Menstrual Cycle Affects Bladder Pain Sensation in Subjects With Interstitial Cystitis

Powell-Boone, Tykeysha; Ness, Timothy J.; Cannon, Ronda; Lloyd, L. Keith; Weigent, Douglas A.; Fillingim, Roger B.

doi:10.1097/01.ju.0000176747.40242.3d

Cited by 62 publications

(46 citation statements)

References 16 publications

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“…Leuprolide acetate. Many women of reproductive age with IC often complain of worsening symptoms during their menstrual cycle [Powell-Boone et al 2005]. This may be related to the fact that estradiol activates the estrogen receptors expressed on bladder mast cells, which in turn increases pro-inflammatory molecule secretion [Spanos et al 1996].…”

Section: Oral Medicationsmentioning

confidence: 99%

Role of inflammation in bladder function and interstitial cystitis

Grover

Srivastava

Lee

et al. 2011

Therapeutic Advances in Urology

163

129

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Cystitis, or inflammation of the bladder, has a direct effect on bladder function. Interstitial cystitis is a syndrome characterized by urinary bladder pain and irritative symptoms of more than 6 months duration. It commonly occurs in young to middle-aged women with no known cause and in fact represents a diagnosis of exclusion. Many factors have been suggested, including chronic or subclinical infection, autoimmunity and genetic susceptibility, which could be responsible for initiating the inflammatory response. However, a central role of inflammation has been confirmed in the pathogenesis of interstitial cystitis. Patients with interstitial cystitis are usually managed with multimodal therapy to break the vicious cycle of chronic inflammation at every step. Patients who develop irreversible pathologies such as fibrosis are managed surgically, which is usually reserved for refractory cases.

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Section: Oral Medicationsmentioning

confidence: 99%

Role of inflammation in bladder function and interstitial cystitis

Grover

Srivastava

Lee

et al. 2011

Therapeutic Advances in Urology

163

129

View full text Add to dashboard Cite

show abstract

“…Asthma is better controlled during pregnanc y, presumably due to high proge sterone levels. Uterine histamine secretion apparently occurs prior to ovulation (32), which may help explain why symptoms of PBS/IC and other autoimmune disorde rs worsen during the menstrual cycle ( 10). Estradiol can release histam ine in vivo (33)(34) and in vitro (15).…”

Section: Dose-response Ofprogesterone On Histamine Release Induced mentioning

confidence: 99%

“…These symptoms worsen during the menstrual cycle in most pre-menopausal women, but subside in late pregnancy (10).…”

mentioning

confidence: 99%

Progesterone Inhibits Mast Cell Secretion

Vasiadi

Kempuraj

Boucher

et al. 2006

Int J Immunopathol Pharmacol

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Mast cells are involved in allergic reactions, where they secrete numerous vasoactive, inflammatory and nociceptive mediators in response to immunoglobulin E (IgE) and antigen. However, they have also been implicated in inflammatory conditions, such as painful bladder syndrome/interstitial cystitis (PBSIIC), irritable bowel syndrome (IBS) and migraines, all of which occur more often in women and are exacerbated during ovulation, but are suppressed during pregnancy. Mast cells express high affinity estrogen receptors and estradiol augments their secretion, while tamoxifen inhibits it. Here we report that progesterone (100 nM), but not the structurally related cholesterol, inhibits histamine secretion from purified rat peritoneal mast cells stimulated immunologically or by substance P (SP), an effect also documented by electron microscopy. These results suggest that mast cell secretion may be regulated by progesterone and may explain the reduced symptoms of certain inflammatory conditions during pregnancy.

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“…Existe una relación de 9:1 entre mujeres y hombres (5), habiéndose demostrado que el dolor urogenital en mujeres está muy relacionado con la carga hormonal y con el ciclo menstrual (6)(7)(8).…”

Section: Introductionunclassified

Nueva técnica de radiofrecuencia pulsada en el tratamiento del dolor pélvico crónico. Presentación de dos casos

Cartagena-Sevilla

Rey

Vicente-Villena

et al. 2017

Rev. Soc. Esp. Dolor.

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. Nueva técnica de radiofrecuencia pulsada en el tratamiento del dolor pélvico crónico. Presentación de dos casos / New pulsed radiofrequency technique for the management of chronic pelvic pain. Report of two cases. Rev. Soc. Esp. Dolor. 2017. doi: 10.20986/resed.2017.3587/2017 Este es un archivo PDF de un manuscrito inédito que ha sido aceptado para su publicación en la Revista de la Sociedad Española del Dolor. Como un servicio a nuestros clientes estamos proporcionando esta primera versión del manuscrito en estado de prepublicación. El manuscrito será sometido a la corrección de estilo final, composición y revisión de la prueba resultante antes de que se publique en su forma final. Tenga en cuenta que durante el proceso de producción se pueden dar errores lo que podría afectar el contenido final. El copyright y todos los derechos legales que se aplican al artículo pertenecen a la Revista de la

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Menstrual Cycle Affects Bladder Pain Sensation in Subjects With Interstitial Cystitis

Cited by 62 publications

References 16 publications

Role of inflammation in bladder function and interstitial cystitis

Role of inflammation in bladder function and interstitial cystitis

Progesterone Inhibits Mast Cell Secretion

Nueva técnica de radiofrecuencia pulsada en el tratamiento del dolor pélvico crónico. Presentación de dos casos

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