Menopausal symptoms and associated factors in HIV-positive women

Lui-Filho, Jeffrey Frederico; Valadares, Ana Lúcia Ribeiro; Gomes, Debora de C.; Amaral, Eliana; Pinto‐Neto, Aarão Mendes; Costa-Paiva, Lúcia

doi:10.1016/j.maturitas.2013.07.012

Cited by 24 publications

(32 citation statements)

References 26 publications

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“…Boonyanurak at al., (12) in their study of HIV-positive women in Thailand, found that night sweats and loss of sexual desire were more prevalent in postmenopausal WLWHIV compared to those who were premenopausal. One study has found no association between HIV-status and menopausal symptoms (including vasomotor, genitourinary and psychological symptoms), (25) whereas increased symptoms have been reported by other authors. (15,(26)(27)(28)(29) Vasomotor symptoms are relatively well-investigated in WLWHIV.…”

Section: Symptomatology and Management Of The Menopause Transition Inmentioning

confidence: 88%

“…(15,(26)(27)(28)(29) Vasomotor symptoms are relatively well-investigated in WLWHIV. The reported prevalence of vasomotor symptoms in HIV-positive women ranges from 64-87%, (14,15,25,(28)(29)(30) which is not dissimilar to the rate reported in women without HIV. (4) Higher CD4 counts appear to be associated with increased symptoms in HIV-positive women.…”

Section: Symptomatology and Management Of The Menopause Transition Inmentioning

confidence: 96%

“…(26,31) Another analysis of WIHS data also found that vasomotor symptoms were associated with decreased scores in cognitive measures, however there was no difference by HIV serostatus. (32) The prevalence of psychological symptoms (including depression and anxiety) in WLWHIV during the menopause transition ranges from 38% to over 95%, (15,25,26,29,31) with the variation likely to be largely due to the use of different outcome measures and differences in populations. Although psychological symptoms such as depression are reported more frequently by women in the context of HIV regardless of menopausal status, both Ferreira at al.…”

Section: Symptomatology and Management Of The Menopause Transition Inmentioning

confidence: 99%

“…(31) Genitourinary symptoms are common both peri-and postmenopausally. It is estimated that the prevalence these symptoms in WLWHIV is 48-73%, (14,15,25,29) with Ferreira et al (15) reporting an association with HIV-infection. Decreased sexual function has been reported in WLWHIV at all ages, and has been shown to decline postmenopausally in women regardless of HIV serostatus.…”

Section: Symptomatology and Management Of The Menopause Transition Inmentioning

confidence: 99%

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The impact of the menopause transition on the health and wellbeing of women living with HIV: A narrative review

2016

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Improvements in survival due to advances in antiretroviral therapy (ART) have led to a shift in the age distribution of those receiving HIV care, with increasing numbers of women living with HIV (WLWHIV) reaching menopausal age. We present a narrative literature review of 26 studies exploring the menopause transition in WLWHIV, focusing on: (1) natural history (2) symptomatology and management, and (3) immunologic and virologic effects.Data are conflicting on the association between HIV and earlier age at menopause, and the role of HIV-specific factors such as HIV viral load and CD4 count. There are some data to suggest that WLWHIV experience more vasomotor and psychological symptoms during the menopause than HIV-negative women, and that uptake of hormone replacement therapy by WLWHIV is comparatively low. There is no evidence that menopause affects either CD4 count or response to ART, although there may be increased immune activation in older WLWHIV.We conclude that menopause in WLWHIV is a neglected area of study. Specific information gaps include qualitative studies on experiences of reproductive ageing; data on the impact of the menopause on women's quality of life and ability to adhere to health-sustaining behaviors; as well as studies investigating the safety and efficacy of pharmacological and psychosocial interventions. There is likely to be a burden of unmet health need among this growing population, and better data are required to inform optimal provision of care, supporting WLWHIV to maintain their health and wellbeing into their post-reproductive years.Word count: 2065

