Menopause effect on blood Fe and Cu isotope compositions

Jaouen, Klervia; Balter, Vincent

doi:10.1002/ajpa.22430

Cited by 36 publications

(38 citation statements)

References 30 publications

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“…Iron and copper isotope variability in male versus female blood is different (Walczyk & von Blanckenburg ; Jaouen et al . ) and the fractionation process behind it could be due to menstruation (Jaouen & Balter ). Jaouen et al .…”

Section: Non‐traditional Isotopes In Modern Faunasmentioning

confidence: 99%

Non‐traditional isotope perspectives in vertebrate palaeobiology

2017

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The recent development of Multi-Collector Inductively Coupled PlasmaMass Spectrometry (MC-ICPMS), notably in the disciplines of earth sciences, now allows the measurement of precise isotope ratios, even under low concentration. Nontraditional isotope systems, such as alkaline earth (Ca, Mg) and transition (Cu, Fe, Zn) metals are now being measured in a variety of biological tissues, including bone and teeth. Although our understanding of the environmental and biological mechanisms behind the fractionation of such elements is still in its infancy, some of these isotopes are suspected to fractionate along the food chain as has been reported in the literature for calcium, magnesium and zinc. Other geochemical methods, such as concentration analyses permit a prior assessment of diagenesis in the fossils to be analysed and such an approach allows recognising that in some circumstances, not only enamel but also dentine or bone can preserve its original biogenic composition. The aims here are to review the current knowledge surrounding these various isotopic tools, address their potential preservation in biological apatite and provide the palaeobiologist a guide on the different toolkits available and discuss their potential applications in vertebrate palaeobiology with a case study involving two mammal assemblages from the Pleistocene of Europe.Key words: non-traditional isotopes, palaeobiology, calcium, cave bear, Pleistocene.GEOCHEMICAL tools are a great asset to infer biological characteristics in fossil organisms that otherwise would remain completely unnoticed with morphological 2 observations alone. Among stable isotopes, carbon (C), oxygen (O) and nitrogen (N) have been and are still widely used in ecology, archaeology and in palaeoecology.From the vertebrate individual organism to the community, it is possible to reconstruct body temperatures and infer thermophysiology, reconstruct ambient palaeoenvironmental conditions and infer habitat use and migrations; and last but not least to reconstruct diet and trophic structures in ancient food webs. Most isotope approaches rely on stable isotope ratios of carbon and oxygen but also on radiogenic strontium preserved in fossilised tooth and bone. Elemental concentrations have also proved useful in many contexts such as dietary inference. For example, elemental ratios of strontium to calcium or barium to calcium allow reconstructing ecosystem structures.Contrary to light isotope systems, which have a variability beyond 10 ‰, nontraditional isotopes comprising alkaline earths (Ca, Mg) or transition metals (Cu, Fe, Zn), show isotope variability within a maximum range of 2-3‰. Recent analytical progresses from the domains of earth sciences now allow the measurement of such stable isotope systems, which show limited fractionation and require high precision and accuracy of measurements from mass spectrometers. The main basis for all those geochemical applications is already starting to be applied to archaeological studies (see review by Jaouen and Pons, 2016...

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Section: Non‐traditional Isotopes In Modern Faunasmentioning

