Menstrual Cycle Exhibits No Effect on Postprandial Lipemia

Wendler, D; Michel, Erik; Kastner, Petr; Fw, Schmahl

doi:10.1055/s-2007-1003394

Cited by 13 publications

(9 citation statements)

References 2 publications

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“…vegetable lasagne [5.7 g fat; 9.7 g carbohydrate; 3.9 g protein (100 g) )1 ], followed by vanilla flavoured yoghurt with strawberries [3.2 g fat; 16.1 g carbohydrate; 4.1 g protein (100 g) )1 ].This meal was provided ad libitum for the first trial and the consumption was replicated for the second trial. No attempt was made to control for the phase of the menstrual cycle in this study but other groups have reported that there is no significant effect of menstrual phase on postprandial lipaemia (Wendler et al 1992) or adipose tissue LPL activity (Rebuffe-Scrive et al 1985).…”

Section: Standardisation Prior To Both Experimentsmentioning

confidence: 93%

Effects of a brisk walk on lipoprotein lipase activity and plasma triglyceride concentrations in the fasted and postprandial states

et al. 2003

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This study aimed to determine whether changes in plasma heparin-releasable lipoprotein lipase (LPL) activity following a brisk walk were associated with decreases in fasting and/or postprandial triglyceride (TG) concentrations. Two groups of pre-menopausal women participated. In one group (fasting study group, n=10), TG concentrations and post-heparin plasma LPL activity were measured in the fasted state on two occasions: approximately 18 h after a 2-h treadmill walk at 50% maximal oxygen uptake (exercise trial); and after a day of no exercise (control trial). The other group (postprandial study group, n=9) undertook two oral fat tolerance tests (blood samples taken fasting and for 6 h after a high-fat meal), with plasma LPL activity measured 6 h after meal ingestion. Pre-conditions were the same as for the fasting study group (i.e. control and prior exercise). Prior exercise reduced fasting TG concentrations by 23 (7)% (fasting study group) [mean (SEM)] and by 18 (9)% (postprandial study group) (both P<0.05), and the postprandial TG response by 23 (6)% (postprandial study group) (P<0.01). Plasma LPL activity was not significantly increased by exercise in either the fasting or postprandial study groups. However, exercise-induced changes in both fasting and postprandial LPL activity were significantly correlated with the respective exercise-induced changes in fasting TG concentration and the postprandial TG response (r=-0.70 and -0.77 respectively, P<0.05 for both). These data suggest that increased LPL activity may contribute to the hypotriglyceridaemic effect of moderate exercise, although other mechanisms are also likely to be involved.

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Section: Standardisation Prior To Both Experimentsmentioning

confidence: 93%

Effects of a brisk walk on lipoprotein lipase activity and plasma triglyceride concentrations in the fasted and postprandial states

et al. 2003

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“…It may be argued that the lack of synchronisation of the test meals with a given phase of the menstrual cycle may have influenced our results. We believe this is rather unlikely as menstrual cycle phase does not exert a significant effect on either fasting (Reed et al, 2000) or postprandial (Wendler et al, 1992) plasma TAG levels. Moreover, we examined TAG responses after the SFA and MUFA meals in five of our subjects who were studied during the same follicular phase of their menstrual cycle and found no significant differences.…”

Section: Discussionmentioning

confidence: 89%

Gender influence on plasma triacylglycerol response to meals with different monounsaturated and saturated fatty acid content

et al. 2004

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Objective: Both gender and meal fatty acid composition modulate postprandial triacylglycerol (TAG) metabolism, but little information exists on their interaction. We compared postprandial TAG concentrations in men and women after test meals differing in the proportion of monounsaturated (MUFA) and saturated fatty acids (SFA). Subjects: Nine men (body mass index, BMI: 24.572.3 kg/m 2 ) (mean7s.d.) and 10 premenopausal women (BMI: 21.271.7 kg/m 2 ), young and healthy, habituated to a relatively high MUFA diet. Design: Plasma responses were studied after subjects consumed two meals, each providing 60 g of fat and 4.7 MJ, on different occasions: one meal was rich in MUFA (MUFA meal: 40 g MUFA; 12 g SFA) and the other meal was rich in SFA (SFA meal: 20 g MUFA; 32 g SFA). The total body and abdominal fat mass were assessed by dual energy X-ray absorptiometry. Results: Fasting plasma TAG concentration did not differ between meals or genders. No gender differences were observed in either total body or abdominal fat mass. The area under the plasma concentration vs time curve was on average 60% higher (Po0.001) in men than women. Repeated measures ANOVA showed a significant effect of meal Â time interaction in men (Po0.001) but not in women (P ¼ 0.84). In men, maximal plasma TAG occurred at 4 h and was significantly greater after the MUFA meal (2.1070.20 mmol/l) (mean7s.e.m.) than after the SFA meal (1.6670.19 mmol/l) (P ¼ 0.01). TAG concentration at 5 h was also significantly greater after the MUFA meal. In women, the patterns of TAG responses were identical after the MUFA and SFA meals. Conclusions: This study provides evidence that gender influences postprandial TAG concentrations when meal fatty acid composition is altered.

