Menopause, wellbeing and health: A care pathway from the European Menopause and Andropause Society

Lambrinoudaki, Ιrene; Armeni, Eleni; Goulis, Dimitrios G.; Bretz, Silvia; Ceaușu, Iuliana; Durmuşoğlu, Fatih; Erkkola, Risto; Fistonić, Ivan; Gambacciani, Marco; Geukes, Marije; Hamoda, Haitham; Hartley, Caiomhe; Hirschberg, Angelica Lindén; Męczekalski, Błażej; Mendoza, Nicolás; Mueck, Alfred O.; Smetnik, Antonina; Stute, Petra; Trotsenburg, Mick van; Rees, Margaret

doi:10.1016/j.maturitas.2022.04.008

Cited by 46 publications

(37 citation statements)

References 151 publications

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“…Thus, accordingly to the literature, there is no clear indication that a hysterectomy may either worsen or improve sexual function. On the other hand, alterations in sexual function can be related to RRSO, menopausal hormone withdrawal, and its accompanying changes, which are associated with a progressive worsening of sexual function [ 84 ] and can be mitigated by hormonal therapy [ 85 , 86 , 87 ].…”

Section: Resultsmentioning

confidence: 99%

“…Although they found a reduction in breast and ovarian cancer incidence and mortality after BRRM and RRSO, they also found significantly increased overall mortality rates compared to general population of age-matched women [ 130 ]. In general, surgical menopause under 45 years is associated with the worst menopausal symptoms and an increase in cardiovascular mortality [ 85 , 86 , 87 , 131 , 132 , 133 ].…”

Section: Resultsmentioning

confidence: 99%

“…Hormone therapy (HT) can be given to counteract the symptoms of early menopause, and it is also known to reduce mortality due to cardiovascular events when given at an early age or immediately after menopause [ 85 , 86 , 87 , 134 ]. HT alleviates menopausal symptoms, sexual dysfunction, bone loss, and the risk of fractures at any skeleton site [ 85 , 86 , 87 ]. It lowers the risk of cardiovascular disease when started within 10 years of menopause or before 60 years [ 85 , 86 , 87 ].…”

Section: Resultsmentioning

confidence: 99%

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Risk-Reducing Breast and Gynecological Surgery for BRCA Mutation Carriers: A Narrative Review

Bertozzi

Londero

Xholli

et al. 2023

JCM

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This narrative review aims to clarify the role of breast and gynecological risk-reduction surgery in BRCA mutation carriers. We examine the indications, contraindications, complications, technical aspects, timing, economic impact, ethical issues, and prognostic benefits of the most common prophylactic surgical options from the perspectives of a breast surgeon and a gynecologist. A comprehensive literature review was conducted using the PubMed/Medline, Scopus, and EMBASE databases. The databases were explored from their inceptions to August 2022. Three independent reviewers screened the items and selected those most relevant to this review’s scope. BRCA1/2 mutation carriers are significantly more likely to develop breast, ovarian, and serous endometrial cancer. Because of the Angelina effect, there has been a significant increase in bilateral risk-reducing mastectomy (BRRM) since 2013. BRRM and risk-reducing salpingo-oophorectomy (RRSO) significantly reduce the risk of developing breast and ovarian cancer. RRSO has significant side effects, including an impact on fertility and early menopause (i.e., vasomotor symptoms, cardiovascular disease, osteoporosis, cognitive impairment, and sexual dysfunction). Hormonal therapy can help with these symptoms. Because of the lower risk of developing breast cancer in the residual mammary gland tissue after BRRM, estrogen-only treatments have an advantage over an estrogen/progesterone combined treatment. Risk-reducing hysterectomy allows for estrogen-only treatments and lowers the risk of endometrial cancer. Although prophylactic surgery reduces the cancer risk, it has disadvantages associated with early menopause. A multidisciplinary team must carefully inform the woman who chooses this path of the broad spectrum of implications, from cancer risk reduction to hormonal therapies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Risk-Reducing Breast and Gynecological Surgery for BRCA Mutation Carriers: A Narrative Review

