Menopause and cognitive complaints: are ovarian hormones linked with subjective cognitive decline?

Reuben, Rebekah; Karkaby, Laurice; McNamee, Clara; Phillips, Natalie A.; Einstein, Gillian

doi:10.1080/13697137.2021.1892627

Cited by 24 publications

(18 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, the type of hormone treatment (HT; E2 or in combination with progestins) and its duration may also have a bearing on the risk of depression, but knowledge of this is limited. Similarly, increasing evidence put forward a link between menopause and risk of subjective cognitive decline [ 70 ], which is often reported by menopausal women [ 71 ], and is associated with increased risk of developing AD later in life [ 72 ]. A recent systematic review demonstrated that the menopausal transition associates negatively with attention, and verbal and working memory [ 71 ].…”

Section: Estrogen Receptors and Healthy Ageing Of The Brainmentioning

confidence: 99%

Estrogen receptors and the aging brain

Maioli

Leander

Nilsson

et al. 2021

Essays in Biochemistry

View full text Add to dashboard Cite

The female sex hormone estrogen has been ascribed potent neuroprotective properties. It signals by binding and activating estrogen receptors that, depending on receptor subtype and upstream or downstream effectors, can mediate gene transcription and rapid non-genomic actions. In this way, estrogen receptors in the brain participate in modulating neural differentiation, proliferation, neuroinflammation, cholesterol metabolism, synaptic plasticity, and behavior. Circulating sex hormones decrease in the course of aging, more rapidly at menopause in women, and slower in men. This review will discuss what this drop entails in terms of modulating neuroprotection and resilience in the aging brain downstream of spatiotemporal estrogen receptor alpha (ERα) and beta (ERβ) signaling, as well as in terms of the sex differences observed in Alzheimer’s disease (AD) and Parkinson’s disease (PD). In addition, controversies related to ER expression in the brain will be discussed. Understanding the spatiotemporal signaling of sex hormones in the brain can lead to more personalized prevention strategies or therapies combating neurodegenerative diseases.

show abstract

Section: Estrogen Receptors and Healthy Ageing Of The Brainmentioning

confidence: 99%

Estrogen receptors and the aging brain

Maioli

Leander

Nilsson

et al. 2021

Essays in Biochemistry

View full text Add to dashboard Cite

show abstract

“…Two large population-based prospective cohort studies in the US reported a 44% to 62% prevalence of subjective cognitive decline among women undergoing the menopausal transition [ 28 , 29 ]. Loss of ovarian hormones have been theorized as the cause of cognitive complaints and SCD in women undergoing menopause [ 30 ]. However, declines in ovarian hormones do not explain the rebound of memory that prior large longitudinal studies report among post-menopausal women [ 31 , 32 ] and that is consistent with our findings.…”

Section: Discussionmentioning

confidence: 99%

Overall and sex-specific risk factors for subjective cognitive decline: findings from the 2015–2018 Behavioral Risk Factor Surveillance System Survey

et al. 2022

View full text Add to dashboard Cite

Background Prior research indicates that at least 35% of Alzheimer’s disease and related dementia risk may be amenable to prevention. Subjective cognitive decline is often the first indication of preclinical dementia, with the risk of subsequent Alzheimer’s disease in such individuals being greater in women than men. We wished to understand how modifiable factors are associated with subjective cognitive decline, and whether differences exist by sex. Methods Data were collected from men and women (45 years and older) who completed the U.S. Behavioral Risk Factor Surveillance System Cognitive Decline Module (2015–2018), n = 216,838. We calculated population-attributable fractions for subjective cognitive decline, stratified by sex, of the following factors: limited education, deafness, social isolation, depression, smoking, physical inactivity, obesity, hypertension, and diabetes. Our models were adjusted for age, race, income, employment, marital and Veteran status, and accounted for communality among risk factors. Results The final study sample included more women (53.7%) than men, but both had a similar prevalence of subjective cognitive decline (10.6% of women versus 11.2% of men). Women and men had nearly equivalent overall population-attributable fractions to explain subjective cognitive decline (39.7% for women versus 41.3% for men). The top three contributing risk factors were social isolation, depression, and hypertension, which explained three-quarters of the overall population-attributable fraction. Conclusions While we did not identify any differences in modifiable factors between men and women contributing to subjective cognitive decline, other factors including reproductive or endocrinological health history or biological factors that interact with sex to modify risk warrant further research.

show abstract

“…В зарубежной литературе часто встречается описание когнитивной дисфункции в период менопаузального перехода образным выражением «тумана в голове» (brain fog) [ 25 ]. Выявлена прямая зависимость между частотой жалоб на ухудшение когнитивной функции (ухудшение результатов тестов на внимание, словесную-вербальную, оперативную-краткосрочную память) и длительностью менопаузы [ 26 ]. Отмечается влияние менопаузального статуса на развитие таких симптомов, как беспричинная тревога, депрессивное настроение, беспокойство, нарушения памяти и дисфункция сна [ 27 ][ 28 ].…”

Section: перименопауза и когнитивunclassified

Cognitive and psychoemotional changes in menopausal transition: The possibility of medical correction

Gasparyan¹,

Chotchaeva²,

Karpov³

2023

Probl Endokrinol (Mosk)

View full text Add to dashboard Cite

The increasing of older age group in the population determines studying of age related diseases and emergence of new investigations in this area. In Female body, entering the menopausal transition is the start of «aging» of reproductive function and linked with decreasing of sex hormons levels. A direct connection between changes of estrogen, progesterone, androgen ratios and cognitive function of women was revealed. The anatomical localization of sex hormone receptors, the mechanisms of interaction of hormones with these receptors determine the ways of implementing biological effects of steroids on the CNS. Modern theories of «healthy nerve cells» and «eu-estrogenemia» explains the role of additional criteria, such as the absence of neurological diseases history and the duration of hypoestrogenia, to the outcome of menopausal hormone therapy. Additional factors that can affect to MHT action include: the composition of hormone therapy, administration methods, regimens (cyclic, continuous), duration of treatment, history of endocrine diseases, diabetes mellitus, gynecological history (parity, menarche age, COC use), heredity. The sections present the effect of menopausal transition on the development of depression, mood changes, sleep disturbances and mental disabilities. The explanation of negative effects of menopausal hormone therapy to cognitive health is also described by modern point of view. The ambivalent opinions of researchers, the potential of new reading of the results of earlier studies, confirms the necessity of continuing study of this topic.

show abstract

Menopause and cognitive complaints: are ovarian hormones linked with subjective cognitive decline?

Cited by 24 publications

References 52 publications

Estrogen receptors and the aging brain

Estrogen receptors and the aging brain

Overall and sex-specific risk factors for subjective cognitive decline: findings from the 2015–2018 Behavioral Risk Factor Surveillance System Survey

Cognitive and psychoemotional changes in menopausal transition: The possibility of medical correction

Contact Info

Product

Resources

About