Menopausal Hormone Therapy and Vascular Events: What is their Relationship?

Kuznetsov, M R; Папышева, О. В.

doi:10.31550/1727-2378-2018-154-10-51-55

Cited by 2 publications

(1 citation statement)

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“…Отмечено, что женщинам с преждевременной или ранней менопаузой (до 42 лет) (спонтанной или хирургической) свойственен удвоенный риск возникновения тромботических осложнений -ишемического инсульта, инфаркта миокарда, в отличие от женщин с более поздней менопаузой [14]. В опубликованном в 2016 году метаанализе 32 исследований, обобщившем 310 329 наблюдений, взаимосвязь ранней менопаузы с развитием ишемической болезни сердца (ИБС) и высокой смертностью на ее фоне нашла убедительное подтверждение [15] Сердечно-сосудистые заболевания / Cardiovascular medicine сивные разработки новых схем и методик приема ГП. Со времени начала их внедрения в клиническую практику прошло почти полвека.…”

Section: Thromboembolic Complications Of Hormonal Therapy In Women Punclassified

Thromboembolic complications of hormonal therapy in women. Position of cardiologist

Gorlova

Омельченко

Соколова

et al. 2020

Transl. med. (Print)

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Thromboembolic complications is a frequent cause of acute cardiovascular events, disability and mortality. Among the factors that increase their risk in the female population using of medications, containing sex hormones is of high significance. In oral contraceptives the main — contraceptive activity belongs to gestagen, while estrogen performs an auxiliary function of menstrual cycle control. In medications used for therapy during menopause the main active substance is estrogen. Progestin provides prevention of endometrial hyperplasia. Despite the intensive search for optimal effective and safe schemes of combined hormonal drugs, the risk of thrombotic complications in patients using them both for therapeutic purposes and as contraception remains high. The article provides clinical observations illustrating the administration of hormonal therapy to women is reasonable to be discussed and agreed with cardiologists and/or general practitioners, and the patients would be informed about possible cardiovascular complications of such therapy for an adequate selfcontrol.

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Section: Thromboembolic Complications Of Hormonal Therapy In Women Punclassified