Menstrual Bleeding as a Manifestation of Mini-Puberty of Infancy in Severe Prematurity

Vogiatzi, Maria G; Pitt, M B; Oberfield, Sharon E.; Alter, Craig A.

doi:10.1016/j.jpeds.2016.08.021

Cited by 15 publications

(19 citation statements)

References 14 publications

(37 reference statements)

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“…In the patient of this study periodic vaginal bleeding was seen same as Ivana, Gisselle, Bethany and Maria study [6,15,18]. That is not conventional event in mini puberty state in term infants.…”

Section: Discussionsupporting

confidence: 72%

“…However, after disconnection of hormonal therapy any signs of puberty did not develop and the initial diagnosis of central precocious puberty (CPP) was incorrect. [14] Patient in this study has pubic hairs, Same selim study [6] and unlike Gisselle [15] and Maria study [18]. This symptom is consequent on gonadal and adrenals androgens secretion concomitant with the LH changes in the mini-Puberty [6].…”

Section: Discussionmentioning

confidence: 85%

“…Most of the patients in similar articles also had long-term hospitalizations because of bronchopulmonary dysplasia, recurrent prematurity apnea, primary pulmonary hypertension, and patent ductus arteriosus, retinopathy of prematurity and even intracranial hemorrhage which all problems are the causes of in ammatory mechanisms in the body. [13,15,18,20] Synchronization of reduction in sex hormones and in ammatory markers (ferritin) may indicate that in ammatory process is an irritant marker for exaggerated puberty during infancy period (see the table). Likewise, in current study case, gradual regression of puberty symptoms concomitant to recovery of BPD symptoms and decrease to discontinuous of oxygen demand are observed.…”

Section: Discussionmentioning

confidence: 99%

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Exaggerated Mini Puberty of Early Infancy in the Preterm Girls: A Case Report and Systematic Review

Davoodi¹,

Ghobadi²,

Mahmoudi³

et al. 2020

Preprint

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Background: Mini puberty is the important period of infancy life that has several impressions to sexual development in both sexes. In the infants born very premature and extremely low birth weight, mini puberty changes including clinical, hormonal and imaging data are severe and long lasting, especially in girls. It can be called “exaggerated mini puberty”.Methods: In this study, 6-month preterm infant with bronchopulmonary dysplasia presented with periodic vaginal bleeding, breast stage tanner 3 and pubic hairs. We followed up infant by clinical and para clinical evaluations during one year and compared this data with all of the similar articles were published.Results: During one year monitoring of the infancy puberty presentation, gradually returned to the pre pubertal state, without excessive hormonal treatment. Conclusions: Due to this systematic review, exaggerated mini puberty is the temporary physiologic state in very low birth weight preterm infants that should be prevents any extra hormonal and surgical intervention.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exaggerated Mini Puberty of Early Infancy in the Preterm Girls: A Case Report and Systematic Review

Davoodi¹,

Ghobadi²,

Mahmoudi³

et al. 2020

Preprint

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“…It is particularly important to know the clinical course with vaginal bleeding, since this condition does not require examination, but only monitoring. Two cases include preterm infants with menstrual bleeding at the age of 6 months (CA 2.5 months), where the results showed the activation of the HPG axis and elevated levels of estrogen, but without swollen genitalia [9]. Vaginal bleeding in neonatal period usually occurs immediately after birth, as a result of child's endometrium's exposure to mother's estrogens during the fetal period and the fact that placental hormones cease to have effect.…”

Section: Discussionmentioning

confidence: 99%

Preterm Ovarian Hyperstimulation Syndrome: A Clinical Presentation of Three Cases

Vorgucin¹,

Katanic²,

Kovacevic³

et al. 2018

JGNB

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Objective: Preterm Ovarian Hyperstimulation Syndromeis a rare condition, presented with swollen genitalia in preterm female infants. The laboratory results detect elevated levels of estradiol and gonadotropins, while an ultrasound examination often verifies ovarian cysts. The cause of the condition is an immature hypothalamic-pituitary-gonadal axis. Methods/Results/Conclusion. We are going to show a mini series of three patients with preterm ovarian hyperstimulation syndrome with different clinical courses.

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“…Previously reported cases of infants with vaginal bleeding were born preterm or were small for their gestational age. These extreme cases of mini puberty detailed only 1–2 episodes of vaginal bleeding 16 17) . In girls, postnatal gonadotropin levels started to decrease after the peak at 1–3 months of age.…”

Section: Discussionmentioning

confidence: 99%

An 11-month-old girl with central precocious puberty caused by hypothalamic hamartoma

Yoon

Kim

2016

Ann Pediatr Endocrinol Metab

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Central precocious puberty (CPP) is caused by premature activation of the hypothalamic-gonadal axis, and must be treated adequately. In particular, CPP that occurs at a relatively young age or in boys is likely to be caused by an organic lesion. Hypothalamic hamartoma (HH) is the most common organic cause of CPP. The present case report describes an 11-month-old female infant who presented with vaginal bleeding and rapidly progressive secondary sex characteristics from the age of 6 months. She was diagnosed with CPP following the detection of HH via magnetic resonance imaging. The infant girl was successfully treated with gonadotropin-releasing hormone agonist. After 6 months, her breast had regressed and clinical and radiological follow-up demonstrated stable findings with no evidence of tumor growth or secondary sexual characteristics until the fourth year after the initiation of treatment. This patient is the one of the youngest infants presenting with CPP and HH in Korea; treatment was successful over a relatively long follow-up period.

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Menstrual Bleeding as a Manifestation of Mini-Puberty of Infancy in Severe Prematurity

Cited by 15 publications

References 14 publications

Exaggerated Mini Puberty of Early Infancy in the Preterm Girls: A Case Report and Systematic Review

Exaggerated Mini Puberty of Early Infancy in the Preterm Girls: A Case Report and Systematic Review

Preterm Ovarian Hyperstimulation Syndrome: A Clinical Presentation of Three Cases

An 11-month-old girl with central precocious puberty caused by hypothalamic hamartoma

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