Menopausal Hormone Therapy

Stuenkel, Cynthia A.

doi:10.1016/j.ecl.2015.05.006

Cited by 13 publications

(1 citation statement)

References 75 publications

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“…Hormone replacement therapy in postmenopausal women is associated with severe side effects, such as an increased risk of coronary heart disease, breast cancer, stroke, and venous thromboembolism ( 8 , 9 ). Nevertheless, it is still the most effective treatment for postmenopausal symptoms and for carefully selected women, benefits could exceed risks ( 10 , 11 ). Selective estrogen receptor modulators have beneficial effects on the musculoskeletal system like estrogen, they have fewer adverse events on breasts and the uterus.…”

Section: Introductionmentioning

confidence: 99%

Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model

et al. 2020

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New potential selective estrogen receptor modulators in traditional Chinese medicine for treating menopausal syndrome

Song,

Shen,

Contreras

et al. 2024

Phytotherapy Research

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Women go through several predictable conditions and symptoms during menopause that are caused by age, changes in sex hormone levels, and other factors. Conventional menopause hormone therapy has raised serious concerns about the increased risks of cancers, blood clots, depression, etc. Selective estrogen receptor modulators (SERMs) that can be both agonists and antagonists of estrogen receptors in a tissue‐specific manner are being developed to reduce the health concerns associated with menopause hormone therapy. Here, we have searched the Chinese national traditional Chinese medicine (TCM) patent database to identify potential SERM‐like compounds with reduced health risks. TCM has been widely used for treating complex symptoms associated with menopause syndrome and thus can be a particularly rich source for pharmaceutical alternatives with SERM properties. After extensive literature review and molecular simulation, we conclude that protopanaxatriol, paeoniflorin, astragalin, catalpol, and hyperoside among others may be particularly promising as SERM‐like compounds in treating the menopausal syndrome. Compounds in TCM hold promise in yielding comparable outcomes to hormone therapy but with reduced associated risks, thus presenting promising avenues for their clinical applications.

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