Menstrual irregularity in the first postmenarchal years: an early clinical sign of polycystic ovary syndrome in adolescence

Avvad, Cristina Kayat; Holeuwerger, R.; Silva, V. C. G.; Bordallo, Maria Alice Neves; Breitenbach, M. M. D.

doi:10.1080/713602836

Cited by 12 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two thirds of adolescents whose oligomenorrhea persisted for 2 or more years still have oligomenorrhea 10 years later [39, 40]. Avvad et al [41] reported that menstrual irregularity within the first postmenarchal years can be an early clinical sign of PCOS.…”

Section: Discussionmentioning

confidence: 99%

Determinants of ApoB, ApoA1, and the ApoB/ApoA1 ratio in healthy schoolgirls, prospectively studied from mean ages 10 to 19 years: the Cincinnati National Growth and Health Study

et al. 2012

View full text Add to dashboard Cite

The objectives were to prospectively assess determinants of apolipoproteins B (ApoB), A1 (ApoA1), and the ApoB/ApoA1 ratio in 797 healthy black and white schoolgirls from mean ages 10 to 19. There was prospective 9-year follow-up, with measures of ApoB at mean ages 10, 12, 14,16 and 19, ApoA1at mean ages 12, 14, 16, and 19, and assessment of annual reports of delayed menstrual cyclicity (≥42 days) from ages 14 to 19. Studies of 402 black and 395 white healthy schoolgirls were done in public and private schools, in urban and suburban Cincinnati. Black girls had lower ApoB, higher ApoA1, and lower ApoB/ApoA1. SHBG at age 14 in white and black girls was inversely correlated with the ApoB/ApoA1. At age 19, ≥3 annual reports of menstrual delay ≥42 days and metabolic syndrome were associated with higher ApoB and a higher ApoB/ApoA1 ratio. From ages 14 to 19, BMI and TG were independently positively associated with ApoB. Menstrual cyclicity ≥42 days, metabolic syndrome, BMI, and TG were independently positively associated with ApoB/ApoA1 ratios, while black race was negatively associated. The atherogenic ApoB/ApoA1 ratio from ages 14 to 19 is lower in black girls, and positively associated with hyperandrogenism, menstrual cyclicity ≥42 days, BMI, TG, and the metabolic syndrome, facilitating an adolescent approach to primary prevention of cardiovascular disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Determinants of ApoB, ApoA1, and the ApoB/ApoA1 ratio in healthy schoolgirls, prospectively studied from mean ages 10 to 19 years: the Cincinnati National Growth and Health Study

et al. 2012

View full text Add to dashboard Cite

show abstract

“…According to recent studies, menstrual irregularities within the first years after menarche can be considered as an early clinical sign of PCOS [14]. Based on another study [12], the occurrence of PCOS increased significantly with irregularities in the menstrual cycle pattern.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Polycystic Ovary Syndrome in Girls Aged 14–18 Years in Isfahan, Iran

et al. 2004

View full text Add to dashboard Cite

Objective: To determine the prevalence of clinical polycystic ovary syndrome (PCOS) in 14- to 18-year-old high school girls in Isfahan, Iran. Methods: In this cross-sectional study, 1,000 high school girls (14–18 years old) were selected by multi-stage random sampling from different high schools in Isfahan. Following physical examination, a single physician recorded the presence of hirsutism, severe acne, androgenic alopecia, menstrual dysfunction and obesity using a validated questionnaire. Clinical PCOS was diagnosed if menstrual dysfunction and clinical hyperandrogenism were detected. Results: Clinical PCOS was present in 30 (3%), hirsutism in 60 (6%), menstrual dysfunction in 74 (7.4%) and severe acne in 47 (4.7%) of the population studied. Conclusion: The prevalence of clinical PCOS in our study population was similar to those of other studies; however, the prevalence could have been higher with hormonal assessment.

show abstract

“…65 To some extent this is because the adolescent ovary may normally have a multifollicular appearance, 58,71 but many meet current polycystic follicle count criteria. 52,64,66–68 Furthermore, several studies indicate that ovarian volume during adolescence is larger than that of the normal adult: for example, the median for the normal upper limit of mean ovarian volume during adolescence according to studies to date approximates 12 cc (Table 5). 52,56,66–70,72,73 Thus, application of adult criteria for PCOM to adolescents seems very problematic.…”

Section: Discussionmentioning

confidence: 99%

The Polycystic Ovary Morphology-Polycystic Ovary Syndrome Spectrum

Rosenfield

2015

Journal of Pediatric and Adolescent Gynecology

View full text Add to dashboard Cite

Background Polycystic ovary syndrome (PCOS) is the most common cause of chronic hyperandrogenic anovulation. Two-thirds of PCOS patients have functionally typical PCOS, with typical functional ovarian hyperandrogenism manifest as 17-hydroxyprogesterone hyper-responsiveness to gonadotropin stimulation. Most, but not all, of the remainder have atypical functional ovarian hyperandrogenism. Many asymptomatic volunteers with polycystic ovary morphology (PCOM) have similar abnormalities. Objective The objective of this paper is to review the relationship of biochemical ovarian function to the clinical spectrum observed in PCOS and in normal volunteers with PCOM. Findings Adolescents and adults with PCOS are similar clinically and biochemically. Ninety-five percent of functionally typical PCOS have classic PCOS, ie, hyperandrogenic anovulation with PCOM. In addition to having more severe hyperandrogenism and a greater prevalence of PCOM than other PCOS, they have a significantly greater prevalence of glucose intolerance although insulin resistance is similarly reduced. Half of normal-variant PCOM have PCOS-related steroidogenic dysfunction, which suggests a PCOS carrier state. Conclusions There is a spectrum of ovarian androgenic dysfunction that ranges from subclinical hyperandrogenemia in some normal-variant PCOM to severe ovarian hyperandrogenism in most classic PCOS. A minority of mild PCOS cases do not fall on this spectrum of ovarian androgenic dysfunction, but rather seem to have obesity as the basis of their hyperandrogenism, or, less often, isolated adrenal androgenic dysfunction. Half of normal-variant PCOM also do not fall on the PCOS spectrum, and some of these seem to have excessive folliculogenesis as a variant that may confer mild prolongation of the reproductive lifespan. Improved understanding of PCOM in young women is needed.

show abstract

Menstrual irregularity in the first postmenarchal years: an early clinical sign of polycystic ovary syndrome in adolescence

Cited by 12 publications

References 0 publications

Determinants of ApoB, ApoA1, and the ApoB/ApoA1 ratio in healthy schoolgirls, prospectively studied from mean ages 10 to 19 years: the Cincinnati National Growth and Health Study

Determinants of ApoB, ApoA1, and the ApoB/ApoA1 ratio in healthy schoolgirls, prospectively studied from mean ages 10 to 19 years: the Cincinnati National Growth and Health Study

Prevalence of Polycystic Ovary Syndrome in Girls Aged 14–18 Years in Isfahan, Iran

The Polycystic Ovary Morphology-Polycystic Ovary Syndrome Spectrum

Contact Info

Product

Resources

About