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“…Women in the present study were in the follicular phase of their menstrual cycle. At least one study has suggested that the postprandial lipid response was not significantly different between the follicular and luteal phases of the menstrual cycle (47). Clearly, further studies are required to identify the factors regulating the lipemic response to meal ingestion in men and women.…”

Section: Discussionmentioning

confidence: 99%

Postprandial leg uptake of triglyceride is greater in women than in men

Horton¹,

Commerford²,

Pagliassotti

et al. 2002

American Journal of Physiology-Endocrinology and Metabolism

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leg uptake of triglyceride is greater in women than in men. Am J Physiol Endocrinol Metab 283: E1192-E1202, 2002 10.1152/ajpendo.00164. 2002The postprandial excursion of plasma triglyceride (TG) concentration is greater in men than in women. In this study, the disposition of dietary fat was examined in lean healthy men and women (n ϭ 8/group) in either the overnight-fasted or fed (4.5 h after breakfast) states. A [ 14 C]oleate tracer was incorporated into a test meal, providing 30% of total daily energy requirements. After ingestion of the test meal, measures of arteriovenous differences in TG and 14 C across the leg were combined with needle biopsies of skeletal muscle and adipose tissue and respiratory gas collections to define the role of skeletal muscle in the clearance of dietary fat. The postprandial plasma TG and 14 C tracer excursions were lower (P ϭ 0.04) in women than in men in the overnight-fasted and fed states. Women, however, had significantly greater limb uptake of total TG compared with men on both the fasted (3,849 Ϯ 846 vs. 528 Ϯ 221 total mol over 6 h) and fed (4,847 Ϯ 979 vs. 1,571 Ϯ 334 total mol over 6 h) days. This was also true for meal-derived 14 C lipid uptake.14 C content of skeletal muscle tissue (Ci/g tissue) was significantly greater in women than in men 6 h after ingestion of the test meal. In contrast, 14 C content of adipose tissue was not significantly different between men and women at 6 h. The main effect of nutritional state, fed vs. fasted, was to increase the postmeal glucose (P ϭ 0.01) excursion (increase from baseline) and decrease the postmeal TG excursion (P ϭ 0.02). These results support the notion that enhanced skeletal muscle clearance of lipoprotein TG in women contributes to their reduced postprandial TG excursion. Questions remain as to the mechanisms causing these sex-based differences in skeletal muscle TG uptake and metabolism. Furthermore, nutritional state can significantly impact postprandial metabolism in both men and women. dietary fat; gender; skeletal muscle AN ELEVATED POSTPRANDIAL TRIGLYCERIDE (TG) excursion is a significant and independent risk factor for coronary heart disease (CHD) (15,21,31,50) and carotid atherosclerosis (6, 39). In addition, a decreased ability to oxidize lipid is considered to be a risk factor for weight gain (7, 51). It is therefore important to understand the factors that regulate the metabolic response to the ingestion of dietary fat. In this context, there are sexbased differences in the incidence of CHD (4, 22) and to a lesser extent obesity (28), which may be due in part to sex-based differences in postprandial lipoprotein metabolism. Specifically, after ingestion of a mixed meal, circulating TG levels have been shown to be significantly higher in men compared with premenopausal women (12, 18, 29) despite nearly identical glucose and insulin responses. This sex-based difference in the postprandial TG response does not appear to be explained by differences in premeal fasting TG levels (12, 18). The consequence of a lower T...

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Menstrual Cycle Exhibits No Effect on Postprandial Lipemia

Cited by 13 publications

References 2 publications

Effects of a brisk walk on lipoprotein lipase activity and plasma triglyceride concentrations in the fasted and postprandial states

Effects of a brisk walk on lipoprotein lipase activity and plasma triglyceride concentrations in the fasted and postprandial states

Gender influence on plasma triacylglycerol response to meals with different monounsaturated and saturated fatty acid content

Postprandial leg uptake of triglyceride is greater in women than in men

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