Menopause and Risk of Kidney Stones

Prochaska, Megan; Taylor, Eric N.; Curhan, Gary C.

doi:10.1016/j.juro.2018.04.080

Cited by 35 publications

(33 citation statements)

References 14 publications

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“…Our study also demonstrated the demographic differences between premenopausal and postmenopausal women with urolithiasis. Despite the relatively low number of patients in our study, the nding that postmenopausal women had a higher prevalence of hypertension, lower BMD, and hypocitraturia was consistent with current evidence [27], implying that postmenopausal status was associated with a higher risk of urolithiasis.…”

Section: Discussionsupporting

confidence: 89%

Low Bone Mineral Density is a Potential Risk Factor for Symptom Onset and Related with Hypocitraturia in Urolithiasis Patients: A Single-Center Retrospective Cohort Study

Taguchi

Hamamoto

Okada

et al. 2020

Preprint

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Background: Patients with urolithiasis have a lower bone mineral density (BMD) than those without stones, suggesting a potential correlation between calcium stone formation and bone resorption disorders, including osteopenia and osteoporosis. Methods: To investigate the influence of BMD on clinical outcomes in urolithiasis, we performed a single-center retrospective cohort study to analyze patients with urolithiasis who underwent both BMD examination and 24-hour urine collection between 2006 and 2015. Data from the national cross-sectional surveillance of the Japanese Society on Urolithiasis Research in 2015 were utilized, and additional data related to urinary tract stones were obtained from medical records. The primary outcome was the development of stone-related symptoms and recurrences during follow-up. A total of 370 patients were included in this 10-year study period. Results: Half of the patients had recurrent stones, and the two-thirds were symptomatic stone formers. While only 9% of patients had hypercalciuria, 27% and 55% had hyperoxaluria and hypocitraturia, respectively. There was a positive correlation between T-scores and urinary citrate excretion. Both univariate and multivariate analyses demonstrated that female sex was associated with recurrences (odds ratio=0.44, p=0.007), whereas a T-score <−2.5 and hyperoxaluria were associated with symptoms (odds ratio=2.59, p=0.037; odds ratio=0.45, p=0.01; respectively). Conclusion: These results revealed that low T-scores might cause symptoms in patients with urolithiasis, suggesting the importance of BMD examination for high-risk Japanese patients with urolithiasis having hypocitraturia.

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Section: Discussionsupporting

confidence: 89%

Low Bone Mineral Density is a Potential Risk Factor for Symptom Onset and Related with Hypocitraturia in Urolithiasis Patients: A Single-Center Retrospective Cohort Study

Taguchi

Hamamoto

Okada

et al. 2020

Preprint

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“…The key nding in this study is that an signi cant difference in uCA-2 excretion by ELISA analysis could discriminate patients with urinary stones from healthy controls. If our results are supported by many prospective validation studies, such a test might be clinically bene cial in the surveillance of high-risk patients, such as patients with metabolic syndrome [1][2][3][4] , in ammatory bowel disease 18 and accepted bariatric surgery 19 et al High risk of stone recurrence patients may also reap the bene ts of our results.…”

Section: Discussionsupporting

confidence: 59%

“…A number of potential metabolic [1][2][3] , genetic [4][5][6] , drug-induced 7,8 , and epidemiological 9,10 factors for urolithiasis have been reported. The knowledge of these factors contributes in determining the most appropriate therapy for each patient.…”

Section: Introductionmentioning

confidence: 99%

Urine CA-2 as a biomarker for diagnosis urinary stone and prediction of its complications

