Mental Disorders and Asthma in the Community

Goodwin, Renée D.; Jacobi, Frank; Thefeld, Wolfgang

doi:10.1001/archpsyc.60.11.1125

Cited by 317 publications

(242 citation statements)

References 40 publications

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“…Apart from these spurious associations, we would like to highlight some common chronic medical illnesses and their link with psychiatric disorders found in our two-by-two comparisons of disorders. The association of asthma with anxiety, mood, substance abuse disorders, and dissociative and somatoform disorders is consistent with previous studies of population-based samples (26). Inner-city patients of low socioeconomic status with asthma may be at a particular risk for mental disorders.…”

Section: Variablesupporting

confidence: 90%

Clustering of psychiatric and somatic illnesses in the general population: multimorbidity and socioeconomic correlates

Andrade

Viana

Andreoni

et al. 2010

Braz J Med Biol Res

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The distribution of psychiatric disorders and of chronic medical illnesses was studied in a population-based sample to determine whether these conditions co-occur in the same individual. A representative sample (N = 1464) of adults living in households was assessed by the Composite International Diagnostic Interview, version 1.1, as part of the São Paulo Epidemiologic Catchment Area Study. The association of sociodemographic variables and psychological symptoms regarding medical illness multimorbidity (8 lifetime somatic conditions) and psychiatric multimorbidity (15 lifetime psychiatric disorders) was determined by negative binomial regression. A total of 1785 chronic medical conditions and 1163 psychiatric conditions were detected in the population concentrated in 34.1 and 20% of respondents, respectively. Subjects reporting more psychiatric disorders had more medical illnesses. Characteristics such as age range (35-59 years, risk ratio (RR) = 1.3, and more than 60 years, RR = 1.7), being separated (RR = 1.2), being a student (protective effect, RR = 0.7), being of low educational level (RR = 1.2) and being psychologically distressed (RR = 1.1) were determinants of medical conditions. Age (35-59 years, RR = 1.2, and more than 60 years, RR = 0.5), being retired (RR = 2.5), and being psychologically distressed (females, RR = 1.5, and males, RR = 1.4) were determinants of psychiatric disorders. In conclusion, psychological distress and some sociodemographic features such as age, marital status, occupational status, educational level, and gender are associated with psychiatric and medical multimorbidity. The distribution of both types of morbidity suggests the need of integrating mental health into general clinical settings.

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Section: Variablesupporting

confidence: 90%

Clustering of psychiatric and somatic illnesses in the general population: multimorbidity and socioeconomic correlates

Andrade

Viana

Andreoni

et al. 2010

Braz J Med Biol Res

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“…The lack of evidence for an association between atopic illness and hypomanic symptoms is surprising given a number of cross-sectional studies (Goodwin et al 2003;Beyer et al 2005;Jerrell et al 2010) and longitudinal studies (Liang & Chikritzhs, 2013;Chen et al 2014;Lin et al 2014) have reported an association between asthma and bipolar disorder. This may be because previous studies have examined the severe end of the bipolar spectrum (hospitalization for bipolar disorder) and this association may not hold when our broad definition of hypomania is used.…”

Section: Discussionmentioning

confidence: 99%

Childhood interleukin-6, C-reactive protein and atopic disorders as risk factors for hypomanic symptoms in young adulthood: a longitudinal birth cohort study

Hayes¹,

Khandaker²,

Anderson³

et al. 2017

Psychol. Med.

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Background. There are no existing longitudinal studies of inflammatory markers and atopic disorders in childhood and risk of hypomanic symptoms in adulthood. This study examined if childhood: (1) serum interleukin-6 (IL-6) and C-reactive protein (CRP); and (2) asthma and/or eczema are associated with features of hypomania in young adulthood.Method. Participants in the Avon Longitudinal Study of Parents and Children, a prospective general population UK birth cohort, had non-fasting blood samples for IL-6 and CRP measurement at the age of 9 years (n = 4645), and parents answered a question about doctor-diagnosed atopic illness before the age of 10 years (n = 7809). These participants completed the Hypomania Checklist at age 22 years (n = 3361).Results. After adjusting for age, sex, ethnicity, socio-economic status, past psychological and behavioural problems, body mass index and maternal postnatal depression, participants in the top third of IL-6 values at 9 years, compared with the bottom third, had an increased risk of hypomanic symptoms by age 22 years [adjusted odds ratio 1.77, 95% confidence interval (CI) 1.10-2.85, p < 0.001]. Higher IL-6 levels in childhood were associated with adult hypomania features in a dose-response fashion. After further adjustment for depression at the age of 18 years this association remained (adjusted odds ratio 1.70, 95% CI 1.03-2.81, p = 0.038). There was no evidence of an association of hypomanic symptoms with CRP levels, asthma or eczema in childhood.Conclusions. Higher levels of systemic inflammatory marker IL-6 in childhood were associated with hypomanic symptoms in young adulthood, suggesting that inflammation may play a role in the pathophysiology of mania. Inflammatory pathways may be suitable targets for the prevention and intervention for bipolar disorder.

