Menopausal symptoms in mid-life women in Southern China

Yang, Dongzi; Haines, Christopher J.; Pan, Peng; Zhang, Qingxue; Sun, Yanmei; Hong, Sihui; Tian, Feng-lian; Bai, Baomin; Xueming, Peng; Chen, Weihong; Yang, Xiaohui; Chen, Yuechang; Feng, Hong; Zhao, Shuhua; Lei, Huizhong; Jiang, Zhou-mei; Ma, Xiaohui; Liao, Weiqiong

doi:10.1080/13697130802239075

Cited by 79 publications

(61 citation statements)

References 18 publications

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“…Continuous variables were presented by median with the interquartile range (IQR: range from the 25 th to 75 th percentile) due to their non-normal distributions. To avoid the confounding influence from age in the gender comparisons, data were stratified by the mean age of menopause of Chinese females (49 years) as previously reported by Yang, et al [26]. For continuous data, differences between females and males were compared using the nonparametric Mann-Whitney test.…”

Section: Discussionmentioning

confidence: 99%

Female sex hormones are associated with the reduction of serum sodium and hypertension complications in patients with aldosterone-producing adenoma

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Female sex hormones are associated with the reduction of serum sodium and hypertension complications in patients with aldosterone-producing adenoma

et al. 2013

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“…The dose of estrogen has been considered to be most directly related to the adverse effects of COC use, however, the dose was not involved in our analysis. In addition, exogenous estrogen from hormone replacement therapy (HRT) of postmenopausal aged women who are at high risk of stroke was not investigated, although HRT was reported to increase risk of ischemic stroke but not hemorrhagic stroke (Wassertheil-Smoller et al 2003), and the extremely low usage in China compared with that in the developed countries (Yang et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case–control study in China

Chün

Liu

et al. 2012

Hum Genet

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Combined oral contraceptives (COC) use is a unique risk factor for stroke in women, and may modify the associations between genetic polymorphisms and stroke. To investigate whether the genetic variants identified in a recent genome-wide association study (GWAS) could be replicated in Chinese women, as well as, whether related risk was different in COC users, 451 stroke cases and 831 age- and region-matched controls were recruited from our cohort. Genotyping of 3 SNPs (rs700651, rs10958409, and rs1333040) was performed by the polymerase chain reaction assay with TaqMan probes. The history of contraceptive use and relevant information were obtained from a face-to-face interview. Odds ratios (OR) with 95 % confidence interval (CI) were estimated under conditional logistic regression model after adjustment for cardiovascular covariates. Our study replicated the associations of rs10958409 and rs1333040, with the risk of stroke, especially hemorrhagic subtype, but failed to confirm association of rs700651. COC use was associated with a 1.56-fold (OR 1.56, 95 % CI 1.21-2.01) increased risk of stroke. COC users with rs10958409 GA/AA or rs1333040 CT/TT genotypes had an increased risk of overall stroke by 1.59-fold (OR 2.59, 95 % CI 1.59-4.19) and 3.24-fold (OR 4.24, 95 % CI 1.71-10.49), respectively, compared with the non-users with wild-type genotypes. Moreover, the risk of hemorrhagic stroke increased by 4.81- and 15.06-fold when risk allele carriers of rs10958409 or rs1333040 who took COC. Our results confirmed the associations of two GWAS SNPs, also suggested combination effects of these genetic variants and COC use on stroke risk.

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“…The average menopause age in Chinese women has been confirmed to be around 49 years (16,17). A systematic review by de Rooij et al suggested that at younger ages the aneurysmal SAH incidence is higher in men, whereas, after the age of 55, the incidence is higher in women.…”

Section: Introductionmentioning

confidence: 99%

“…Experimental study also demonstrated a sex-specific hormonal factor may play a role in the pathogenesis of aneurysm formation and rupture (14,15). Because it is a relatively common cause of stroke in women under age 65 and because of its high morbidity and mortality, the excess of aneurysmal SAH in women remains a pressing question in stroke research.The average menopause age in Chinese women has been confirmed to be around 49 years (16,17). A systematic review by de Rooij et al suggested that at younger ages the aneurysmal SAH incidence is higher in men, whereas, after the age of 55, the incidence is higher in women.…”

mentioning

confidence: 99%

A higher aneurysmal subarachnoid hemorrhage incidence in women prior to menopause: a retrospective analysis of 4,895 cases from eight hospitals in China

Wáng

Zhang

et al. 2016

Quant. Imaging Med. Surg.

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Background: Subarachnoid hemorrhage (SAH) from a ruptured cerebral aneurysm is a devastating disease.Despite the risk factors, including hypertension, cigarette smoking and alcohol use, are more common in men, aneurysmal SAH belongs to a few diseases which the incidence is higher in women than in men. Sex hormones, especially estrogen, might be protective against this condition. Hormone replacement therapy (HRT) seems to be associated with a reduced risk for aneurysmal SAH. This study aims to know the prevalence of aneurysmal SAH of men and women at different ages. Methods:The age and gender information of 4,895 case of aneurysmal SAH (3,016 females, 1,879 males) were collected retrospectively from eight institutions in mainland China. The prevalence of aneurysmal SAH of men and women at different ages was analyzed.Results: The data showed women had a higher incidence of aneurysmal SAH than men starting at late thirties, and men might have a higher incidence of aneurysmal SAH than women only before 37-year-old.Conclusions: Menopause may not be the only dominant factor causing higher incidence of aneurysmal SAH in women than in men. Quant Imaging Med Surg 2016;6(2):151-156 qims.amegroups.com the short-term and long-term risks of aneurysmal rupture with the risk associated with the intervention, whether it would be surgical clipping or endovascular management. Controversy remains regarding optimum management, and thorough assessments of the risks and benefits of contemporary management options, specific to aneurysm size, location, and many other aneurysm and patient factors, are needed. Endovascular management options continue to improve as micro-catheter technology advances and newer devices and embolic materials are developed. The most commonly used endovascular option is the Guglielmi detachable coil system. This system allows delivery of soft platinum coils into intracranial aneurysms. Overall, clinical trial data showed better recovery data with patients treated endovascularly than treated surgically (3). Findings from several studies also suggested that cerebral aneurysm rupture risk is reduced in patients taking aspirin (4). Recent data support long-term serial screening in individuals with a family history of aneurysmal SAH (5).Despite the risk factors, including hypertension, cigarette smoking and alcohol use, are more common in men, aneurysmal SAH belongs to a few diseases which the incidence is higher in women than in men (1-3,6,7). Women have a significantly higher risk for de novo cerebral aneurysm formation than men in a long-term follow-up study, being female is a significant independent risk factor for aneurysm growth; and women are more likely than men to have multiple cerebral aneurysms (7-9). It has been noted that the incidence was higher in younger men, whereas after the age of 55, the incidence was higher in women (2). Furthermore, earlier age at menopause may be associated with a greater risk of cerebral aneurysm (10). Therefore, a sex-specific hormonal factor may play a role in the pathogen...

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Menopausal symptoms in mid-life women in Southern China

Abstract: The prevalence of menopausal symptoms in southern Chinese women is low, and this is accompanied by low usage of hormone replacement therapy.

Cited by 79 publications

References 18 publications

Female sex hormones are associated with the reduction of serum sodium and hypertension complications in patients with aldosterone-producing adenoma

Female sex hormones are associated with the reduction of serum sodium and hypertension complications in patients with aldosterone-producing adenoma

Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case–control study in China

A higher aneurysmal subarachnoid hemorrhage incidence in women prior to menopause: a retrospective analysis of 4,895 cases from eight hospitals in China

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