confidence: 99%

Non‐traditional isotope perspectives in vertebrate palaeobiology

2017

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“…The first studies focusing on copper (Cu) and zinc (Zn) isotopic variations in human tissues were conducted on blood samples (Table ). In blood, δ 65 Cu values vary according to biological sex (Albarède, Telouk, Lamboux, Jaouen, & Balter, ), menopause (Jaouen & Balter, ; Van Heghe, Deltombe, Delanghe, Depypere, & Vanhaecke, ), and metabolic diseases (Aramendía, Rello, Resano, & Vanhaecke, ; Balter et al, ; Costas‐Rodríguez et al, ; Resano et al, ; Télouk et al, ) and possibly diet (Van Heghe, Engström, Rodushkin, Cloquet, & Vanhaecke, ). While the δ 66 Zn values in blood do not differ between men and women (Albarède et al, ; Van Heghe et al, ), the values are impacted by diseases (Larner et al, ; Stenberg et al, ) and diet (Costas‐Rodríguez, Van Heghe, & Vanhaecke, ; Van Heghe et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Menstruation has an influence on Cu isotope fractionation in women (Jaouen & Balter, ; Van Heghe et al, ) and, as a result, women's blood is depleted in Cu heavy isotopes in comparison with that of men (Albarède et al, ). The compact bone of men and women exhibit the same Cu isotopic pattern as blood, indicating the biological sex of human remains using the mineral phase of fossil bone (Jaouen et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…The compact bone of men and women exhibit the same Cu isotopic pattern as blood, indicating the biological sex of human remains using the mineral phase of fossil bone (Jaouen et al, ). After menopause, the Cu isotope ratio of women's blood is shifted toward that of men (Jaouen & Balter, ; Van Heghe et al, ). Bones are remodeled throughout the lifespan and record approximately the last 10 years of life (Hedges, Clement, David, Thomas, & O'Connell, ; Pate, ; Stenhouse & Baxter, ).…”

Section: Introductionmentioning

confidence: 99%

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Copper and zinc isotope ratios in human bone and enamel

Jaouen

Herrscher

Balter

2016

American J Phys Anthropol

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Our study demonstrates that the Cu and Zn isotope compositions of dental enamel are promising tools for childhood diet reconstruction. Meanwhile, the Cu isotope ratio of tooth enamel is unlikely to be useful for the identification of biological sex, even in the case of populations with early menarche. Further works are needed to understand the relationships between trophic level and Zn isotope ratios of human remains.

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“…Cu ratio, expressed in delta units (Method), varies between organs from −1‰ in liver to +1‰ in kidney (6) (for comparison, this ratio ranges from −3‰ to +2.5‰ in terrestrial materials). In humans, the 65 Cu/ 63 Cu ratio in blood and bone differs between men and women (7,8), partly because a sizeable proportion of the women's blood copper comes from the liver to balance menstrual losses (9,10). The body 65 Cu/ 63 Cu ratio varies according to that of diet (11) and also seems to be age dependent (12).…”

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confidence: 99%

Natural variations of copper and sulfur stable isotopes in blood of hepatocellular carcinoma patients

Balter

Costa

Bondanese

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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127

123

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The widespread hypoxic conditions of the tumor microenvironment can impair the metabolism of bioessential elements such as copper and sulfur, notably by changing their redox state and, as a consequence, their ability to bind specific molecules. S-enriched by ∼1.5‰ in the blood of patients compared with that of control subjects. As expected, HCC patients have more copper in red blood cells and serum compared with control subjects. However, the isotopic signature of this blood extra copper burden is not in favor of a dietary origin but rather suggests a reallocation in the body of copper bound to cysteine-rich proteins such as metallothioneins. The magnitude of the sulfur isotope effect is similar in red blood cells and serum of HCC patients, implying that sulfur fractionation is systemic. The 32 S-enrichment of sulfur in the blood of HCC patients is compatible with the notion that sulfur partly originates from tumor-derived sulfides. The measurement of natural variations of stable isotope compositions, using techniques developed in the field of Earth sciences, can provide new means to detect and quantify cancer metabolic changes and provide insights into underlying mechanisms. stable isotopes | copper | sulfur | liver | cancer

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Menopause effect on blood Fe and Cu isotope compositions

Cited by 36 publications

References 30 publications

Non‐traditional isotope perspectives in vertebrate palaeobiology

Non‐traditional isotope perspectives in vertebrate palaeobiology

Copper and zinc isotope ratios in human bone and enamel

Natural variations of copper and sulfur stable isotopes in blood of hepatocellular carcinoma patients

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