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“…[4,8,9,28] A recent epidemiologic study in youth 9 to 17 years of age reported that youth with a history of asthma were more likely to have any anxiety disorder, simple phobia, separation anxiety and overanxious disorder compared to controls.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of DSM-IV Anxiety and Depressive Disorders in Youth with Asthma Compared with Controls

Katon

Lozano

Russo

et al. 2007

Journal of Adolescent Health

224

158

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Purpose-To determine the prevalence of anxiety and depressive disorders in youth with asthma compared to a control sample of youth and to determine the sociodemographic and clinical characteristics associated with having ≥1 anxiety/depressive disorders among youth with asthma.Methods-A telephone interview was offered to all youth aged 11 to 17 with asthma (N=781) and a random sample of similar aged controls (N=598) enrolled in a Health Maintenance Organization (HMO). The C-DISC-4.0 was used to diagnose anxiety and depressive disorders and reliable and valid questionnaires were used to assess severity of anxiety and depressive symptoms. Automated diagnostic, pharmacy and health utilization data were used to measure asthma treatment intensity, asthma severity and non-asthmatic medical comorbidity. One parent was interviewed to assess sociodemographic variables, child/adolescent psychiatric symptoms and to confirm the asthma diagnosis.Results-16.3% of youth with asthma compared to 8.6% of youth without asthma met DSM-IV criteria for ≥1 anxiety and depressive disorders (OR = 1.92, 95% CI 1.13-3.28). Independent factors associated with a significantly higher likelihood of meeting criteria for ≥1 anxiety or depressive disorders included female gender [OR = 1.96 (95% CI 1.27, 3.03)], living in a single parent household, [OR = 1.96 (95% CI 1.26, 3.07)], more parent-reported externalizing behaviors [OR = 1.03 (95% CI 1.01, 1.05)], more recent diagnosis of asthma [OR = 0.94 (95% CI 0.89, 0.98)], and more impairment on the asthma physical health scale [OR = 0.95 (95% CI 0.94, 0.96)].Conclusions-Youth with asthma have an almost two-fold higher prevalence of comorbid DSM-IV anxiety and depressive disorders compared to control youth. Clinical factors associated with meeting criteria for ≥1 anxiety and depressive included more recent asthma diagnosis, more impairment on the asthma physical health scale and increased externalizing behaviors. Medicine, 1959 NE Pacific St., Seattle, WA 98195-6560, PH: 206-543-7177, Fax: 206-221-5414, E-Mail: wkaton@u.washington.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Cross-sectional studies have repeatedly found an increased prevalence of panic disorder among youth with asthma. [1][2][3][4][5] A large family history study also recently reported that first degree relatives of patients with panic disorder had a significantly higher prevalence of asthma and chronic obstructive lung disease compared to a control group without panic disorder. NIH Public Access[6] Recent research suggests that youth with asthma also have a high rate of ot...

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Mental Disorders and Asthma in the Community

Cited by 317 publications

References 40 publications

Clustering of psychiatric and somatic illnesses in the general population: multimorbidity and socioeconomic correlates

Clustering of psychiatric and somatic illnesses in the general population: multimorbidity and socioeconomic correlates

Childhood interleukin-6, C-reactive protein and atopic disorders as risk factors for hypomanic symptoms in young adulthood: a longitudinal birth cohort study

The Prevalence of DSM-IV Anxiety and Depressive Disorders in Youth with Asthma Compared with Controls

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