Mental Disorders and Female Infertility

Schweiger, Ulrich; Schweiger, Julietta Ursula; Schweiger, Janina I.

doi:10.31296/aop.v2i6.73

Cited by 14 publications

(9 citation statements)

References 59 publications

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“…Infertility diagnosis and the subsequent treatment process usually impose excruciating stress on couples. Several studies have reported that couples with infertility are prone to experiencing depression (6), anxiety (7), sexual intercourse problems, marital problem (8,9), decrease in selfconfidence (10), and low levels of psychological well-being (11,12) and quality of life (13).…”

Section: Introductionmentioning

confidence: 99%

Psychosocial Consequences of Female Infertility in Iran: A Meta-Analysis

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Psychosocial Consequences of Female Infertility in Iran: A Meta-Analysis

et al. 2020

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“…In the world, ;5-10% of women at the reproductive age face some kind of infertility problem. Ovarian disorders are responsible for more than half of female infertility (1,2). Ovarian disorders include major reproductive diseases in human such as polycystic ovary syndrome (3) and ovulation with luteal insufficiency (4).…”

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confidence: 99%

Exogenous adrenocorticotropic hormone affects genome‐wide DNA methylation and transcriptome of corpus luteum in sows

Zhao

Wei

et al. 2018

FASEB j.

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Stress is known to cause corpus luteum (CL) dysfunction, and stress hormones play a critical role in this process. However, the mechanism remains unclear. In this study, weaned sows were injected with synthetic adrenocorticotropic hormone (ACTH) for 7 d; whole‐genome bisulfite sequencing (WGBS) and RNA sequencing was used respectively to investigate the systematic association between ACTH administration and DNA methylation in CL and its relationship to gene expression. Results showed that ACTH treatment significantly increased the concentrations of Cortisol (P < 0.05). The genome‐wide DNA methylation maps of CL were provided, and the global analysis showed the difference between the 2 groups exists in the chromosomes and feature regions of the genome. A total of 88,559 DMRs were identified and the most DMR‐related genes were gathered in terms of metabolic biologic processes, and some DMR‐related genes were involved in cellular differentiation. Nine differentially expressed genes were screened out of coexpressed genes and 4 DMR‐associated genes that were also differentially expressed (P < 0.05). In summary, our study firstly provides insight into the regulation of ACTH administration on genomic DNA methylation and gene expression in CL. We revealed a remarkable alteration of DNA methylation in CL caused by ACTH treatment, and identified 4 DMR‐related genes that may be involved in the CL function under stress conditions.—Zhao, F., Wu, W., Wei, Q., Shen, M., Li, B., Jiang, Y., Liu, K., Liu, H. Exogenous adrenocorticotropic hormone affects genome‐wide DNA methylation and transcriptome of corpus luteum in sows. FASEB J. 33, 3264–3278 (2019). http://www.fasebj.org

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“…7 Depression in women with infertility may affect treatment seeking, compliance to follow-up as well as hope for the future. 8 A review of the research literature from Pakistan shows that Shoaib et al (2004) looked at the mental health of females with infertility and found psychiatric morbidity in 76% of their study sample of which depression was the most common diagnosis (46.03%). 9 A similar study conducted by Verma India found 56.4% (79/140) of the infertile females to be suffering from depression.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and determinants of depression in females with primary infertility.

Fatima

Choudhary

Haider

et al. 2021

TPMJ

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Objective: This study was designed to evaluate the prevalence of depression in females with primary infertility at a tertiary care hospital in Rawalpindi and identify the factors associated with the condition. Study Design: Descriptive Cross-sectional study. Setting: Infertility Clinic of the Department of Obstetrics and Gyanecology, Benazir Bhutto Hospital, Rawalpindi. Period: February to August 2016. Material & Methods: Females between the ages of 18 and 40 years with primary infertility were included in the study. The presence and severity of depressive symptoms were assessed using the Hamilton Rating Scale for Depression (HAM-D). Socio-demographic details and clinical information was collected on a pre-designed proforma. Results: A total of 102 females were included in the study. The mean age of the patients was 31 years with a STD of ± 4.3 years. 78.4% (n=80) patients were suffering from depression on the basis of HAM-D scores. 18 (17.6%) had mild depression, 34 (33.3%) had moderate depression, 20 (19.6%) had severe depression and 8 (7.8%) patients had very severe depression. An analysis of the socio-demographic factors showed that a majority of the females were educated, housewives and living in extended families. The frequency of depression was significantly associated with a low monthly household income (p=0.046). Conclusion: A high proportion of females with primary infertility suffer from depression. Screening for psychiatric illnesses should be part of the standard evaluation of these patients. Early detection and timely psychological intervention can lead to a significant reduction in long-term morbidity.

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Mental Disorders and Female Infertility

Cited by 14 publications

References 59 publications

Psychosocial Consequences of Female Infertility in Iran: A Meta-Analysis

Psychosocial Consequences of Female Infertility in Iran: A Meta-Analysis

Exogenous adrenocorticotropic hormone affects genome‐wide DNA methylation and transcriptome of corpus luteum in sows

Prevalence and determinants of depression in females with primary infertility.

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