Menstrual pattern and ovarian function in women with hyperprolactinemia

Abstract

Prolactin (PRL) and progesterone were systematically measured in all women presenting with amenorrhea, oligomenorrhea or galactorrhea at the Infertility Clinic of the Department of Obstetrics and Gynecology, State University of Campinas, Brazil, during a period of 34 months. The same hormonal assays were done to all infertile patients presenting for the first time during the last 6 months of the same period, for a total of 190 subjects. Fifty-five patients with amenorrhea, 38 with oligomenorrhea and 97 with normal cycles, 20 of whom had galactorrhea, were included in the study. Fifty-five percent of amenorrheic patients, 37% of oligomenorrheic and 9% of those with normal menses had elevated PRL. The mean PRL was higher the greater the menstrual disturbance but was not influenced by presence or absence of galactorrhea. Short luteal phase was the ovarian function condition most frequently associated with high PRL among women with normal menses.

Prevalence of conditions causing chronic anovulation and the proposed algorithm for anovulation evaluation

“…From this study, prolactin and thyroid disorders were the second and fourth most common causes of anovulation. So, the tests for these two disorders are essential in the assessment of women with anovulation . The ADD and testosterone tests might not be available in every hospital, especially in primary health‐care settings.…”

“…So, the tests for these two disorders are essential in the assessment of women with anovulation. 10,11 The ADD and testosterone tests might not be available in every hospital, especially in primary health-care settings. Thus, TSH and PRL assay will probably need to be the first step of anovulation evaluation in these circumstances, followed by ADD and testosterone level assessment as the second steps.…”

Proton pump inhibitors therapy and risk of hyperprolactinemia with associated sexual disorders

“…Primary amenorrhea is the first symptom in the prepubertal patients. Galactorrhea may be seen either spontaneously or after nipple stimulation; however, many premenopausal women with high serum prolactin do not exhibit this phenomenon (Bahamondes et al 1985;Sartorio et al 2000;Verhelst and Abs 2003;Majumdar and Mangal 2013).…”

An interesting hormon and interesting disease: hyperprolactinemia and prolactinoma

“…Sekonder amenore ise %30 sıklığındadır [50]. İnfertilite nedeni ile başvuran hiperprolaktinemik hastaların %55'inde amenore ve %37'sinde oligoamenore saptanırken %9'unun ise normal menstruasyon gördüğü tespit edilmiştir [51].…”