Abstract:Background Medical attention for menopausal women is frequently delivered by health care providers (general practitioners, gynecologists or homeopathic physicians) who are not specialized in post-reproductive care. Homeopathy has been used for treating menopausal complaints for more than two centuries. Therefore, it is important to improve clinical knowledge in this field among homeopathic physicians. Nowadays, there is a special interest in the study of menopause-related chronic conditions due to the impact o… Show more
“…Medicines are prepared by serial dilution and shaking, which proponents claim imprints information into water.” 3 The importance of a comprehensive and individualized homeopathic evaluation for improving homeopathic prescription in daily clinical practice has been described. 4 Sepia officinalis , Lachesis mutus , Sanguinaria canadensis , Sulphur and Cimicifuga racemosa are among the well-known homeopathic medicines (HMs) prescribed for menopause. Both observational studies and case reports have reported encouraging results when prescribing these HMs for menopause, 5 6 7 but few randomized controlled trials in this area have shown positive results.…”
Background Menopause is a physiological event that marks the end of a woman's reproductive stage in life. Vasomotor symptoms and changes in mood are among its most important effects. Homeopathy has been used for many years in treating menopausal complaints, though clinical and pre-clinical research in this field is limited. Homeopathy often bases its prescription on neuropsychiatric symptoms, but it is unknown if homeopathic medicines (HMs) exert a neuroendocrine effect that causes an improvement in vasomotor symptoms and mood during menopause.
Objectives The study's objectives were to address the pathophysiological changes of menopause that could help in the understanding of the possible effect of HMs at a neuroendocrine level, to review the current evidence for two of the most frequently prescribed HMs for menopause (Lachesis mutus and Sepia officinalis), and to discuss the future directions of research in this field.
Methods An extensive literature search for the pathophysiologic events of menopause and depression, as well as for the current evidence for HMs in menopause and depression, was performed.
Results Neuroendocrine changes are involved in the pathophysiology of vasomotor symptoms and changes in mood during menopause. Gonadal hormones modulate neurotransmitter systems. Both play a role in mood disorders and temperature regulation. It has been demonstrated that Gelsemium sempervirens, Ignatia amara and Chamomilla matricaria exert anxiolytic effects in rodent models. Lachesis mutus and Sepia officinalis are frequently prescribed for important neuropsychiatric and vasomotor symptoms. Dopamine, a neurotransmitter involved in mood, is among the constituents of the ink of the common cuttlefish, Sepia officinalis.
Conclusion Based on all the pathophysiologic events of menopause and the improvement in menopausal complaints that certain HMs show in daily practice, these medicines might have a direct or indirect neuroendocrine effect in the body, possibly triggered via an as-yet unidentified biological mechanism. Many unanswered questions in this field require further pre-clinical and clinical research.
“…Medicines are prepared by serial dilution and shaking, which proponents claim imprints information into water.” 3 The importance of a comprehensive and individualized homeopathic evaluation for improving homeopathic prescription in daily clinical practice has been described. 4 Sepia officinalis , Lachesis mutus , Sanguinaria canadensis , Sulphur and Cimicifuga racemosa are among the well-known homeopathic medicines (HMs) prescribed for menopause. Both observational studies and case reports have reported encouraging results when prescribing these HMs for menopause, 5 6 7 but few randomized controlled trials in this area have shown positive results.…”
Background Menopause is a physiological event that marks the end of a woman's reproductive stage in life. Vasomotor symptoms and changes in mood are among its most important effects. Homeopathy has been used for many years in treating menopausal complaints, though clinical and pre-clinical research in this field is limited. Homeopathy often bases its prescription on neuropsychiatric symptoms, but it is unknown if homeopathic medicines (HMs) exert a neuroendocrine effect that causes an improvement in vasomotor symptoms and mood during menopause.
Objectives The study's objectives were to address the pathophysiological changes of menopause that could help in the understanding of the possible effect of HMs at a neuroendocrine level, to review the current evidence for two of the most frequently prescribed HMs for menopause (Lachesis mutus and Sepia officinalis), and to discuss the future directions of research in this field.
Methods An extensive literature search for the pathophysiologic events of menopause and depression, as well as for the current evidence for HMs in menopause and depression, was performed.
Results Neuroendocrine changes are involved in the pathophysiology of vasomotor symptoms and changes in mood during menopause. Gonadal hormones modulate neurotransmitter systems. Both play a role in mood disorders and temperature regulation. It has been demonstrated that Gelsemium sempervirens, Ignatia amara and Chamomilla matricaria exert anxiolytic effects in rodent models. Lachesis mutus and Sepia officinalis are frequently prescribed for important neuropsychiatric and vasomotor symptoms. Dopamine, a neurotransmitter involved in mood, is among the constituents of the ink of the common cuttlefish, Sepia officinalis.
Conclusion Based on all the pathophysiologic events of menopause and the improvement in menopausal complaints that certain HMs show in daily practice, these medicines might have a direct or indirect neuroendocrine effect in the body, possibly triggered via an as-yet unidentified biological mechanism. Many unanswered questions in this field require further pre-clinical and clinical research.
“…In her review article on menopausal syndrome, Dr Emma Macías-Cortés emphasises that knowing the biology of the neuroendocrine changes associated with the menopause can help to inform the rationale for specific homeopathic prescribing, suggesting also how and where in the body those medicines might act. 1 The fact that 5% of the world's population is projected to have pre-diabetes by the year 2030 prompted Dr Nilanjana Guha and colleagues to undertake a randomised controlled trial (RCT) on the topic: compared with placebo, individually prescribed homeopathic medicines showed some improvement in fasting blood sugar levels, though not in glucose tolerance, indicating that homeopathy might offer modest benefit. 2 For the animal kingdom, mastitis-metritis-agalactia (MMA) is a commonly seen syndrome in post-partum sows: in an RCT of homeopathic prophylaxis, however, Dr Kathrin Büttner et al did not detect any improvement in occurrence of MMA in sows that received a combination of two specialised complex homeopathic remedies.…”
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