Bertozzi

Londero

Xholli

et al. 2023

JCM

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“…However, ovarian conservation is only used in 8–10% of eligible women with EC [ 2 , 14 ]. The use of HT seems even safer than ovarian conservation on EC risk [ 18 ] and would be useful in reducing menopausal symptoms, sexual disturbances, bone loss, fracture risk, cardiovascular risk, and cognitive impairment [ 6 , 7 , 8 ]. However, no more than 10% EC survivors use HT [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…HT lowers the incidence of fractures at any point on the skeleton, as well as bone loss, menopausal symptoms, and sexual difficulties. When begun within ten years of menopause or before the age of 60, this reduces the risk of cardiovascular disease [ 6 , 7 , 8 ]. These protections are strengthened when HT is applied to women experiencing early or premature menopause, including those driven on by ovariectomy, in addition to reducing cognitive impairment [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Women Who Could Benefit from Hormone Therapy after Endometrial Cancer Treatment: An Analysis of SEER Data

et al. 2022

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Our primary aim was to estimate the magnitude of stage I endometrial cancer (EC) survivors that could benefit from hormonal therapy (HT). Our secondary aims were to assess EC incidence in women below 50 and below 60 over the years, and analyze the overall survival and any influencing factors. We analyzed the endometrioid EC data from the Surveillance, Epidemiology, and End Results (SEER) program according to women’s age, tumor stage, and grade. We analyzed the proportions of EC survivors below 50 and below 60 years of age and stratified those age groups by race. For age distribution and survival analysis SEER, 18 registries’ research data (2000–2018) were analyzed. We analyzed the SEER 12 registries’ research data (1992–2019) for incidence time trends. Our investigation found a 14% and 40% cumulative prevalence of stage I EC that occurs in women below 50 or 60 years, respectively. EC’s prevalence has progressively risen in recent decades, but cancer-specific mortality remains low. The increasing number of women affected by EC in premenopause or early postmenopause face an 18 years-survival rate of 96.86% and 95.73%, respectively. A significant proportion of low-grade EC survivors can potentially benefit from HT treatment, and this requires awareness of other aspects of their health or quality of life, in addition to cancer treatments.

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Public Health Challenges and Responses to the Growing Ageing Populations

Khan,

Addo,

Findlay

2024

Public Health Challenges

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BackgroundHuman populations are rapidly ageing worldwide due to declining birth rates and rising life expectancies. This profound demographic shift presents complex public health challenges. Synthesizing evidence on key public health issues impacting ageing populations and policy strategies is required to address these needs.MethodsThe study employs narrative literature review based on the PubMed database. Data have been extracted on public health challenges to ageing populations and its recommended policy solutions.ResultsThe key public health challenges identified include rising chronic disease burden, risks for preventable multi‐morbidities and co‐morbidities, disability and dependencies, mental health issues, caregiving gaps, long‐term care system deficiencies, health inequities, healthcare access barriers, end‐of‐life care needs, financial instability, ageism/elder abuse, adverse built environments, climate/disaster threats, and social isolation. Evidence‐based policy responses span interventions in healthcare, social services, urban planning, emergency preparedness, economics, technology, anti‐ageism advocacy and so on.ConclusionsProactively addressing the array of public health challenges faced by rapidly growing ageing populations globally requires implementing collaborative, multisectoral policy solutions focused on promoting healthy, equitable, and socially engaged ageing. Healthcare systems, communities, and policies must be optimized to meet the needs of elderly people and tap into their strengths.

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Menopause, wellbeing and health: A care pathway from the European Menopause and Andropause Society

Cited by 46 publications

References 151 publications

Risk-Reducing Breast and Gynecological Surgery for BRCA Mutation Carriers: A Narrative Review

Risk-Reducing Breast and Gynecological Surgery for BRCA Mutation Carriers: A Narrative Review

Quantification of Women Who Could Benefit from Hormone Therapy after Endometrial Cancer Treatment: An Analysis of SEER Data

Public Health Challenges and Responses to the Growing Ageing Populations

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