Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study

Bermingham, Kate; Linenberg, Inbar; Hall, Wendy; Kadé, Kirstin; Franks, Paul W.; Davies, Richard; Wolf, Jonathan; Hadjigeorgiou, George; Asnicar, Francesco; Segata, Nicola; Manson, JoAnn E.; Newson, Louise; Delahanty, Linda M.; Ordovás, José M.; Chan, Andrew T.; Spector, Tim D.; Valdes, Ana M.; Berry, Sarah

doi:10.1016/j.ebiom.2022.104303

Cited by 19 publications

(18 citation statements)

References 34 publications

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“…Traditionally most research has focused on male subjects and there is a need to undertake more research on female health. A recent study, the first of its kind examined the impact of menopause on women’s metabolism, as well as diet and how this related to their overall health [ 114 ]. The study indicated that diet and gut microbial species may have been responsible for changes observed after menopause such as higher blood pressure and a greater risk of developing cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

The Gut Microbiome and Female Health

Siddiqui

Makhlouf

Alharbi

et al. 2022

Biology

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The possession of two X chromosomes may come with the risk of various illnesses, females are more likely to be affected by osteoarthritis, heart disease, and anxiety. Given the reported correlations between gut microbiome dysbiosis and various illnesses, the female gut microbiome is worthy of exploration. Herein, we discuss the composition of the female gut microbiota and its dysbiosis in pathologies affecting the female population. Using PubMed, we performed a literature search, using key terms, namely: “gut microbiome”, “estrogen”, “menopause”, “polycystic ovarian syndrome”, “pregnancy”, and “menstruation”. In polycystic ovarian syndrome (PCOS), the abundance of Bacteroides vulgatus, Firmicutes, Streptococcus, and the ratio of Escherichia/Shigella was found to be increased while that of Tenericutes ML615J-28, Tenericutes 124-7, Akkermansia, Ruminococcaceae, and Bacteroidetes S24-7 was reduced. In breast cancer, the abundance of Clostridiales was enhanced, while in cervical cancer, Prevotella, Porphyromonas, and Dialister were enhanced but Bacteroides, Alistipes, and members of Lachnospiracea, were decreased. In ovarian cancer, Prevotella abundance was increased. Interestingly, the administration of Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus reuteri, and Lactobacillus fermentum ameliorated PCOS symptoms while that of a mix of Bifidobacterium lactis W51, Bifidobacterium bifidum W23, Lactobacillus brevis W63, Bifidobacterium lactis W52, Lactobacillus salivarius W24, Lactobacillus acidophilus W37, Lactococcus lactis W19, Lactobacillus casei W56, and Lactococcus lactis W58 alleviated vascular malfunction and arterial stiffness in obese postmenopausal women, and finally, while further research is needed, Prevotella maybe protective against postmenopausal bone mass loss. As several studies report the therapeutic potential of probiotics and since the gut microbiota of certain female pathological states has been relatively characterized, we speculate that the administration of certain bacterial species as probiotics is warranted, as novel independent or adjunct therapies for various female pathologies.

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Section: Discussionmentioning

confidence: 99%

The Gut Microbiome and Female Health

Siddiqui

Makhlouf

Alharbi

et al. 2022

Biology

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“…Research has also shown the benefits of exercise in modifying gut microbial populations [ 154 ]. A recent study involving a large cohort of postmenopausal women revealed important interactions between hormonal, physiological, and dietary factors that may synergize as determinants of metabolic risk [ 155 ]. Interestingly, data has shown that the gut may play an important mediating role in predicting risk among postmenopausal women.…”

Section: Nutritional Approaches To Improve Metabolic Health Following...mentioning

confidence: 99%

“…Regarding HRT, favorable associations were found for visceral adiposity as well as fasting and postprandial metabolic indicators. Statistical analyses have revealed new and potentially significant associations between diet, gut microbial changes, and health indicators [ 155 ]. Importantly, this study highlights the profound impact of diet and lifestyle protections for aging women and supports a closer look at HRT, especially for women with high susceptibility for metabolic disease who do not have contraindicated health risks, such as a history of reproductive cancers.…”

Section: Nutritional Approaches To Improve Metabolic Health Following...mentioning

confidence: 99%

Adipocyte Metabolism and Health after the Menopause: The Role of Exercise

2023

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Postmenopausal women represent an important target population in need of preventative cardiometabolic approaches. The loss of estrogen following the menopause eliminates protections against metabolic dysfunction, largely due to its role in the health and function of adipose tissue. In addition, some studies associate the menopause with reduced physical activity, which could potentially exacerbate the deleterious cardiometabolic risk profile accompanying the menopause. Meanwhile, exercise has adipocyte-specific effects that may alleviate the adverse impact of estrogen loss through the menopausal transition period and beyond. Exercise thus remains the best therapeutic agent available to mitigate menopause-associated metabolic dysfunction and represents a vital behavioral strategy to prevent and alleviate health decline in this population.

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“…It is the gut microbial metabolites which link the microbiota and the immune system and modulate various aspects of immune cell function through a plethora of mechanisms [ 2 , 3 ]. Gut microbial dysbiosis has been associated with various pathologies such as cancer, infectious diseases, ageing, obesity, and more recently the gut microbial changes pertaining to female health issues are beginning to come to light [ 4 , 5 , 6 , 7 ]. Given that there is a dearth of studies on females, future studies to understand gut microbial changes during menopause, pregnancy, menstruation, osteoarthritis, and cancer are warranted.…”

mentioning

confidence: 99%