Menstrual Migraine and Other Hormonal Aspects of Migraine

Edelson, Richard N.

doi:10.1111/j.1526-4610.1985.hed2507376.x

Cited by 89 publications

(49 citation statements)

References 7 publications

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“…A number of findings provide support for a relationship between hormonal variations and migraine. These include evidence indicating that many women with migraine report worsening of their headaches around the time of menstruation [Edelson, 1985;Greene, 1967;Lance and Anthony, 1966]. In fact, menstrual migraine (i.e., 90% of attacks of MO occur in association with menstruation) is experienced by 24-25% of females with MO [Rasmussen, 1993;Russell et al, 1996].…”

Section: Genetic Influence and Sex-limitationmentioning

confidence: 96%

Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities

Nyholt

Gillespie

Heath

et al. 2004

Genetic Epidemiology

114

121

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Latent class and genetic analyses were used to identify subgroups of migraine sufferers in a community sample of 6,265 Australian twins (55% female) aged 25-36 who had completed an interview based on International Headache Society (IHS) criteria. Consistent with prevalence rates from other population-based studies, 703 (20%) female and 250 (9%) male twins satisfied the IHS criteria for migraine without aura (MO), and of these, 432 (13%) female and 166 (6%) male twins satisfied the criteria for migraine with aura (MA) as indicated by visual symptoms. Latent class analysis (LCA) of IHS symptoms identified three major symptomatic classes, representing 1) a mild form of recurrent nonmigrainous headache, 2) a moderately severe form of migraine, typically without visual aura symptoms (although 40% of individuals in this class were positive for aura), and 3) a severe form of migraine typically with visual aura symptoms (although 24% of individuals were negative for aura). Using the LCA classification, many more individuals were considered affected to some degree than when using IHS criteria (35% vs. 13%). Furthermore, genetic model fitting indicated a greater genetic contribution to migraine using the LCA classification (heritability, h(2)=0.40; 95% CI, 0.29-0.46) compared with the IHS classification (h(2)=0.36; 95% CI, 0.22-0.42). Exploratory latent class modeling, fitting up to 10 classes, did not identify classes corresponding to either the IHS MO or MA classification. Our data indicate the existence of a continuum of severity, with MA more severe but not etiologically distinct from MO. In searching for predisposing genes, we should therefore expect to find some genes that may underlie all major recurrent headache subtypes, with modifying genetic or environmental factors that may lead to differential expression of the liability for migraine.

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Section: Genetic Influence and Sex-limitationmentioning

confidence: 96%

Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities

Nyholt

Gillespie

Heath

et al. 2004

Genetic Epidemiology

114

121

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“…Dentre as cefaléias primárias, a influência do ciclo menstrual permanece mais bem determinada e estabelecida para a migrânea [4][5][6] . Estudos clínicos mostram que, em mulheres migranosas, a freqüência de migrânea associada à menstruação chega a 60% -70% 5,7 . A classificação das cefaléias, em particular da migrâ-nea, relacionadas ao ciclo menstrual, permanece conceitualmente problemática.…”

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Cefaléia menstrual: estudo semiológico de 100 casos

Miziara

Bigal

Bordini

et al. 2003

Arq. Neuro-Psiquiatr.

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RESUMO -Ao redor de 60% das mulheres com migrânea associam o período menstrual com a desencadear das crises. Para cefaléias não migranosas, essa relação é menos evidente. O objetivo desse estudo é apresentar a caracterização clínica da cefaléia menstrual. Cefaléia menstrual foi conceituada, em nosso estudo, como aquela cefaléia compreendida entre dois dias antes do primeiro dia da menstruação e o último dia da mesma. As variáveis avaliadas foram: intensidade, características e localização da dor e dos sintomas associados. Foi analisada a cefaléia de 100 mulheres (154 períodos menstruais), com idades entre 20 e 45 anos. A maior parte foi classificada como migrânea sem aura; a intensidade era severa no primeiro dia de dor, com redução gradativa nos dias subseqüentes; as cefaléias eram predominantemente de qualidade latejante, referidas como unilaterais em algum momento do ciclo menstrual; a duração foi maior que a tradicionalmente referida na literatura. A maior parte se iniciou dois dias antes do início do ciclo menstrual. Náuseas e/ou vômitos foram os sintomas associados mais freqüentes. Foram diagnosticados 9 casos de cefaléia do tipo tensional, 2 casos de cefaléia cervicogênica e 1 caso de cefaléia em pontadas.PALAVRAS-CHAVE: cefaléia menstrual, caracterização clínica, migrânea menstrual. Menstrual headache: semiological study in 100 casesABSTRACT -About 60% of women with migraine associate their headache attacks to the menstrual period. Regarding the non-migrainous headaches, this relationship is not so clear. The aim of this study is to present a clinical evaluation of menstrual headaches. Menstrual headache in our study was defined as the headache that begins in the interval of time from 2 days before menstruation until the last day of the menstrual period. The analyzed parameters were: intensity, character and localization of the pain, and associated symptoms. The headaches of 100 women (154 periods) whose ages ranged from 20 to 45 years were analyzed. Most headaches were classified as migraine without aura; the headaches had strong intensity in the first day of pain and reduced gradually until the last day of pain. The headaches were mostly of throbbing character and, in some moment of the menstrual period, referred as unilateral; the duration of these headaches was of longer duration than the migraine attacks reported in medical literature. Most part of the headaches began two days before the first day of the menstrual flow. Nauseas and/or vomiting were the most frequent associated symptoms. Finally, we found, among the menstrual headaches, 9 cases of tension type headache, 2 cases of cervicogenic headache and 1 case of stabbing headache.KEY WORDS: menstrual headache, clinical description, menstrual migraine. A associação entre cefaléia e taxas de hormônios sexuais na mulher é bem conhecida 1-3 . A prevalência de cefaléia associada à menstruação depende da definição utilizada e da população estudada. Dentre as cefaléias primárias, a influência do ciclo menstrual permanece mais bem determinada e estabelec...

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“…Ergotamine derivatives may be used for short-term prophylaxis but must be used only during the vulnerable period to avoid ergot dependence [24]. Effective regimens include ergotamine tartrate one tablet twice daily or half suppository every night taken over the vulnerable perimenstrual time period.…”

Section: Short-term Preventionmentioning

confidence: 99%

Preventative treatment of menstrual migraine

Lay

Broner²

2007

Curr Pain Headache Rep

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More than 20 million US women suffer with migraine, two thirds of whom experience menstrually related migraine. Estrogen plays an important role in triggering migraine, and given the numerous hormonal fluctuations throughout a woman's lifetime, there are many opportunities for a hormonal impact. Accurate diagnosis is key to initiating effective treatment, and when acute therapy fails, the unique predictability of menstrual migraine lends itself to preventative treatment.

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Menstrual Migraine and Other Hormonal Aspects of Migraine

Cited by 89 publications

References 7 publications

Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities

Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities

Cefaléia menstrual: estudo semiológico de 100 casos

Preventative treatment of menstrual migraine

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