Leng

Zhou

et al. 2020

Preprint

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PURPOSECarbonic anhydrase-2 (CA-2) plays a role in mineralization and calcification in organism. Strong evidence suggests that CA-2 is associated with urolithiasis. However, the relationship between CA-2 and urinary stone remains unclear. The study aimed to assess the association of urine CA-2 (uCA-2) level and the potential risk of urinary stone.METHODSFrom March 2017 to November 2019, a prospective cohort study was conducted on patients with urinary stones and healthy subjects to determine the pretreatment uCA-2 level detection by Enzyme linked immunosorbent assay (ELISA). The difference of uCA-2 level between patients with urinary stones and healthy subjects was compared. Then comparison between stone patients with complications and without complications was carried out as well as correlation analysis to detect factors associated with biomarker expression.RESULTS118 patients with urinary stones were into urinary stones group and 42 healthy subjects were into healthy control group. The mean pretreatment uCA-2 level was significantly higher in patients with urinary stones group than healthy controls group (P=0.028). Furthermore, The uCA-2 level was positive correlation with urinary stones complications (R=0.379, P=0.000), especially pain complications (R=0.524, P=0.000) and hematuria complications (R=0.374, P=0.000). Receiver operating characteristic curve (ROC) analysis that a uCA-2 level threshold of 10.94 ng/mL had 83.67% sensitivity and 68.12% specificity for predicting urinary stones complications. CONCLUSIONSExcessive uCA-2 excretion is a major risk factor for urinary stone. Our findings suggested that uCA-2 may be used as an unappreciated biomarker for the diagnosis urinary stone in patients and to predict its complications.

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“…Therefore, we conclude that in China, those most likely to experience urolithiasis are of economically productive age, which could be associated with a high level of physical labour, excessive sweating, and low water intake. In two age subgroups 51–60 and 61–70 years, in which the ratio of male:female was <2, females submitted more stones than other age subgroups, which may be associated with menopausal oestrogen decline after the age of 50 years .…”

Section: Discussionmentioning

confidence: 93%

The status and characteristics of urinary stone composition in China

Zeng

Yang

et al. 2020

BJU International

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Epidemiology ObjectivesTo explore characteristics of urinary stone composition in China, and determine the effects of gender, age, body mass index (BMI), stone location, and geographical region on stone composition. Patients and methodsWe prospectively used Fourier-transform infrared spectroscopy to analyse stones from consecutive patients presenting with new-onset urolithiasis at 46 hospitals in seven geographical areas of China, between 1 June 2010 and 31 May 2015. Chi-squared tests and logistic regression analyses were used to determine associations between stone composition and gender, age, BMI, stone location, and geographical region. ResultsThe most common stone constituents were: calcium oxalate (CaOx; 65.9%), carbapatite (15.6%), urate (12.4%), struvite (2.7%), and brushite (1.7%). CaOx and urate stones occurred more frequently in males, whereas carbapatite and struvite were more common in females (P < 0.01). CaOx and carbapatite were more common in those aged 30-50 and 20-40 years than in other groups. Brushite and struvite were most common amongst those aged <20 and >70 years. The detection rate of urate increased with age, whilst cystine decreased with age. Obese patients were more likely to have urate stones than carbapatite or brushite stones (P < 0.01). CaOx, carbapatite, brushite, and cystine stones were more frequently found in the kidney than other types, whereas urate and struvite were more frequent in the bladder (P < 0.01). Stone composition varied by geographical region. ConclusionsThe most common stone composition was CaOx, followed by carbapatite, urate, struvite, and brushite. Stone composition differed significantly in patients grouped by gender, age, BMI, stone location, and geographical region.

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Menopause and Risk of Kidney Stones

Cited by 35 publications

References 14 publications

Low Bone Mineral Density is a Potential Risk Factor for Symptom Onset and Related with Hypocitraturia in Urolithiasis Patients: A Single-Center Retrospective Cohort Study

Low Bone Mineral Density is a Potential Risk Factor for Symptom Onset and Related with Hypocitraturia in Urolithiasis Patients: A Single-Center Retrospective Cohort Study

Urine CA-2 as a biomarker for diagnosis urinary stone and prediction of its complications

The status and characteristics of urinary stone composition in China

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Menopause and Risk of Kidney Stones

Cited by 35 publications

References 14 publications

Low Bone Mineral Density is a Potential Risk Factor for Symptom Onset and Related with Hypocitraturia in Urolithiasis Patients: A Single-Center Retrospective Cohort Study

Low Bone Mineral Density is a Potential Risk Factor for Symptom Onset and Related with Hypocitraturia in Urolithiasis Patients: A Single-Center Retrospective Cohort Study

Urine CA-2 as a biomarker for diagnosis urinary stone and prediction of&nbsp;its complications

The status and characteristics of urinary stone composition in China

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Urine CA-2 as a biomarker for diagnosis urinary stone and prediction of its complications