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Section: Symptomatology and Management Of The Menopause Transition Inmentioning

confidence: 88%

Section: Symptomatology and Management Of The Menopause Transition Inmentioning

confidence: 96%

Section: Symptomatology and Management Of The Menopause Transition Inmentioning

confidence: 99%

Section: Symptomatology and Management Of The Menopause Transition Inmentioning

confidence: 99%

See 2 more Smart Citations

The impact of the menopause transition on the health and wellbeing of women living with HIV: A narrative review

2016

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“…In these women, low BMD or osteoporosis was defined as a Zscore below −2.0 SD at the lumbar spine, femoral neck, or total hip. For postmenopausal women (no menses for 1 year), T-score was used and low BMD or osteoporosis was defined as a T-score below −2.5 SD at the lumbar spine, femoral neck, or total hip [17][18][19]. The independent variables were HIV group (positive/negative), age (years), skin color (white or non-white), physical activity in the last month (none or up to two times per week/≥3 times per week), smoking (yes/no or in the past), alcohol consumption (yes/no or never drank), amount of alcohol consumption (more than one dose per day/one dose or less per day or unknown), number of pregnancies (up to 2/≥3), menopausal status (premenopause/perimenopause/postmenopause), use of hormone replacement therapy in the last month (yes/no), history of fractures (yes/ no), history of spine, hip, and/or forearm fracture after the age of 40 (yes/no), use of antiretroviral therapy (yes/no), hypothyroidism (yes/no), BMI (<25/≥25.0 kg/m 2 ), FSH (<40/ ≥40 mIU/ml); TSH (normal/hypothyroidism or hyperthyroidism), and free T4 (normal/abnormal).…”

Section: Methodsmentioning

confidence: 99%

Association between HIV infection and bone mineral density in climacteric women

et al. 2015

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The mean age was 47.7 years in HIV-seropositive women, and 75 % had nadir CD4 above 200, and 77.8 % had viral load below the detection limit. The mean age in the HIV-seronegative women was 49.8 years. The prevalence of low spinal BMD was 14.6 % in the HIV-seropositive and 4.6 % in the HIV-seronegative women (p < 0.01). The prevalence of low BMD at the femoral neck was 5.6 % in HIV-seropositive and 3.3 % in the HIV-seronegative women (p = 0.38). Multiple analyses showed that the factors associated with lower BMD at the spine were being postmenopausal and being HIV-seropositive. Being overweight was associated with a higher BMD. At the femoral neck, factors associated with lower BMD were being postmenopausal and being white. Being overweight and having a greater number of pregnancies were associated with higher BMD CONCLUSIONS: HIV-seropositive women on long-term antiretroviral treatment and in good immunological conditions exhibited low BMD in the spine (L1-L4). However, BMD in the femoral neck was similar to non-infected women.

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The Prevalence and Patterns of Menopausal Symptoms in Women Living with HIV

et al. 2022

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Increasing numbers of women with HIV are experiencing menopause. We use data from a large, representative sample of women with HIV to describe the prevalence and clustering of menopausal symptoms amongst pre-, peri- and post-menopausal women using hierarchical agglomerative cluster analysis. Of the 709 women included, 21.6%, 44.9% and 33.6% were pre-, peri- and post-menopausal, respectively. Joint pain (66.4%) was the most commonly reported symptom, followed by hot flashes (63.0%), exhaustion (61.6%) and sleep problems (61.4%). All symptoms were reported more commonly by peri- and post-menopausal women compared to pre-menopausal women. Psychological symptoms and sleep problems clustered together at all menopausal stages. Somatic and urogenital symptom clusters emerged more distinctly at peri- and post-menopause. We recommend regular and proactive assessment of menopausal symptoms in midlife women with HIV, with an awareness of how particular patterns of symptoms may evolve over the menopausal transition.

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Menopausal symptoms and associated factors in HIV-positive women

Cited by 24 publications

References 26 publications

The impact of the menopause transition on the health and wellbeing of women living with HIV: A narrative review

The impact of the menopause transition on the health and wellbeing of women living with HIV: A narrative review

Association between HIV infection and bone mineral density in climacteric women

The Prevalence and Patterns of Menopausal Symptoms in Women Living with HIV

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