lifetime history of suicide attempt. Those with such a history had higher rates of all mental disorders, a greater number of disorders, and statistically significantly poorer current and lifetime global functioning. After adjustment for age and sex, a statistically significant association between suicide attempts in probands and in relatives was found at the NIMH site (OR, 2.6; 95% CI, 1.5-4.7), at the Lausanne site (OR, 3.1; 95% CI, 1.6-6.0), and in the combined data (OR, 2.9; 95% CI, 1.9-4.5). All mood disorder subtypes and substance use disorders were statistically significantly associated with suicide attempts. The familial association between lifetime suicide attempts in probands and relatives was not statistically significant for the combined sample (OR, 1.6; 95% CI, 1.0-2.7) after adjustment for comorbid conditions in probands and relatives. Social anxiety disorder in probands was associated with suicide attempts in relatives (OR, 2.4; 95% CI, 1.7-3.5) after controlling for comorbid mood, anxiety, and substance use disorders. CONCLUSIONS AND RELEVANCE Familiality of suicide attempts appears to be explained by a history of mental disorders among those with suicide attempts; the novel finding of a common familial diathesis for suicide attempts and social anxiety, particularly in combination with mood disorders, has heuristic value for future research and may be a risk marker that can inform prevention efforts.

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Mental disorders as risk factors for suicidal behavior in young people: A meta-analysis and systematic review of longitudinal studies

Cited by 206 publications

References 86 publications

Internalizing and externalizing symptoms and suicidal behaviour in young people: a systematic review and meta‐analysis of longitudinal studies

Internalizing and externalizing symptoms and suicidal behaviour in young people: a systematic review and meta‐analysis of longitudinal studies

Predictors, Moderators, and Mediators Associated With Treatment Outcome in Randomized Clinical Trials Among Adolescents With Depression

Familial Aggregation and Coaggregation of Suicide Attempts and Comorbid Mental Disorders in Adults

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